Bioactive glass compositions and dentin hypersensitivity remediation

Abstract

A dental formulation including: a bioactive glass composition as defined herein, in an effective amount; and a suitable carrier as defined herein, in an effective amount. Also disclosed is a method of making and using the dental formulation to treat, for example, dentin sensitivities.

What is claimed is: 
     
         1 . A dental formulation comprising:
 a bioactive glass composition in an effective amount comprising a source of:
 2 to 70% B2O3, 
 2 to 16% Al2O3, 
 5 to 30% CaO, 
 1 to 6% P2O5, 
 1 to 20% Na2O, and 
 1 to 20% MgO, based on a 100 mol % total of the composition; and 
   a carrier, in an effective amount based on the combined weight of the bioactive glass and the carrier.   
     
     
         2 . The dental formulation of  claim 1 , wherein:
 the bioactive glass further comprises a source of from 5 to 50% SiO 2 , based on a 100 mol % total of the composition, and   the carrier comprises a source of silica of from 1 to 25 wt % SiO 2  by super addition to the bioactive glass.   
     
     
         3 . The dental formulation of  claim 1 , wherein the bioactive glass further comprises a source of from 1 to 20% K2O. 
     
     
         4 . The dental formulation of  claim 1 , wherein the bioactive glass is essentially free of silica as a source of SiO 2 , and free of inorganic potassium salts as a source of K 2 O. 
     
     
         5 . The dental formulation of  claim 1 , further comprising a source of fluoride ion in an amount of from 1 to 25 mol % by super addition to the composition. 
     
     
         6 . The dental formulation of  claim 5 , wherein the source of fluoride ion is selected from NaF, SnF2, CaF2, or a combination thereof. 
     
     
         7 . The dental formulation of  claim 1 , wherein the bioactive glass is essentially free of a source of fluoride ion. 
     
     
         8 . The dental formulation of  claim 1 , wherein the bioactive glass composition in an effective amount is from 0.1 to 10 wt %, and the suitable carrier in an effective amount is from 90 to 99.9 wt %. 
     
     
         9 . The dental formulation of  claim 1 , wherein the carrier comprises at least one of an abrasive, a humectant, a flavorant, a colorant, an antibacterial agent, a surfactant, a whitening agent, a binder, or a mixture thereof. 
     
     
         10 . The dental formulation of  claim 1 , wherein the suitable carrier comprises one or more forms selected from: a gum, a paste, a powder, a toothpaste, a mouthwash, a poultice, a tea, a sucker, a spray, or a mixture thereof. 
     
     
         11 . The dental formulation of  claim 1 , wherein the bioactive glass composition in an effective amount comprising a source of:
 6 to 10% Al2O3,   15 to 25% CaO,   1.5 to 2% P2O5,   4 to 8% Na2O,   6 to 10% K2O, and   6 to 10% MgO, based on a 100 mol % total of the composition.   
     
     
         12 . The dental formulation of  claim 1 , wherein the bioactive glass composition comprises:
 40 to 60% B2O3, and   0 to 10% SiO2, based on a 100 mol % total of the composition.   
     
     
         13 . The dental formulation of  claim 1 , wherein the bioactive glass composition comprises:
 20 to 40% B2O3, and   10 to 30% SiO2, based on a 100 mol % total of the composition.   
     
     
         14 . The dental formulation of  claim 1 , wherein the bioactive glass composition comprises:
 5 to 20% B2O3, and   30 to 50% SiO2, based on a 100 mol % total of the composition.   
     
     
         15 . A method of treating dental hypersensitivity, comprising:
 reacting a borate or borosilicate glass composition with mammalian saliva to form hydroxycarbonated apatite or fluorapatite on a dentin surface, a dentin tubule, or combination thereof.   
     
     
         16 . The method of  claim 15 , wherein the borate or borosilicate glass composition comprises:
 2 to 70% B2O3,   2 to 16% Al2O3,   5 to 30% CaO,   1 to 6% P2O5,   1 to 20% Na2O, and   1 to 20% MgO, based on a 100 mol % total of the composition.   
     
     
         17 . The method of  claim 16 , wherein the borate or borosilicate glass composition in an effective amount comprising a source of:
 6 to 10% Al2O3,   15 to 25% CaO,   1.5 to 2% P2O5,   4 to 8% Na2O,   6 to 10% K2O, and   6 to 10% MgO, based on a 100 mol % total of the composition.   
     
     
         18 . The method of  claim 16 , wherein the borate or borosilicate glass composition comprises:
 40 to 60% B2O3, and   0 to 10% SiO2, based on a 100 mol % total of the composition.   
     
     
         19 . The method of  claim 16 , wherein the borate or borosilicate glass composition comprises:
 20 to 40% B2O3, and   10 to 30% SiO2, based on a 100 mol % total of the composition.   
     
     
         20 . The method of  claim 16 , wherein the borate or borosilicate glass composition comprises:
 5 to 20% B2O3, and   30 to 50% SiO2, based on a 100 mol % total of the composition.   
     
     
         21 . The method of  claim 16 , wherein the borate or borosilicate glass composition comprises:
 a source of fluoride ion in an amount of from 1 to 25 mol % by super addition to the composition.