Compositions for treatment of xerostomia and for tooth treatment

Abstract

The present application provides an oral care composition comprising: a) one or more omega fatty acids; and one or more of the following: b) one or more emulsifying agents; c) one or more protease enzymes; d) one or more soluble calcium phosphate remineralizing agents; e) one or more amino acids.

What is claimed is: 
     
         1 . An oral care composition comprising:
 a) emu oil;   and one or more of the following:   b) one or more emulsifying agents;   c) one or more protease enzymes;   d) one or more soluble calcium phosphate remineralizing agents;   e) one or more amino acids.   
     
     
         2 . The composition of  claim 1  comprising:
 a) emu oil; 
 and two or more of the following: 
 b) one or more emulsifying agents; 
 c) one or more protease enzymes; 
 d) one or more soluble calcium phosphate remineralizing agents; 
 e) one or more amino acids. 
 
     
     
         3 . The composition of  claim 2  comprising:
 a) emu oil; 
 and three or more of the following: 
 b) one or more emulsifying agents; 
 c) one or more protease enzymes; 
 d) one or more soluble calcium phosphate remineralizing agents; 
 e) one or more amino acids. 
 
     
     
         4 . The composition of  claim 3  comprising:
 a) emu oil; 
 b) one or more emulsifying agents; 
 c) one or more protease enzymes; 
 d) one or more soluble calcium phosphate remineralizing agents; 
 e) one or more amino acids. 
 
     
     
         5 . The composition of  claim 4 , wherein one or more of the protease enzymes are selected from the group consisting of stem bromelain, papain, trypsin, chymotrypsin, aminopeptidase, carboxypeptidase, pepsin, and cathepsin. 
     
     
         6 . The composition of  claim 4 , wherein the one or more amino acids are selected from the group consisting of arginine and glutamine. 
     
     
         7 . The composition of  claim 4 , wherein the one or more soluble calcium phosphate remineralizing agents are selected from the group consisting of amorphous calcium phosphate, dibasic calcium phosphate, monocalcium phosphate, tricalcium phosphate, and tetracalcium phosphate. 
     
     
         8 . The composition of  claim 7 , wherein the one or more emulsifying agents are phospholipids. 
     
     
         9 . The composition of  claim 8 , wherein at least one of the phospholipids is soy lecithin. 
     
     
         10 . The composition of  claim 4 , wherein the composition further comprises an isomalt. 
     
     
         11 . The composition of  claim 10 , wherein the isomalt is selected from the group consisting of galenIQ™ 720 and galenIQ™ 721. 
     
     
         12 . The composition of  claim 4 , wherein the composition further comprises a disintegrating agent. 
     
     
         13 . The composition of  claim 12 , wherein the disintegrating agent is crospovidone. 
     
     
         14 . The composition of  claim 4 , wherein the composition further comprises magnesium stearate. 
     
     
         15 . The composition of  claim 4 , wherein the composition further comprises glycerin. 
     
     
         16 . The composition of  claim 4 , wherein the composition further comprises fluoride. 
     
     
         17 . The composition of  claim 4 , wherein the remineralizing agent is white in color. 
     
     
         18 . The composition of any one  claims 1 - 17 , wherein the composition is formulated as a tablet, a bilayer tablet, a multilayer tablet, chewing gum, a toothpaste, a lozenge, a powder, a gel, a viscous gel, an ointment, a cream, a liquid, a mouthwash, or a candy. 
     
     
         19 . The composition of  claim 18 , wherein the composition is formulated as a tablet. 
     
     
         20 . The composition of  claim 19 , wherein the amino acids are present only in the coating of the tablet. 
     
     
         21 . The composition of  claim 18 , wherein the composition is formulated as a bilayer tablet. 
     
     
         22 . The composition of  claim 19 , wherein the amino acids are present only in a single layer of the bilayer tablet. 
     
     
         23 . The composition of any one of  claims 1 - 22 , wherein the composition comprises the amino acids in an amount between 0.01 to 25% by weight. 
     
     
         24 . The composition of any one of  claims 1 - 22 , wherein the composition comprises the amino acids in an amount between 1 to 20% by weight. 
     
