Synergistic Compositions for Gynecological Procedures

Abstract

Synergistic compositions for use in treatment during gynecological procedures are provided. Synergistic compositions that enable practitioners to perform gynecological procedures without pain or bleeding to patients are provided.

What is claimed is: 
     
         1 . A synergistic combination comprising a neuroanalgesic and a prostaglandin for reducing or eliminating pain and bleeding during invasive gynecological procedures. 
     
     
         2 . The synergistic combination of  claim 1 , wherein the neuroanalgesic is fentanyl and the prostaglandin is misoprostol. 
     
     
         3 . The synergistic combination of  claim 2 , wherein a dose of the synergistic combination comprises the fentanyl in an amount ranging from about 15 μg to about 20 μg and comprises the misoprostol in an amount ranging from about 75 μg to about 175 μg. 
     
     
         4 . The synergistic combination of  claim 1 , wherein the synergistic combination further comprises a component selected from the group consisting of an analgesic, an anesthetic, a spasmolytic, a muscle relaxant, and combinations thereof. 
     
     
         5 . The synergistic combination of  claim 4 , wherein the analgesic is selected from the group consisting of acetaminophen, ibuprofen, morphine, naproxen, oxycodone, and combinations thereof. 
     
     
         6 . The synergistic combination of  claim 4 , wherein the anesthetic is selected from the group consisting of lidocaine, prilocaine, tetracaine, iontocaine, and combinations thereof. 
     
     
         7 . The synergistic combination of  claim 4 , wherein the spasmolytic is selected from the group consisting of hyoscine, carisoprodol, cyclobenzaprine, metaxalone, methocarbamol, and combinations thereof. 
     
     
         8 . The synergistic combination of  claim 4 , wherein the muscle relaxant is selected from the group consisting of thiocolchicoside, meprobamate, barbiturates, methaqualone, glutethimide, ketobemidone, piritramide. 
     
     
         9 . The synergistic combination of  claim 2 , wherein a dose of the synergistic combination comprises the misoprostol in an amount selected from the group consisting of 75 μg, 100 μg, 125 μg, 150 μg, and 175 μg. 
     
     
         10 . The synergistic combination of  claim 2 , wherein a dose of the synergistic combination comprises the fentanyl in an amount selected from the group consisting of 15 μg, 17 μg, and 20 μg. 
     
     
         11 . The synergistic combination of  claim 10 , wherein a dose of the synergistic combination comprises the misoprostol in an amount selected from the group consisting of 75 μg, 100 μg, 125 μg, 150 μg, and 175 μg. 
     
     
         12 . The synergistic combination of  claim 2 , wherein a dose of the synergistic combination comprises about 100 μg of the misoprostol and about 15 μg to about 20 μg of the fentanyl. 
     
     
         13 . The synergistic combination of  claim 2 , wherein a dose of the synergistic combination comprises about 15 μg of the fentanyl and about 75 μg to about 165 μg of the misoprostol.