US2021163449A1PendingUtilityA1
Inhibitors of trpc6
Est. expiryOct 27, 2037(~11.2 yrs left)· nominal 20-yr term from priority
Inventors:Thierry BouyssouDirk GottschlingNiklas HeineLana Louise Smith KeenanMichael Dennis LoweHossein RazaviChristopher Ronald SarkoSimon SurprenantHidenori TakahashiMichael Robert TurnerXinyuan Wu
A61P 25/28A61P 13/12A61P 3/10A61P 11/00A61P 9/00A61K 31/501C07D 213/04C07D 498/08C07D 487/08C07D 401/12C07D 451/02C07D 401/14A61K 31/45A61K 31/496
68
PatentIndex Score
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Claims
Abstract
The invention relates to compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein R 1 to R 7 , A, Y and L are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
Claims
exact text as granted — not AI-modified1 - 12 . (canceled)
13 . A method of treating cancer, wherein the cancer is brain cancer, breast cancer, kidney cancer, cervical cancer, prostate cancer, gastrointestinal cancer, skin cancer, or epithelial cancer,
comprising the step of administering to a patient in need thereof a therapeutically effective amount of a compound selected from the group consisting of:
Cmpd
No.
Structure
Compound Name
1
[4-(6-Amino-4-methoxy-pyridin-3-yl)- piperazin-1-yl]-[5-(4-fluoro-phenoxy)-4- methoxy-pyridin-2-yl]-methanone
2
(6-Amino-4-methyl-3′,4′,5′,6′-tetrahydro- 2′H-[3,4′]-bipyridinyl-1′-yl)-[5-(4-fluoro- phenoxy)-4-methoxy-pyridin-2-yl]- methanone
3
(6-Amino-3′,4′,5′,6′-tetrahydro-2′H- [3,4′]bipyridinyl-1′-yl)-(4-methoxy-5- phenoxy-pyridin-2-yl)-methanone
4
(6-Amino-4-methoxy-3′,4′,5′,6′-tetrahydro- 2′H-[3,4′]bipyridinyl-1′-yl)-[5-(4-fluoro- phenoxy)-4-methoxy-pyridin-2-yl]- methanone
5
[4-(6-Amino-4-methoxy-pyridin-3-yl)- piperazin-1-yl]-(4-methoxy-5-phenoxy- pyridin-2-yl)-methanone
6
[4-(6-Amino-pyridazin-3-yl)-piperidin-1-yl]- [5-(4-isopropoxy-phenoxy)-4-methoxy- pyridin-2-yl]-methanone
7
[(R)-4-(6-Amino-4-methyl-pyridin-3-yl)-2- hydroxymethyl-piperazin-1-yl]-[5-(4- fluoro-phenoxy)-4-methoxy-pyridin-2-yl]- methanone
8
[7-(6-Amino-4-methoxy-pyridin-3-yl)-4,7- diaza-spiro[2.5]oct-4-yl]-(4-methoxy-5- phenoxy-pyridin-2-yl)-methanone
9
[7-(6-Amino-4-methoxy-pyridin-3-yl)-4,7- diaza-spiro[2.5]oct-4-yl]-[5-(4-fluoro- phenoxy)-4-methoxy-pyridin-2-yl]- methanone
10
(6-Amino-4-methyl-3′,4′,5′,6′-tetrahydro- 2′H-[3,4′]bipyridinyl-1′-yl)-(4-methoxy-5- phenoxy-pyridin-2-yl)-methanone