     
         25 . The composition of any one of  claims 1 - 22 , wherein the composition comprises the amino acids in an amount of 10 to 15% by weight. 
     
     
         26 . The composition of any one of  claims 1 - 22 , wherein the composition comprises the amino acids in an amount of 5 to 10% by weight. 
     
     
         27 . The composition of any one of  claims 1 - 22 , wherein the composition comprises the amino acids in an amount of 1 to 5% by weight. 
     
     
         28 . The composition of any one of  claims 1 - 22 , wherein the composition comprises the amino acids in an amount of 0.01 to 1% by weight. 
     
     
         29 . The composition of any one of  claims 1 - 22 , wherein the composition comprises the amino acids in an amount of 0.01 to 0.5% by weight. 
     
     
         30 . The composition of anyone of  claims 1 - 29 , wherein the emu oil is Black emu oil or Baramol emu oil. 
     
     
         31 . The composition of any one of  claims 1 - 30 , wherein the composition comprises emu oil in an amount between 6 to 10% by weight. 
     
     
         32 . The composition of  claim 31 , wherein the composition comprises emu oil in an amount between 8 to 10 by weight. 
     
     
         33 . The composition of  claim 31 , wherein the composition comprises emu oil in an amount of 10V by weight. 
     
     
         34 . The composition of any one of  claims 1 - 33 , wherein the composition comprises the remineralizing agent in an amount between 5 to 10% by weight. 
     
     
         35 . The composition of  claim 34 , wherein the composition comprises the remineralizing agent in an amount of 10% by weight. 
     
     
         36 . The composition of any one of  claims 1 - 35 , wherein the composition comprises the emulsifying agent in an amount between 1 to 10% by weight. 
     
     
         37 . The composition of  claim 36 , wherein the composition comprises the emulsifying agent in an amount between 2 to 4% by weight. 
     
     
         38 . The composition of  claim 36 , wherein the composition comprises the emulsifying agent in an amount of 10% by weight. 
     
     
         39 . The composition of any one of  claims 1 - 38 , wherein the composition comprises the protease enzyme in an amount between 1 to 10 1  by weight. 
     
     
         40 . The composition of  claim 39 , wherein the composition comprises the protease enzyme in an amount between 5 to 10% by weight. 
     
     
         41 . The composition of  claim 39 , wherein the composition comprises the protease enzyme in an amount of 5 by weight. 
     
     
         42 . The composition of any one of  claims 1 - 41  further comprising a sweetener, colorant or flavoring agent. 
     
     
         43 . The composition of any one of  claims 1 - 42  further comprising polyethylene glycol. 
     
     
         44 . The composition of any one of  claims 1 - 43 , wherein the composition is a liposome. 
     
     
         45 . The composition of any one of  claims 1 - 43 , wherein the composition is a micelle. 
     
     
         46 . The composition of  claim 44 , wherein the one or more proteases are contained in the liposome. 
     
     
         47 . The composition of  claim 46 , wherein the one or more proteases are encapsulated by the liposome. 
     
     
         48 . The composition of  claim 1 , comprising
 a) 10% by weight emu oil;   b) 2% by weight one or more emulsifying agents;   c) 5 by weight one or more protease enzymes;   d) 5% by weight one or more soluble calcium phosphate remineralizing agents;   e) 10% by weight water; and   f) about 68% by weight polyethylene glycol.   
     
     
         49 . The composition of  claim 1 , comprising
 a) 10% by weight black emu oil;   b) 2% by weight one or more emulsifying agents;   c) 5% by weight one or more protease enzymes;   d) 5% by weight one or more soluble calcium phosphate remineralizing agents;   e) 10% by weight water; and   f) about 68% by weight polyethylene glycol.   
     
     
         50 . The composition of  claim 1 , comprising
 a) 10% by weight emu oil;   b) 2% by weight soy lecithin;   c) 5% by weight bromelain;   d) 5 by weight amorphous calcium phosphate;   e) 10% by weight water; and   f) about 68% by weight polyethylene glycol.   
     
