Fasting mimicking and enhancing diet for treating hypertension and lipid disorders

Abstract

Methods for lowering hypertension, elevated total cholesterol, elevated glucose and insulin, elevated IGF-1, elevated triglyceride levels, and/or elevated CRP levels, and elevated liver fat without negatively affecting or lowering the levels of these markers/factors in subjects with already low levels of these markers are provided. A method for elevating stem cells and regeneration and anti-inflammatory agents is also provided. Finally, a method for treating metabolic syndrome is also provided. A hypocaloric or calorie free diet or a fasting mimicking diet is administered for a first time period to the subject to reduce blood pressure or the levels of the above markers/risk factors for aging and age-related diseases.

1 - 5 . (canceled) 
     
     
         6 . A method for reducing elevated cholesterol levels and/or elevated LDL levels without lowering HDL levels, the method comprising:
 a) identifying a subject having elevated cholesterol levels and/or elevated LDL levels; and   b) administering short-term hypocaloric or calorie free diet or a fasting mimicking diet (FMD) to the subject for a first time period to reduce elevated cholesterol levels and/or elevated LDL levels.   
     
     
         7 . The method of  claim 6  wherein the hypocaloric or calorie free diet or fasting mimicking diet is administered for a period of 5 days every 2-12 weeks or 1-2 days every week. 
     
     
         8 . The method of  claim 6  wherein step b) is repeated a plurality of times at predetermined intervals. 
     
     
         9 . The method of  claim 8  wherein step b) is repeated at intervals from one week to 6 months. 
     
     
         10 . The method of  claim 8  wherein the subject is administered a normal diet in between repetition of step b). 
     
     
         11 . A method for reducing elevated triglyceride levels and/or elevated CRP levels, the method comprising:
 a) identifying a subject having elevated triglyceride levels and/or elevated CPR levels; and   b) administering a hypocaloric or calorie free diet or a fasting mimicking diet (FMD) to the subject for a first time period to reduce elevated triglyceride levels and/or elevated CPR levels.   
     
     
         12 . The method of  claim 11  wherein the hypocaloric or calorie free diet or fasting mimicking diet (FMD) is administered for a period of 5 days every 2-12 weeks or 1-2 days every week. 
     
     
         13 . The method of  claim 11  wherein step b) is repeated a plurality of times at predetermined intervals. 
     
     
         14 . The method of  claim 13  wherein step b) is repeated at intervals from one week to 2 months. 
     
     
         15 . The method of  claim 13  wherein the subject is administered a normal diet in between repetition of step b). 
     
     
         16 - 20 . (canceled) 
     
     
         21 . A method for treating abdominal obesity without negatively affecting lean body mass, the method comprising:
 a) identifying a subject that is overweight; and   b) administering a hypocaloric or calorie free diet or a fasting mimicking diet (FMD) to the subject for a first time period to reduce fat mass without affecting lean body mass.   
     
     
         22 . The method of claim  20  wherein the hypocaloric or calorie free diet or fasting mimicking diet is administered for a period of 5 days every 2-12 weeks or 1-2 days every week. 
     
     
         23 . The method of claim  20  wherein step b) is repeated a plurality of times at predetermined intervals. 
     
     
         24 - 35 . (canceled) 
     
     
         36 . A method for reducing fatty liver, the method comprising:
 a) identifying a subject having elevated hepatic fat fraction; and   b) administering a hypocaloric or calorie free diet or a fasting mimicking diet (FMD) to the subject for a first time period to reduce hepatic fat fraction.