11
[4-(6-Amino-5-methoxy-pyridazin-3-yl)- piperidin-1-yl]-[5-(4-fluoro-phenoxy)-4- methoxy-pyridin-2-yl]-methanone
12
[4-(6-Amino-pyridin-3-yl)-piperazin-1-yl]- [4-methoxy-5-(4-methoxy-phenoxy)- pyridin-2-yl]-methanone
13
[4-(6-Amino-pyridin-3-yl)-piperazin-1-yl]- [5-(4-fluoro-phenoxy)-4-methoxy-pyridin- 2-yl]-methanone
14
(6-Amino-3′,4′,5′,6′-tetrahydro-2′H- [3,4′]bipyridinyl-1′-yl)-[5-(4-fluoro- phenoxy)-4-methoxy-pyridin-2-yl]- methanone
15
[4-(6-Amino-pyridin-3-yl)-piperazin-1-yl]- (4-methoxy-5-phenoxy-pyridin-2-yl)- methanone
16
[4-(6-Amino-pyridazin-3-yl)-piperidin-1-yl]- (4-methoxy-5-phenoxy-pyridin-2-yl)- methanone
17
[4-(6-Amino-pyridazin-3-yl)-piperidin-l-yl]- [5-(4-fluoro-phenoxy)-4-methoxy-pyridin- 2-yl]-methanone
18
[(R)-4-(6-Amino-4-methyl-pyridin-3-yl)-2- hydroxymethyl-piperazin-1-yl]-(4- methoxy-5-phenoxy-pyridin-2-yl)- methanone
19
(6-Amino-4-methoxy-3′,4′,5′,6′-tetrahydro- 2′H-[3,4′]bipyridinyl-1′-yl)-[5-(2-fluoro- benzyloxy)-4-methoxy-pyridin-2-yl]- methanone
20
[(R)-4-(6-Amino-pyridin-3-yl)-2- hydroxymethyl-piperazin-1-yl]-[5-(4- fluoro-phenoxy)-4-methoxy-pyridin-2-yl]- methanone
21
[4-(6-Amino-5-methoxy-pyridazin-3-yl)- piperidin-1-yl]-(4-methoxy-5-phenoxy- pyridin-2-yl)-methanone
22
(6-Amino-3′,4′,5′,6′-tetrahydro-2′H- [3,4′]bipyridinyl-1′-yl)-[4-methoxy-5-(4- methoxy-phenoxy)-pyridin-2-yl]- methanone
23
(6-Amino-4-methoxy-3′,4′,5′,6′-tetrahydro- 2′H-[3,4′]bipyridinyl-1′-yl)-(4-methoxy-5- phenoxy-pyridin-2-yl)-methanone
24
(6-Amino-4-methoxy-3′,4′,5′,6′-tetrahydro- 2′H-[3,4′]bipyridinyl-1′-yl)-[4-methoxy-5- (4-trifluoromethyl-phenoxy)-pyridin-2-yl]- methanone
25
[4-(6-Amino-pyridazin-3-yl)-piperidin-1-yl]- (5-cyclobutylmethoxy-4-methoxy-pyridin- 2-yl)-methanone
26
(6-Amino-4-methoxy-3′,4′,5′,6′-tetrahydro- 2′H-[3,4′]bipyridinyl-1′-yl)-[4-methoxy-5- (1-methyl-cyclopropylmethoxy)-pyridin-2- yl]-methanone
27
[(R)-4-(6-Amino-4-methoxy-pyridin-3-yl)- 2-methoxymethyl-piperazin-1-yl]-(4- methoxy-5-phenoxy-pyridin-2-yl)-methanone
28
(6-Amino-4-methoxy-3′,4′,5′,6′-tetrahydro- 2′H-[3,4′]bipyridinyl-1′-yl)-[4-methoxy-5- (4-methoxy-phenoxy)-pyridin-2-yl]- methanone
29
[4-(6-Amino-4-methyl-pyridazin-3-yl)- piperidin-1-yl]-[5-(4-fluoro-phenoxy)-4- methoxy-pyridin-2-yl]-methanone
30
