Systems, methods, and devices for sterilizing antiseptic solutions

Abstract

A method for sterilizing an antiseptic solution includes providing a container containing the antiseptic solution, the antiseptic solution having an initial purity, selecting a sterilization temperature from about 85° C. to about 135° C. and an sterilization time from about 1 minute to about 19 hours, heating the antiseptic solution to the selected sterilization temperature, maintaining the temperature for the selected sterilization time, and terminating the heating of the antiseptic solution when the sterilization time expires. After terminating the heating, the antiseptic solution has a post-sterilization purity. The sterilization temperature and the sterilization time are selected such that after terminating the heating, the antiseptic solution is sterile and has a post-sterilization purity of at least about 92% and the percentage point change in purity from the initial purity to the post-sterilization purity is at most about 5%.

1 . A frangible container containing an antiseptic composition,
 wherein the frangible container comprises one or more walls having a thickness of between about 0.15 and 0.45 mm,   wherein the frangible container comprises glass, and   wherein the antiseptic composition comprises an antimicrobial molecule selected from the group consisting of chlorhexidine gluconate and octenidine dihydrochloride.   
     
     
         2 . The frangible container of  claim 1 , wherein the thickness is sufficient to withstand a sterilization process for sterilizing the antiseptic composition, wherein the sterilization process comprises heating the frangible container containing the antiseptic composition to a temperature of from about 85° C. to about 135° C. 
     
     
         3 . The frangible container of  claim 1 , wherein the antimicrobial molecule comprises chlorhexidine gluconate. 
     
     
         4 . The frangible container of  claim 1 , wherein the frangible container contains between about 0.01 and 100 mL of the antiseptic composition. 
     
     
         5 . The frangible container of  claim 1 , wherein a portion of the frangible container comprises at least one non-frangible metal. 
     
     
         6 . The frangible container of  claim 1 , wherein the antiseptic composition is a solution comprising a solvent selected from the group consisting of alcohols, water, and combinations thereof. 
     
     
         7 . The frangible container of  claim 6 , wherein the solvent comprises an alcohol selected from the group consisting of ethanol, isopropanol, n-propanol, and combinations thereof. 
     
     
         8 . The frangible container of  claim 7 , wherein the solvent further comprises water. 
     
     
         9 . The frangible container of  claim 1 , wherein the antiseptic composition is a gel. 
     
     
         10 . The frangible container of  claim 1 , wherein the antiseptic composition is sterile.