Bioerodible matrix for tissue involvement

Abstract

The present disclosure relates to polymer implants for procedures such as reconstructive and aesthetic surgery, wound healing, and closure and protection of incision sites. The implants can include a matrix from a bioerodible biopolymer. The biopolymer can be porous and conducive to cell growth for providing a beneficial interface between the matrix and host tissue. The biopolymer can be polyurethane formulation, which can include polycaprolactone soft segments.

What is claimed is: 
     
         1 . A method comprising forming a matrix from a bioerodible polyurethane formulation, wherein the bioerodible polyurethane formulation comprises polycaprolactone soft segments. 
     
     
         2 . The method of  claim 1 , further comprising reacting polyisocyanates with polyols to synthesize the bioerodible polyurethane formulation. 
     
     
         3 . The method of  claim 2 , wherein the polyols comprise poly(ethylene oxide), poly(propylene oxide), modified polyether polyols, polytetramethylene glycol, or polycarbonate polyols. 
     
     
         4 . The method of  claim 2 , further comprising reacting dicarboxylic acids with diols to produce condensation polyester polyols. 
     
     
         5 . The method of  claim 2 , further comprising polymerizing epsilon-caprolactone to produce lactone-type polyester polyols. 
     
     
         6 . The method of  claim 2 , further comprising reacting a polyol mixture with 1,6-hexamethylene diisocyanate, isophoron diisocyanate or dicyclohexylmethane 4,4′-diisocyanate and a chain lengthener. 
     
     
         7 . The method of  claim 6 , wherein reacting the polyol mixture comprises reacting 100 parts by weight of the polyol mixture with 1,6-hexamethylene diisocyanate, isophoron diisocyanate or dicyclohexylmethane 4,4′-diisocyanate and the chain lengthener. 
     
     
         8 . The method of  claim 6 , wherein the chain lengthener comprises 1,4-butane diol or 1,6-hexane diol. 
     
     
         9 . The method of  claim 2 , wherein the polyols comprise about 70 to about 90 parts by weight of polyester polyol having a molecular weight of about 2000. 
     
     
         10 . The method of  claim 2 , wherein the polyols comprise about 10 to about 30 parts by weight of polyether polyol. 
     
     
         11 . The method of  claim 1 , further comprising seeding the matrix with stem cells. 
     
     
         12 . The method of  claim 1 , further comprising seeding the matrix with progenitor cells. 
     
     
         13 . The method of  claim 1 , wherein the polycaprolactone soft segments have an amorphous rubbery phase. 
     
     
         14 . A method comprising forming a matrix from a bioerodible biopolymer that is porous and conducive to cell growth for providing a beneficial interface between the matrix and host tissue. 
     
     
         15 . The method of  claim 14 , further comprising cross-linking the bioerodible biopolymer. 
     
     
         16 . The method of  claim 14 , further comprising changing a hydrophobicity of a side residue for the biopolymer. 
     
     
         17 . The method of  claim 14 , further comprising separating the biopolymer into a polymer phase and a solvent phase. 
     
     
         18 . The method of  claim 17 , wherein the separating the biopolymer comprises (i) thermally inducing gelation or crystallization, (ii) separating the solvent phase and the polymer phase without solvent, (iii) chemically inducing phase separation, or (iv) thermally inducing spinodal decomposition. 
     
     
         19 . The method of  claim 14 , wherein the biopolymer is selected from a group consisting of: hyaluronic acid, collagen, recombinant collagen, cellulose, elastin, alginates, chondroitin sulfate, chitosan, chitin, keratin, silk, small intestine submucosa, aliphatic polyesters, polyalkylene oxalates, polyamides, polycarbonates, polyorthoesters, polyoxaesters, polyamidoesters, polyanhydrides, polyphosphazenes, elastomeric copolymers of ε-caprolactone and glycolide, and a hydrogel polymer. 
     
     
         20 . The method of  claim 14 , wherein the matrix has a porosity between about 20 microns to about 350 microns.