(6-Amino-4-methoxy-3′,4′,5′,6′-tetrahydro- 2′H-[3,4′]bipyridinyl-1′-yl)-(5- cyclohexyloxy-4-methoxy-pyridin-2-yl)- methanone
31
[4-(6-Amino-4-methyl-pyridazin-3-yl)- piperidin-1-yl]-(4-methoxy-5-phenoxy- pyridin-2-yl)-methanone
32
(6-Amino-4-methoxy-3′,4′,5′,6′-tetrahydro- 2′H-[3,4′]bipyridinyl-1′-yl)-[5-(4-fluoro- benzyloxy)-4-methoxy-pyridin-2-yl]- methanone
33
[4-(6-Amino-pyridazin-3-yl)-piperidin-1-yl]- [4-methoxy-5-(4-trifluoromethyl-phenoxy)- pyridin-2-yl]-methanone
34
[4-(6-Amino-pyridazin-3-yl)-piperidin-1-yl]- [5-(4-chloro-phenoxy)-4-methoxy-pyridin- 2-yl]-methanone
35
(6-Amino-4-methoxy-3′,4′,5′,6′-tetrahydro- 2′H-[3,4′]bipyridinyl-1′-yl)-(5- cyclopentyloxy-4-methoxy-pyridin-2-yl)- methanone
36
[4-(6-Amino-pyridazin-3-yl)-piperidin-1-yl]- (5-isobutoxy-4-methoxy-pyridin-2-yl)- methanone
37
(6-Amino-4-methoxy-3′,4′,5′,6′-tetrahydro- 2′H-[3,4′]bipyridinyl-1′-yl)-(5- cyclopropylmethoxy-4-methoxy-pyridin-2- yl)-methanone
38
[3-(6-Amino-4-methoxy-pyridin-3-yl)-3,8- diaza-bicyclo[3.2.1]oct-8-yl]-[5-(4-fluoro- phenoxy)-4-methoxy-pyridin-2-yl]- methanone
39
(6-Amino-4-methoxy-3′,4′,5′,6′-tetrahydro- 2′H-[3,4′]bipyridinyl-1′-yl)-(5-isobutoxy-4- methoxy-pyridin-2-yl)-methanone
40
[4-(6-Amino-pyridazin-3-yl)-piperidin-1-yl]- [5-(4-cyclopropoxy-phenoxy)-4-methoxy- pyridin-2-yl]-methanone
41
[4-(6-Amino-pyridazin-3-yl)-piperidin-1-yl]- [5-(4-fluoro-benzyloxy)-4-methoxy-pyridin- 2-yl]-methanone
42
[(R)-4-(6-Amino-4-methoxy-pyridin-3-yl)-2- hydroxymethyl-piperazin-1-yl]-[5-(4-fluoro- phenoxy)-4-methoxy-pyridin-2-yl]- methanone
43
(6-Amino-4-methoxy-3′,4′,5′,6′-tetrahydro- 2′H-[3,4′]bipyridinyl-1′-yl)-(5-benzyloxy-4- methoxy-pyridin-2-yl)-methanone
44
[4-(6-Amino-pyridazin-3-yl)-piperidin-1-yl]- [4-methoxy-5-(4-methoxy-phenoxy)- pyridin-2-yl]-methanone
45
(6-Amino-4-methoxy-3′,4′,5′,6′-tetrahydro- 2′H-[3,4′]bipyridinyl-1′-yl)-[5-(3,3-difluoro- cyclobutylmethoxy)-4-methoxy-pyridin-2- yl]-methanone
46
(6-Amino-4-methoxy-3′,4′,5′,6′-tetrahydro- 2′H-[3,4′]bipyridinyl-1′-yl)-(4-methoxy-5- propoxy-pyridin-2-yl)-methanone
47
[4-(6-Amino-4-methoxy-pyridazin-3-yl)- piperidin-1-yl]-(4-methoxy-5-phenoxy- pyridin-2-yl)-methanone
48
(6-Amino-4-methoxy-3′,4′,5′,6′-tetrahydro- 2′H-[3,4′]bipyridinyl-1′-yl)-[5-(2-cyclopropyl- ethoxy)-4-methoxy-pyridin-2-yl]- methanone
49
[4-(6-Amino-4-methoxy-pyridazin-3-yl)- piperidin-1-yl]-[5-(4-fluoro-phenoxy)-4- methoxy-pyridin-2-yl]-methanone
