Radioprotection, Radiomitigation and Radiorecovery

Abstract

Radioprotection, Radiomitigation and Radiorecovery: Timed use of more widely available antiradiation agents in a kit for subjects affected by ionizing radiation, radiomimetic exposure and radio contamination. The method in the form of strategically timed preemptive and post-irradiation compositions; radioprotection, radiomitigation and radiorecovery formulations are comprised of various available anticorporation, antioxidant, decorporation, multi-mechanistic, pro-survival, pro-hematopoietic, anti-fibrotic and other novel ingredients in synergistic mixtures to be used in critically-timed manners. Radioprotection, radiomitigation and radiorecovery of a mammal prior to, during, just after or well-after exposure to ionizing radiation energy—alpha, beta, neutron, gamma, X-ray and damaging radiofrequency radiation—for long or short periods of time, and exposure to or contamination by radioactive elements or compounds such as radioiodine, radiostrontium, radiophosphorus, radiocobalt, radiocadmium, radiopollonium, radioradium, radiocesium, radiouranium, radioamericium, radiopollonium, radiocerium, radioindium, and the like. Radiomimetic protective method for mucosal exposure is also described.

1 . A radiation, radiowave, radioisotope or radiomimetic chemical exposure countermeasure treatment kit comprised of a plurality of three compositions, wherein the first composition is comprised of radioprotection elements and which is used before said exposure, wherein the second composition is comprised of radiomitigation elements and which is used directly after said exposure, and wherein the third composition is comprised of radiorecovery elements and which is used later after said exposure and for long term or chronic use, and wherein the kit includes sodium ferrocyanide as an anticorporation and/or decorporation agent, administered to a subject in need thereof in a therapeutically effective amount up to about 350 mg. 
     
     
         2 . The kit of  claim 1  wherein a pre-exposure radioprotection composition comprises at least one of R-alpha lipoic acid, extract of  Hippophae rhamnoides,  extract of  Mentha arvensis,  N-acetyl cysteine, rose hips, vitamin E, alpha-difluoromethylornithine, aminothiols, beta carotene, bromelain,  chlorella,  CoQ10, dimethylsulfoxide, extract of  Emblica officinalis  (Gooseberry), extract of  Ganoderma lucidum,  glabridin, extract of goji berry, glutathione, extract of  Inonotus obliquus  (Chaga), extract of  Occimum santctum,  papain, famotidine, phenylbutyrate, extract of  Rosmarinus officinalis,  selenomethionine, vitamin A (retinol), vitamin C, vitamin D3, ammonium perchlorate, sodium iodate, potassium iodide, calcium citrate, magnesium citrate, phospho-soda, potassium phosphate, vitamin B12, aluminum hydroxide, vitamin D3, calcium carbonate, zinc gluconate, potassium phosphate, aluminum hydroxide, calcium alginate, magnesium citrate, and sodium ferrocyanide, and wherein the medicaments are diluted in water-based drinks or suspensions and affected tissues are cooled to as low as about 50F. 
     
     
         3 .  Claim 2  wherein the radioprotection composition effects antioxidant, DNA-protection, pro-survival benefits and anticorporation or blocking benefits against radioisotope uptake. 
     
     
         4 .  Claim 2  whereby said anticorporation may be of at least one of iodine, cobalt, strontium, phosphorus, calcium, uranium, thallium, or cesium. 
     
     
         5 . The kit of  claim 1  wherein a post-exposure radiomitigation composition comprises at least one of R-alpha lipoic acid, extract of  Hippophae rhamnoides,  extract of  Mentha arvensis,  N-acetyl cysteine, rose hips, vitamin E, beta carotene, CoQ10, dimethylsulfoxide (DMSO), extract of  Ginkgo biloba,  phenylbutyrate, selenomethionine, vitamin C, activated charcoal, ammonium perchlorate, Attapulgite, Bentonite clay, calcium alginate,  chlorella,  ethylenediaminetetraacetic acid, French Green clay, Fuller's Earth, green tea extract, Montmorillonite clay, Pascalite, psyllium husk powder, citric acid, calcium citrate, and Zeolite, sodium iodate, potassium iodide, potassium phosphate, aluminum hydroxide, ammonium perchlorate, activated charcoal,  chlorella,  phospho-soda, potassium phosphate, and sodium ferrocyanide. 
     
     
         6 .  Claim 5  wherein the radiomitigation composition effects DNA-repair, anti-RIBEs (radiation-induced bystander effects), decorporation and pro-survival benefits. 
     
     
         7 .  Claim 5  whereby decorporation ingredients may be delivered by fibrous wetted durable textured disposable towelette with optional ink tracer for external or dermal use. 
     
     
         8 . The kit of  claim 1  wherein a post-exposure radiorecovery composition comprises at least one of  Angelica sinensis, Ganoderma lucidum,  vitamin A, extract of  Inonotus obliquus  (Chaga), vitamin E, extract of goji berry, extract of  Grifola frondosa,  extract of  Hippophae rhamnoides,  vitamin C, dimethylsulfoxide, extract of  Rosmarinus officinalis,  flaxseed oil, glabridin, extract of  Hippophae rhamnoides,  phenylbutyrate, and 4-androstenedione. 
     
     
         9 .  Claim 8  wherein the radiorecovery composition effects medical benefits against acute radiation syndrome, hematopoietic damage, spleen damage, and burns, and effects anti-fibrosis and anti-inflammation and anticancer radiorecovery benefits. 
     
     
         10 . The kit of  claim 1  whereby said kit contain instructions and apparatus for administering the kit compositions, applications, dilution, and cooling.