Composition containing chlorine dioxide and methods for using same

Abstract

The present invention relates to a composition comprising chlorine dioxide useful in the treatment of active infections of the eye, as well as prophylaxis and treatment of such infections. The invention also relates to uses of compositions including effective amounts of chlorine dioxide in the eye to obtain benefit without detrimentally affecting the eye.

1 . An ophthalmic composition comprising an effective amount of chlorine dioxide, about 0.01% (w/w) to about 2% (w/w) dextrin or cyclodextrin, and an aqueous medium. 
     
     
         2 . The composition of  claim 1 , wherein the chlorine dioxide is chlorine dioxide containing complexes selected from the group consisting of complexes of chlorine dioxide with carbonate, complexes of chlorine dioxide with bicarbonate, stabilized oxychloro complex (SOC), and combinations thereof. 
     
     
         3 . The composition of  claim 1 , wherein the chlorine dioxide comprises about 0.005% (w/w) to about 10% (w/w) of the total composition. 
     
     
         4 . The composition of  claim 1 , further comprising nanoparticles or microparticles selected from the group consisting of hybrid polyamidoamine (PAMAM) dendrimer hydrogel/poly (lactic-co-glycolic acid) (PLGA) nanoparticles or microparticles (HDNP); chitosan (CS) nanoparticles or microparticles; thiolated chitosan nanoparticles or microparticles; calcium phosphate (CaP) nanoparticles or microparticles; poly (lactic-co-glycolic acid) copolymer (PLGA) nanoparticles or microparticles; poly (ethyleneglycol)-block-poly(caprolactone) nanoparticles or microparticles; core/shell nanoparticles or microparticles composed of a lecithin liposome core; PEG-block-PPG diacrylate copolymer (DA-PF 127) nanoparticles and microparticles; inorganically-coated retinoic acid (atRA) nanoparticles or microparticles; poly (lactic acid) (PLA) homopolymers and PEG-block-PLA copolymer nanoparticles or microparticles; PEG-block-PPG copolymer nanoparticles and microparticles; PEGylated liposome-protamine-hyaluronic acid nanoparticles or microparticles; polylactic acid/polylactic acid-polyethylene oxide (PLA/PLA-PEO) nanoparticles or microparticles; and combinations thereof. 
     
     
         5 . The composition of  claim 4 , wherein the composition comprises nanoparticles having a diameter of from about 2 nanometers to about 200 nanometers. 
     
     
         6 . The composition of  claim 1 , wherein the composition comprises nanoparticles or microparticles selected from the group consisting of mucus penetrating particles. 
     
     
         7 . The composition of  claim 7 , wherein the mucus penetrating particles include a core particle comprising at least about 80 wt. % chlorine dioxide or chlorine dioxide precursor and less than about 20 wt. % polymer, and a surface-altering agent coating surrounding the core particle. 
     
     
         8 . The composition of  claim 8 , wherein the surface-altering agent comprises a triblock copolymer having a hydrophilic block-hydrophobic block-hydrophilic block configuration in which each hydrophobic block have a molecular weight of at least about 2 kDa. 
     
     
         9 . The composition of  claim 8 , wherein the surface-altering agent has a density of at least about 0.001 molecules per nanometer squared and the coated particles may have a relative velocity of greater than 0.5 in mucus. 
     
     
         10 . The composition of  claim 1 , wherein the composition comprises liposomes. 
     
     
         11 . The composition of  claim 11 , wherein the liposomes are selected from the group consisting of phosphatidylcholine (PC) and cholesterol, lipid-conjugated hydrophilic polymers, chitosan, and combinations thereof. 
     
     
         12 . The composition of  claim 11 , wherein the liposomes are coated in chitosan. 
     
     
         13 . The composition of  claim 11 , wherein the liposomes have a mean particle diameter of about 1 nanometers to about 50 nanometers. 
     
     
         14 . The composition of  claim 1 , further comprising ophthalmic astringents, ophthalmic demulcent, ophthalmic emollients, ophthalmic hypertonicity, ophthalmic vasoconstrictor, oxygen-releasing components, viscosity agents, additional active agents, anti-inflammatories, steroids, anesthetic, antimicrobial agents, vasoconstrictor, or combinations thereof. 
     
     
         15 . The composition of  claim 1 , further comprising methylcellulose, carboxymethylcellulose, hydroxyethyl cellulose, hydroxypropyl methyl cellulose, and combinations thereof. 
     
     
         16 . The composition of  claim 1 , wherein the methylcellulose, carboxymethylcellulose, hydroxyethyl cellulose, hydroxypropyl methylcellulose, and combinations thereof has a concentration of about 0.05% (w/w) to about 5% (w/w). 
     
     
         17 . The composition of  claim 1 , wherein the composition is in a form for topical delivery selected from the group consisting of cream, lotion, ointment, gel, liquid, and spray. 
     
     
         18 . A method for treating viral or bacterial infections of the eye comprising contacting an eye or a patient in need of treatment with an effective amount of a composition comprising chlorine dioxide, about 0.01% (w/w) to about 2% (w/w) dextrin or cyclodextrin, and an aqueous medium. 
     
     
         19 . The method of  claim 16 , wherein contacting comprises periodic or repeated applications of the composition to the eye. 
     
     
         20 . The method of  claim 16 , wherein the patient is undergoing or has undergone an ocular surgical procedure. 
     
     
         21 . The method of  claim 16 , wherein the chlorine dioxide is encapsulated within nanoparticles or microparticles, ionically associated with nanoparticle or microparticles, or combinations thereof. 
     
     
         22 . An ophthalmic composition comprising an effective amount of chlorine dioxide, polyacrylic acid, and an aqueous medium. 
     
     
         23 . The composition of  claim 20 , wherein the chlorine dioxide is chlorine dioxide containing complexes selected from the group consisting of complexes of chlorine dioxide with carbonate, complexes of chlorine dioxide with bicarbonate, stabilized oxychloro complex (SOC), and combinations thereof. 
     
     
         24 . The composition of  claim 20 , wherein the chlorine dioxide comprises about 0.005% (w/w) to about 10% (w/w) of the total composition.