50
(1R)-1 -[(2R)-4-(6-amino-4-methoxypyridin- 3-yl)-1-(5-phenoxypyridine-2- carbonyl)piperazin-2-yl]ethan-1-ol
51
[3-(6-Amino-4-methoxy-pyridin-3-yl)-3,8- diaza-bicyclo[3.2.1]oct-8-yl]-(4-methoxy-5- phenoxy-pyridin-2-yl)-methanone
52
(6-Amino-4-methoxy-3′,4′,5′,6′-tetrahydro- 2′H-[3,4′]bipyridinyl-1′-yl)-(4-methoxy-5- phenethyloxy-pyridin-2-yl)-methanone
53
(6-Amino-4-methoxy-3′,4′,5′,6′-tetrahydro- 2′H-[3,4′]bipyridinyl-1′-yl)-(5- cyclobutylmethoxy-4-methoxy-pyridin-2- yl)-methanone
54
[4-(6-Amino-pyridazin-3-yl)-piperidin-1-yl]- [5-(4-difluoromethoxy-phenoxy)-4- methoxy-pyridin-2-yl]-methanone
55
[(R)-4-(6-Amino-4-methoxy-pyridin-3-yl)-2- methoxymethyl-piperazin-1-yl]-[5-(4-fluoro- phenoxy)-4-methoxy-pyridin-2-yl]- methanone
56
[4-(6-Amino-4-methoxy-pyridazin-3-yl)- piperidin-1-yl]-[4-methoxy-5-(4- trifluoromethyl-phenoxy)-pyridin-2-yl]- methanone
57
[4-(6-Amino-pyridazin-3-yl)-piperidin-1-yl]- [5-(2-fluoro-benzyloxy)-4-methoxy-pyridin- 2-yl]-methanone
58
(1S)-1-[(2R)-4-(6-amino-4-methoxypyridin- 3-yl)-1-(5-phenoxypyridine-2- carbonyl)piperazin-2-yl]ethan-1-ol
59
(6-Amino-4-methoxy-3′,4′,5′,6′-tetrahydro- 2′H-[3,4′]bipyridinyl-1′-yl)-[5-(2,2-dimethyl- propoxy)-4-methoxy-pyridin-2-yl]- methanone
60
[4-(6-Amino-5-methoxy-pyridazin-3-yl)- piperidin-1-yl]-[4-methoxy-5-(4-methoxy- phenoxy)-pyridin-2-yl]-methanone
61
[4-(6-Amino-4-methoxy-pyridin-3-yl)- piperazin-1-yl]-(5-cyclopropylmethoxy-4- methoxy-pyridin-2-yl)-methanone
62
[4-(6-Amino-pyridazin-3-yl)-piperidin-1-yl]- (5-cyclohexyloxy-4-methoxy-pyridin-2-yl)- methanone
63
[(S)-4-(6-Amino-4-methoxy-pyridin-3-yl)-2- hydroxymethyl-piperazin-1-yl]-[5-(4-fluoro- phenoxy)-4-methoxy-pyridin-2-yl]- methanone
64
(6-Amino-4-methoxy-3′,4′,5′,6′-tetrahydro- 2′H-[3,4′]bipyridinyl-1′-yl)-[5-(1- fluoromethyl-cyclopropylmethoxy)-4- methoxy-pyridin-2-yl]-methanone
65
(6-Amino-4-methoxy-3′,4′,5′,6′-tetrahydro- 2′H-[3,4′]bipyridinyl-1′-yl)-(5-ethoxy-4- methoxy-pyridin-2-yl)-methanone
66
[4-(6-Amino-4-methoxy-pyridazin-3-yl)- piperidin-1-yl]-[4-methoxy-5-(4-methoxy- phenoxy)-pyridin-2-yl]-methanone
67
[4-(6-Amino-pyridazin-3-yl)-piperidin-1-yl]- [5-(2-cyclopropyl-ethoxy)-4-methoxy- pyridin-2-yl]-methanone
68
[7-(6-Amino-4-methoxy-pyridin-3-yl)-3- oxa-9-aza-bicyclo[3.3.1]non-9-yl]-(4- methoxy-5-phenoxy-pyridin-2-yl)- methanone
69
