Gastroretentive formulations

Abstract

The present invention relates to gastroretentive formulations and to processes for preparation of the same. Particularly, the invention relates to gastroretentive dosage forms comprising at least one swelling agent and at least one swelling retardant.

We claim: 
     
         1 ) A gastroretentive formulation comprising at least one active agent, at least one swelling agent and at least one swelling retardant. 
     
     
         2 ) The formulation of  claim 1  wherein the active agent is an anti-diabetic agent, a cardiovascular agent, a neurological agent, an anti-parkinson's disease agent, an anti-infective agent, an analgesic, an anti-inflammatory agent, an anti-arthritic, an anti-hyperlipidemic agents, or an anti-hypertensive or any combinations thereof. 
     
     
         3 ) The formulation of  claim 1  wherein the active agent is carbidopa, levodopa or combination thereof. 
     
     
         4 ) The formulation of  claim 1  wherein the active agent is valsartan, hydrochlorthiazide or combination thereof. 
     
     
         5 ) The formulation of  claim 1  wherein the swelling agent is polyethylene oxide. 
     
     
         6 ) The formulation of  claim 1  wherein the swelling retardant is ethyl cellulose. 
     
     
         7 ) The formulation of  claim 1  wherein the formulation is in the form of a monolithic dosage form. 
     
     
         8 ) The formulation of  claim 1  wherein the formulation is in the form of a multi-layered dosage form. 
     
     
         9 ) The formulation of  claim 8  wherein the formulation is a bi-layered formulation comprising active layer and gastroretentive layer. 
     
     
         10 ) The formulation of  claim 9  wherein the gastroretnetive layer comprises at least one swelling agent and at least one swelling retardant.