Antibodies targeting quiescin sulfhydryl oxidase (qsox1) and uses of same

Abstract

An antibody comprising an antigen recognition domain exhibiting species cross reactivity to human QSOX1 and murine QSOX1 is disclosed. Methods of producing the antibody, pharmaceutical compositions comprising the antibody and methods of using the antibody for treating medical conditions are also disclosed.

What is claimed is: 
     
         1 . An antibody comprising an antigen recognition domain exhibiting species cross reactivity to human QSOX1 and murine QSOX1, said antigen recognition domain comprising complementarity determining regions (CDRs) as set forth in SEQ ID NOs: 26-31. 
     
     
         2 . The antibody of  claim 1 , wherein said antibody is an antibody fragment, a single chain antibody or a monoclonal antibody. 
     
     
         3 . The antibody of  claim 2 , wherein said monoclonal antibody is Mab316.1 and comprises CDRs SEQ ID NOs: 26-31. 
     
     
         4 . The antibody of  claim 2 , wherein said single chain antibody is Mab316.1 and comprises CDRs SEQ ID NOs: 26-31. 
     
     
         5 . A pharmaceutical composition comprising as an active ingredient the monoclonal antibody of  claim 1  and a pharmaceutically acceptable carrier. 
     
     
         6 . A method for preventing or treating a laminin-associated disease or condition in a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of the pharmaceutical composition of  claim 5 .