[(R)-4-(6-Amino-4-methoxy-pyridin-3-yl)-2- hydroxymethyl-piperazin-1-yl]-(4-methoxy- 5-phenoxy-pyridin-2-yl)-methanone
70
(6-Amino-4-methoxy-3′,4′,5′,6′-tetrahydro- 2′H-[3,4′]bipyridinyl-1′-yl)-[5-((S)-1- cyclopropyl-ethoxy)-4-methoxy-pyridin-2- yl]-methanone
71
[(S)-4-(6-Amino-4-methoxy-pyridin-3-yl)-2- hydroxymethyl-piperazin-1-yl]-(4-methoxy- 5-phenoxy-pyridin-2-yl)-methanone
72
(6-Amino-4-methoxy-3′,4′,5′,6′-tetrahydro- 2′H-[3,4′]bipyridinyl-1′-yl)-(5-isopropoxy-4- methoxy-pyridin-2-yl)-methanone
73
[4-(6-Amino-pyridazin-3-yl)-piperidin-l-yl]- (4-methoxy-5-phenethyloxy-pyridin-2-yl)- methanone
74
[4-(6-Amino-pyridazin-3-yl)-piperidin-1-yl]- [5-(2,2-dimethyl-propoxy)-4-methoxy- pyridin-2-yl]-methanone
75
[4-(6-Amino-pyridazin-3-yl)-piperidin-l-yl]- [4-methoxy-5-(1-methyl- cyclopropylmethoxy)-pyridin-2-yl]- methanone
76
[4-(6-Amino-pyridazin-3-yl)-piperidin-1-yl]- (4-methoxy-5-propoxy-pyridin-2-yl)- methanone
77
(6-Amino-4-methoxy-3′,4′,5′,6′-tetrahydro- 2′H-[3,4′]bipyridinyl-1′-yl)-[5-((R)-1- cyclopropyl-ethoxy)-4-methoxy-pyridin-2- yl]-methanone
78
[4-(6-Amino-4-methyl-pyridazin-3-yl)- piperidin-1-yl]-(5-cyclopropylmethoxy-4- methoxy-pyridin-2-yl)-methanone
79
[4-(6-Amino-pyridazin-3-yl)-piperidin-1-yl]- [5-((S)-1-cyclopropyl-ethoxy)-4-methoxy- pyridin-2-yl]-methanone
80
[4-(6-Amino-pyridazin-3-yl)-piperidin-1-yl]- [4-methoxy-5-(4-trifluoromethoxy- phenoxy)-pyridin-2-yl]-methanone
81
[(R)-4-(6-Am ino-pyridin-3-yl)-2- hydroxymethyl-piperazin-1-yl]-(4-methoxy- 5-phenoxy-pyridin-2-yl)-methanone
82
[(R)-4-(6-Amino-pyridin-3-yl)-2- hydroxymethyl-piperazin-1-yl]-[4-methoxy- 5-(4-methoxy-phenoxy)-pyridin-2-yl]- methanone
83
[4-(6-Amino-pyridazin-3-yl)-piperidin-1-yl]- [5-(phenoxy)-4-ethoxy-pyridin-2-yl]- methanone
84
(6-Am ino-4-cyclopropoxy-3′,4′,5′,6′- tetrahydro-2′H-[3,4′]bipyridinyl-1′-yl)-[5- (phenoxy)-4-methoxy-pyridin-2-yl]- methanone
85
[4-(6-Amino-4-ethoxy-pyridazin-3-yl)- piperidin-1-yl]-[4-methoxy-5-(phenoxy)- pyridin-2-yl]-methanone
86
(6-Amino-4-propoxy-3′,4′,5′,6′-tetrahydro- 2′H-[3,4′]bipyridinyl-1′-yl)-[5-(phenoxy)-4- methoxy-pyridin-2-yl]-methanone
87
5-ethoxy-6-(1-[4-methoxy-5-[4- (trifluoromethyl)phenoxy]pyridine-2- carbonyl]piperidin-4-yl)pyridazine-3-amine
88
[4-(6-Amino-pyridazin-3-yl)-piperidin-l-yl]- [5-(4-fluoro-phenoxy)-4-ethoxy-pyridin-2- yl]-methanone
89
