Compositions and methods for prevention and treatment of immune deficiency and inflammation

Abstract

Disclosed herein are compositions and methods for the prevention and treatment of immune deficiency and inflammation using cyclic histidyl-proline plus zinc (Cyclo-Z). Disclosed herein are compositions that can be used to treat immune disorders and inflammation.

What is claimed is: 
     
         1 . A pharmaceutical composition to treat immune disorder and inflammation in mammals, the composition comprising:
 zinc salt comprising zinc cation and anion;   purified cyclic histidyl-proline (CHP); and   a pharmaceutically-acceptable excipient.   
     
     
         2 . The pharmaceutical composition of  claim 1 , wherein the zinc salt comprises zinc chloride. 
     
     
         3 . The pharmaceutical composition of  claim 1 , wherein the zinc salt comprises zinc oxide. 
     
     
         4 . The pharmaceutical composition of  claim 1 , wherein the zinc salt comprises zinc carbonate. 
     
     
         5 . A pharmaceutical composition comprising a capsule that comprises:
 a zinc chelating agent;   cyclic histidyl-proline (CHP); and   one or more excipients.   
     
     
         6 . The pharmaceutical composition of  claim 5 , wherein the capsule is a hard gel capsule. 
     
     
         7 . The pharmaceutical composition of  claim 5 , wherein the capsule is a soft gel capsule. 
     
     
         8 . The pharmaceutical composition of  claim 5 , wherein each capsule comprises 10-150 mg of zinc. 
     
     
         9 . The pharmaceutical composition of  claim 8 , wherein each capsules comprises 10-100 mg of zinc, depending on an age, gender, and physiological condition of a patient. 
     
     
         10 . The pharmaceutical composition of  claim 5 , wherein each capsule comprises 3-50 mg of CHP. 
     
     
         11 . The pharmaceutical composition of  claim 10 , wherein each capsule comprises 3-30 mg of CHP, depending on an age, gender, and physiological condition of a patient. 
     
     
         12 . A method of treating a disease of a patient, the method comprising administering cyclic histidyl-proline plus zinc (Cyclo-Z) to the patient. 
     
     
         13 . The method of  claim 12 , wherein the Cyclo-Z is orally administered to the patient. 
     
     
         14 . The method of  claim 13 , wherein the Cyclo-Z is orally administered to the patient via a capsule. 
     
     
         15 . The method of  claim 14 , wherein the capsule is taken 1-4 times per day. 
     
     
         16 . The method of  claim 15 , wherein the capsule is taken once between waking up and breakfast, once between breakfast and lunch, once between lunch and dinner, and once between dinner and bedtime. 
     
     
         17 . The method of  claim 14 , wherein the capsule is taken 2 times per day. 
     
     
         18 . The method of  claim 17 , wherein the capsule is taken once between waking up and breakfast and once between breakfast and dinner or bedtime. 
     
     
         19 . The method of  claim 14 , wherein the capsule is taken once per day at bedtime. 
     
     
         20 . The method of  claim 12 , wherein the Cyclo-Z comprises 5 mg/L of cyclic histidyl-proline and 20 mg/L of zinc. 
     
     
         21 . The method of  claim 12 , wherein the disease is an immune-disorder or inflammatory disease. 
     
     
         22 . The method of  claim 21 , wherein the disease is a cold. 
     
     
         23 . The method of  claim 21 , wherein the disease is influenza. 
     
     
         24 . The method of  claim 21 , wherein the disease is a bacterial infection. 
     
     
         25 . The method of  claim 21 , wherein the disease is an allergy. 
     
     
         26 . The method of  claim 21 , wherein the disease is type-one diabetes. 
     
     
         27 . The method of  claim 21 , wherein the disease is type-two diabetes. 
     
     
         28 . The method of  claim 12 , wherein the Cyclo-Z is administered to the patient 1-4 times per day.