     
         51 . The composition of  claim 1 , comprising
 a) 10% by weight black emu oil;   b) 2 by weight soy lecithin;   C) 5% by weight bromelain;   d) 5% by weight amorphous calcium phosphate;   e) 10% by weight water; and   f) about 68% by weight polyethylene glycol.   
     
     
         52 . The composition of  claim 1 , comprising
 a) about 10% by weight emu oil;   b) about 23 by weight one or more emulsifying agents;   c) about 5% by weight one or more protease enzymes;   d) about 5% by weight one or more soluble calcium phosphate remineralizing agents;   e) about 10% by weight water; and   f) about 68% by weight polyethylene glycol.   
     
     
         53 . The composition of  claim 1 , comprising
 a) about 10% by weight black emu oil;   b) about 2% by weight one or more emulsifying agents;   c) about 5% by weight one or more protease enzymes;   d) about 5% by weight one or more soluble calcium phosphate remineralizing agents;   e) about 10% by weight water; and   f) about 68% by weight polyethylene glycol.   
     
     
         54 . The composition of  claim 1 , comprising
 a) about 10% by weight emu oil;   b) about 2 by weight soy lecithin;   c) about 5% by weight bromelain;   d) about 5% by weight amorphous calcium phosphate;   e) about 10% by weight water; and   f) about 68% by weight polyethylene glycol.   
     
     
         55 . The composition of  claim 1 , comprising
 a) about 10% by weight black emu oil;   b) about 2% by weight soy lecithin;   c) about 5% by weight bromelain;   d) about 5% by weight amorphous calcium phosphate;   e) about 10% by weight water; and   f) about 68% by weight polyethylene glycol.   
     
     
         56 . An oral care composition comprising:
 a) one or more omega fatty acids;   and one or more of the following:   b) one or more emulsifying agents;   c) one or more protease enzymes;   d) one or more soluble calcium phosphate remineralizing agents;   e) one or more amino acids.   
     
     
         57 . The composition of  claim 56  comprising:
 a) one or more omega fatty acids; 
 and two or more of the following: 
 b) one or more emulsifying agents; 
 c) one or more protease enzymes; 
 d) one or more soluble calcium phosphate remineralizing agents; 
 e) one or more amino acids. 
 
     
     
         58 . The composition of  claim 57  comprising:
 a) one or more omega fatty acids; 
 and three or more of the following: 
 b) one or more emulsifying agents; 
 c) one or more protease enzymes; 
 d) one or more soluble calcium phosphate remineralizing agents; 
 e) one or more amino acids. 
 
     
     
         59 . The composition of  claim 58  comprising:
 a) one or more omega fatty acids; 
 b) one or more emulsifying agents; 
 c) one or more protease enzymes; 
 d) one or more soluble calcium phosphate remineralizing agents; 
 e) one or more amino acids. 
 
     
     
         60 . A method of treating a subject suffering from xerostomia which comprises administering to the subject, in an amount effective to treat the xerostomia, a composition of any one of  claims 1 - 59 . 
     
     
         61 . A method of treating a subject suffering from mucositis which comprises administering to the subject, in an amount effective to treat the mucositis, a composition of any one of  claims 1 - 59 . 
     
     
         62 . The method of  claim 60  or  61 , wherein the composition remineralizes teeth in the subject's mouth. 
     
     
         63 . The method of  claim 60  or  61 , wherein the composition reduces inflammation in the subject's mouth. 
     
     
         64 . The method of  claim 60  or  61 , wherein the composition lubricates the subject's mouth. 
     
     
         65 . The method of  claim 60  or  61 , wherein the composition reconditions the dental pellicle in the subject's mouth. 
     
     
         66 . The method of  claim 60  or  61 , wherein the composition provides a soothing effect in the subject's mouth. 
     
     
         67 . The method of  claim 60  or  61 , wherein the composition prevents caries the subject's mouth. 
     
     
         68 . The method of any one of  claims 60 - 67 , wherein the subject is a human. 
     
     
         69 . The method of  claim 68 , wherein the subject has an autoimmune disease, diabetes, Sjögren's syndrome, or has recently undergone radiation therapy or chemotherapy. 
     
     
         70 . The method of any one of  claims 60 - 69 , wherein the subject is concurrently taking one or more medications that causes xerostomia.