[3-(6-Amino-pyridazin-3-yl)-8-aza- bicyclo[3.2.1]oct-8-yl]-[4-ethoxy-5-(4- fluoro-phenoxy)-pyridin-2-yl]-methanone
90
6-(1-{4-Methoxy-5-[4- (trifluoromethyl)phenoxy]pyridine-2- carbonyl}piperidin-4-yl)-5-methylpyridazin- 3-amine
91
5-Methoxy-6-(1-{5-[4-(trifluoromethyl)- phenoxy]-pyridine-2-carbonyl}piperidin-4- yl)-pyridazin-3-amine
92
4-methoxy-5-[1-(4-methoxy-5-[trans-3- (trifluoromethyl)cyclobutylmethoxy]pyridine- 2-carbonyl)piperidin-4-yl]-pyridin-2-amine
93
4-methoxy-5-[1-(4-methoxy-5-[cis-3- (trifluoromethyl)cyclobutylmethoxy]pyridine- 2-carbonyl)pipenclin-4-yl]-pyridin-2-amine
94
4-methoxy-5-[1-(4-methoxy-5-[3,3,3- trifluoro-2-methylpropoxy]pyridine-2- carbonyl)piperidin-4-yl]-pyridin-2-amine
95
5-(1-{5-[(2,2-Difluorocyclobutyl)-methoxy]- 4-methoxy-pyridine-2-carbonyl}-piperidin- 4-yl)-4-methoxypyridin-2-amine;
or a pharmaceutically acceptable salt thereof.
14 . The method of claim 13 , wherein the compound is selected from the group consisting of:
[4-(6-Amino-pyridazin-3-yl)-piperidin-1-yl]-[5-(4-isopropoxy-phenoxy)-4-methoxy-pyridin-2-yl]-methanone; [4-(6-Amino-pyridazin-3-yl)-piperidin-1-yl]-(4-methoxy-5-phenoxy-pyridin-2-yl)-methanone; [4-(6-Amino-pyridazin-3-yl)-piperidin-1-yl]-[5-(4-fluoro-phenoxy)-4-methoxy-pyridin-2-yl]-methanone; [4-(6-Amino-pyridazin-3-yl)-piperidin-1-yl]-[4-methoxy-5-(4-trifluoromethyl-phenoxy)-pyridin-2-yl]-methanone; [4-(6-Amino-pyridazin-3-yl)-piperidin-1-yl]-[5-(4-chloro-phenoxy)-4-methoxy-pyridin-2-yl]-methanone; [4-(6-Amino-pyridazin-3-yl)-piperidin-1-yl]-[5-(4-cyclopropoxy-phenoxy)-4-methoxy-pyridin-2-yl]-methanone; [4-(6-Amino-pyridazin-3-yl)-piperidin-1-yl]-[5-(4-fluoro-benzyloxy)-4-methoxy-pyridin-2-yl]-methanone; [4-(6-Amino-pyridazin-3-yl)-piperidin-1-yl]-[4-methoxy-5-(4-methoxy-phenoxy)-pyridin-2-yl]-methanone; [4-(6-Amino-pyridazin-3-yl)-piperidin-1-yl]-[5-(4-difluoromethoxy-phenoxy)-4-methoxy-pyridin-2-yl]-methanone; [4-(6-Amino-pyridazin-3-yl)-piperidin-1-yl]-[5-(2-fluoro-benzyloxy)-4-methoxy-pyridin-2-yl]-methanone; [4-(6-Amino-pyridazin-3-yl)-piperidin-1-yl]-[4-methoxy-5-(4-trifluoromethoxy-phenoxy)-pyridin-2-yl]-methanone; [4-(6-Amino-pyridazin-3-yl)-piperidin-1-yl]-[5-(phenoxy)-4-ethoxy-pyridin-2-yl]-methanone; and [4-(6-Amino-pyridazin-3-yl)-piperidin-1-yl]-[5-(4-fluoro-phenoxy)-4-ethoxy-pyridin-2-yl]-methanone; or a pharmaceutically acceptable salt thereof.
