Compositions

Abstract

The present invention relates to the use of a fruit extract and optionally other specific nutrients for preventing, reducing or minimising exercise-induced systemic inflammation and/or for promoting recovery from intense exercise. The invention also relates to compositions comprising such fruit extracts.

1 - 22 . (canceled) 
     
     
         23 . A composition comprising:
 (a) a water-soluble extract of tomato fruit, wherein the extract:
 consists of components having a molecular weight of less than 1000; and 
 (ii) contains one or more of a nucleoside; a glycosylated phenolic acid or a phenolic ester, or a glycosylated flavonoid; 
   (b) an exogenous source of dietary nitrate or a precursor of endogenous nitric oxide selected from citrulline, glutamine or arginine and wherein the exogenous source comprises a water-based extract of fresh fruit or vegetable tissue, wherein the fruit or vegetable contains levels of nitrate sufficiently high to result in final extract concentrations of 7.5 g/l nitrate or greater; and   (c) folic acid or a metabolite of folic acid selected from 5-methoxytetrahydrofolate or tetrahydrofolate.   
     
     
         24 . The composition according to  claim 23  wherein the source of dietary nitrate (b) is selected from a water-soluble extract from Swiss chard, rocket, spinach, rhubarb, strawberry and lettuce. 
     
     
         25 . The composition according to  claim 23  in the form of a pharmaceutical product, nutraceutical product, drink, food substance or food supplement. 
     
     
         26 . The composition according to  claim 23  formulated as a gel, powder, food bar or dispersable tablet. 
     
     
         27 . A dosage form comprising the composition of  claim 23  comprising between 25 mg and 250 mg of nitrate. 
     
     
         28 . The dosage form according to  claim 27  comprising between 10 mg and 500 mg of folic acid. 
     
     
         29 . A method of treating, reducing, minimising or preventing exercise-induced systemic inflammation in a subject, comprising:
 administering a composition to the subject, wherein the composition comprises:
 (a) a water-soluble extract of tomato fruit, wherein the extract:
 (i) consists of components having a molecular weight of less than 1000; and 
 (ii) contains one or more of a nucleoside; a glycosylated phenolic acid or a phenolic ester, or a glycosylated flavonoid; and 
 
 (b) an exogenous source of dietary nitrate or a precursor of endogenous nitric oxide selected from citrulline, glutamine or arginine and wherein the exogenous source comprises a water-based extract of fresh fruit or vegetable tissue, wherein the fruit or vegetable contains levels of nitrate sufficiently high to result in final extract concentrations of 7.5 g/l nitrate or greater. 
   
     
     
         30 . A method of promoting recovery from exercise in a subject conducted at an intensity corresponding to greater than 60% VO2max, comprising:
 administering a composition to the subject, wherein the composition comprises:
 (a) a water-soluble extract of tomato fruit, wherein the extract:
 (i) consists of components having a molecular weight of less than 1000; and 
 (ii) contains one or more of a nucleoside; a glycosylated phenolic acid or a phenolic ester, or a glycosylated flavonoid; and 
 
 (b) an exogenous source of dietary nitrate or a precursor of endogenous nitric oxide selected from citrulline, glutamine or arginine and wherein the exogenous source comprises a water-based extract of fresh fruit or vegetable tissue, wherein the fruit or vegetable contains levels of nitrate sufficiently high to result in final extract concentrations of 7.5 g/l nitrate or greater.