Sleep disorder compositions and treatments thereof

Abstract

The invention relates to a pharmaceutical composition comprising a Cannabis extract and optionally one or more pharmaceutically acceptable carriers, diluents, adjuvants, excipients or any combination thereof, the Cannabis extract comprising a cannabinoid fraction comprising Δ9-Tetrahydrocannabinol (THC), Cannabidiol (CBD), and Cannabinol (CBN) and a terpene fraction in an amount of at least 3% by weight of the extract. The invention also relates to methods of treating sleep disorders using this pharmaceutical composition.

1 . A pharmaceutical composition comprising a  Cannabis  extract and optionally one or more pharmaceutically acceptable carriers, diluents, adjuvants, excipients or any combination thereof, the  Cannabis  extract comprising a cannabinoid fraction comprising Δ 9 -Tetrahydrocannabinol (THC), Cannabidiol (CBD), and Cannabinol (CBN) and a terpene fraction in an amount of at least 3% by weight of the extract. 
     
     
         2 . The pharmaceutical composition of  claim 1 , comprising THC in an amount from 5% to 90% by weight of the extract. 
     
     
         3 . The pharmaceutical composition of  claim 1 , comprising CBD in an amount from 1% to 20% by weight of the extract. 
     
     
         4 . The pharmaceutical composition of  claim 1 , comprising CBN in an amount from 1% to 20% by weight of the extract. 
     
     
         5 . The pharmaceutical composition of  claim 1 , wherein the terpene fraction comprises one or more of linalool, myrcene, and nerolidol. 
     
     
         6 . The pharmaceutical composition of  claim 1 , wherein the terpene fraction comprises beta-myrcene in an amount from 1% to 50% by weight of the terpene fraction. 
     
     
         7 . The pharmaceutical composition of  claim 1 , wherein the THC is a main cannabinoid. 
     
     
         8 . The pharmaceutical composition of  claim 1 , wherein the ratio of THC:CBN is from 5:1 to 20:1. 
     
     
         9 . The pharmaceutical composition of  claim 1 , wherein the ratio of THC:CBD is from 10:1 to 50:1. 
     
     
         10 . The pharmaceutical composition of  claim 1 , wherein the  Cannabis  extract is a  Cannabis  oil. 
     
     
         11 . The pharmaceutical composition of  claim 1 , the  Cannabis  extract comprises the terpene fraction in an amount of less than 50% by weight of the extract. 
     
     
         12 . The pharmaceutical composition of  claim 1 , wherein the ratio of the cannabinoid fraction:terpene fraction is about 8:1 to about 33:1. 
     
     
         13 . (canceled) 
     
     
         14 . A medicament comprising an effective amount of the pharmaceutical composition of  claim 1 . 
     
     
         15 . A method for treating a sleep disorder, comprising administering to a patient in need thereof an effective amount of the pharmaceutical composition of  claim 1 . 
     
     
         16 . (canceled)