15 . The method of claim 14 , wherein the compound is selected from the group consisting of:
[4-(6-Amino-pyridazin-3-yl)-piperidin-1-yl]-[5-(4-isopropoxy-phenoxy)-4-methoxy-pyridin-2-yl]-methanone; [4-(6-Amino-pyridazin-3-yl)-piperidin-1-yl]-(4-methoxy-5-phenoxy-pyridin-2-yl)-methanone; [4-(6-Amino-pyridazin-3-yl)-piperidin-1-yl]-[5-(4-fluoro-phenoxy)-4-methoxy-pyridin-2-yl]-methanone; [4-(6-Amino-pyridazin-3-yl)-piperidin-1-yl]-[4-methoxy-5-(4-trifluoromethyl-phenoxy)-pyridin-2-yl]-methanone; [4-(6-Amino-pyridazin-3-yl)-piperidin-1-yl]-[5-(4-chloro-phenoxy)-4-methoxy-pyridin-2-yl]-methanone; [4-(6-Amino-pyridazin-3-yl)-piperidin-1-yl]-[5-(4-cyclopropoxy-phenoxy)-4-methoxy-pyridin-2-yl]-methanone; [4-(6-Amino-pyridazin-3-yl)-piperidin-1-yl]-[5-(4-fluoro-benzyloxy)-4-methoxy-pyridin-2-yl]-methanone; [4-(6-Amino-pyridazin-3-yl)-piperidin-1-yl]-[4-methoxy-5-(4-methoxy-phenoxy)-pyridin-2-yl]-methanone; [4-(6-Amino-pyridazin-3-yl)-piperidin-1-yl]-[5-(4-difluoromethoxy-phenoxy)-4-methoxy-pyridin-2-yl]-methanone; [4-(6-Amino-pyridazin-3-yl)-piperidin-1-yl]-[5-(2-fluoro-benzyloxy)-4-methoxy-pyridin-2-yl]-methanone; [4-(6-Amino-pyridazin-3-yl)-piperidin-1-yl]-[4-methoxy-5-(4-trifluoromethoxy-phenoxy)-pyridin-2-yl]-methanone; [4-(6-Amino-pyridazin-3-yl)-piperidin-1-yl]-[5-(phenoxy)-4-ethoxy-pyridin-2-yl]-methanone; and [4-(6-Amino-pyridazin-3-yl)-piperidin-1-yl]-[5-(4-fluoro-phenoxy)-4-ethoxy-pyridin-2-yl]-methanone.
