J-series prostaglandin-ethanolamides as novel therapeutics for skin and/or oral disorders

Abstract

Provided is a method of preventing and/or treating a skin disorder and/or an oral disorder including administering to a subject in need thereof an effective amount of a compound of formula (I): or a prodrug or derivative thereof, and salts thereof.

That which is claimed is: 
     
         1 . A method of treating human papillomavirus (HPV) comprising administering to a subject in need thereof an effective amount of a compound of formula (I) or formula (II): 
       
         
           
           
               
               
           
         
       
       a salt thereof, or any combination thereof. 
     
     
         2 . The method of  claim 1 , wherein the administration is topical administration. 
     
     
         3 . The method of  claim 1 , wherein the administration is by injection and/or infusion. 
     
     
         4 . The method of  claim 1 , wherein the HPV is effected by endoplasmic reticulum (ER) stress and/or exhibits increased ER stress. 
     
     
         5 . The method of  claim 4 , wherein the HPV exhibits increased ER stress during the growth cycle of skin and/or oral cells. 
     
     
         6 . The method of  claim 1 , wherein the method induces cell death in an ER-stress dependent mechanism. 
     
     
         7 . The method of  claim 1 , wherein a pharmaceutical composition is administered to the subject, the pharmaceutical composition comprising the compound of formula (I) and a pharmaceutically acceptable carrier. 
     
     
         8 . The method of  claim 1 , wherein the compound is the compound of formula (I) or a salt thereof. 
     
     
         9 . The method of  claim 1 , wherein the compound is the compound of formula (II) or a salt thereof. 
     
     
         10 . A kit comprising:
 a first container comprising a first pharmaceutical composition, wherein the first pharmaceutical composition comprises a first pharmaceutical carrier and a compound of formula (I):   
       
         
           
           
               
               
           
         
       
       or a prodrug or derivative thereof, and salts thereof. 
     
     
         11 . The kit of  claim 10 , further comprising a second pharmaceutical composition, wherein the second pharmaceutical composition comprises a second pharmaceutical carrier and a second therapeutic. 
     
     
         12 . The kit of  claim 10 , wherein the first pharmaceutical composition and the second pharmaceutical composition are separately stored in the kit. 
     
     
         13 . The kit of  claim 10 , further comprising a second container comprising the second pharmaceutical composition. 
     
     
         14 . The kit of  claim 10 , wherein the first and/or second container deliver the first and/or second pharmaceutical composition. 
     
     
         15 . The kit of  claim 10 , wherein the second therapeutic is a therapeutic for human papillomavirus (HPV). 
     
     
         16 . The kit of  claim 10 , wherein the second therapeutic is an agent used in antineoplastic chemotherapy or radiotherapy.