16 . The compound according to claim 13 , wherein the compound is selected from the group consisting of:
[4-(6-Amino-4-methyl-pyridazin-3-yl)-piperidin-1-yl]-[5-(4-fluoro-phenoxy)-4-methoxy-pyridin-2-yl]-methanone; [4-(6-Amino-4-methyl-pyridazin-3-yl)-piperidin-1-yl]-(4-methoxy-5-phenoxy-pyridin-2-yl)-methanone; [4-(6-Amino-4-methoxy-pyridazin-3-yl)-piperidin-1-yl]-[5-(4-fluoro-phenoxy)-4-methoxy-pyridin-2-yl]-methanone; [4-(6-Amino-4-methoxy-pyridazin-3-yl)-piperidin-1-yl]-[4-methoxy-5-(4-trifluoromethyl-phenoxy)-pyridin-2-yl]-methanone; [4-(6-Amino-4-methoxy-pyridazin-3-yl)-piperidin-1-yl]-[4-methoxy-5-(4-methoxy-phenoxy)-pyridin-2-yl]-methanone; [4-(6-Amino-4-ethoxy-pyridazin-3-yl)-piperidin-1-yl]-[4-methoxy-5-(phenoxy)-pyridin-2-yl]-methanone; 5-ethoxy-6-(1-[4-methoxy-5-[4-(trifluoromethyl)phenoxy]pyridine-2-carbonyl]piperidin-4-yl)pyridazine-3-amine; and 6-(1-{4-Methoxy-5-[4-(trifluoromethyl)phenoxy]pyridine-2-carbonyl}piperidin-4-yl)-5-methylpyridazin-3-amine; or a pharmaceutically acceptable salt thereof.
17 . The compound according to claim 16 , wherein the compound is selected from the group consisting of:
[4-(6-Amino-4-methyl-pyridazin-3-yl)-piperidin-1-yl]-[5-(4-fluoro-phenoxy)-4-methoxy-pyridin-2-yl]-methanone; [4-(6-Amino-4-methyl-pyridazin-3-yl)-piperidin-1-yl]-(4-methoxy-5-phenoxy-pyridin-2-yl)-methanone; [4-(6-Amino-4-methoxy-pyridazin-3-yl)-piperidin-1-yl]-[5-(4-fluoro-phenoxy)-4-methoxy-pyridin-2-yl]-methanone; [4-(6-Amino-4-methoxy-pyridazin-3-yl)-piperidin-1-yl]-[4-methoxy-5-(4-trifluoromethyl-phenoxy)-pyridin-2-yl]-methanone; [4-(6-Amino-4-methoxy-pyridazin-3-yl)-piperidin-1-yl]-[4-methoxy-5-(4-methoxy-phenoxy)-pyridin-2-yl]-methanone; [4-(6-Amino-4-ethoxy-pyridazin-3-yl)-piperidin-1-yl]-[4-methoxy-5-(phenoxy)-pyridin-2-yl]-methanone; 5-ethoxy-6-(1-[4-methoxy-5-[4-(trifluoromethyl)phenoxy]pyridine-2-carbonyl]piperidin-4-yl)pyridazine-3-amine; and 6-(1-{4-Methoxy-5-[4-(trifluoromethyl)phenoxy]pyridine-2-carbonyl}piperidin-4-yl)-5-methylpyridazin-3-amine.
18 . The method of claim 13 , wherein the cancer is brain cancer.
19 . The method of claim 18 , wherein the brain cancer is glioblastoma multiforme.
20 . The method of claim 18 , wherein the brain cancer is a glioma.
21 . The method of claim 13 , wherein the cancer is breast cancer.
22 . The method of claim 13 , wherein the cancer is kidney cancer.
23 . The method of claim 22 , wherein the kidney cancer is renal cell carcinoma.
24 . The method of claim 13 , wherein the cancer is cervical cancer.
25 . The method of claim 13 , wherein the cancer is prostate cancer.
26 . The method of claim 13 , wherein the cancer is gastrointestinal cancer.
27 . The method of claim 26 , wherein the gastrointestinal cancer is esophageal squamous cell carcinoma.
28 . The method of claim 13 , wherein the cancer is skin cancer.
29 . The method of claim 28 , wherein the skin cancer is squamous cell carcinoma.
30 . The method of claim 13 , wherein the cancer is epithelial cancer.Join the waitlist — get patent alerts
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