Pyridyl benzothiophenes as kinase inhibitors

Abstract

This invention is directed to compounds, which are useful as protein kinase (PK) inhibitors and can be used to treat such diseases as cancer, blood vessel proliferative disorders, fibrotic disorders, mesangial cell proliferative disorders, metabolic diseases inflammatory disorders and neurodegenerative disorders.

What is claimed is: 
     
         1 . A compound represented by Formula I or a pharmaceutically acceptable salt thereof or stereoisomeric forms thereof, or the enantiomers, diastereoisomers, and pharmaceutically acceptable salts thereof: 
       
         
           
           
               
               
           
         
       
       wherein:
 W is S; 
 R 1  is hydrogen; 
 R 2  is hydrogen; 
 R 3  is hydrogen; 
 X is —C(O)N(R 4 R 5 ); 
 R 4  is hydrogen; 
 R 5  is substituted heterocycle or substituted alkyl; 
 Y is hydrogen; 
 Z is —NHR 11 ; and 
 R 11  is hydrogen. 
 
     
     
         2 . The compound of  claim 1 , wherein R 5  is substituted aromatic heterocycle or substituted alkyl. 
     
     
         3 . The compound of  claim 1 , wherein R 5  is an aromatic heterocycle substituted with —C 1-8  alkyl group or R 5  is an alkyl group substituted with a methylphenyl group. 
     
     
         4 . The compound of  claim 3 , wherein the —C 1-8  alkyl group is tert-butyl. 
     
     
         5 . The compound of  claim 1 , wherein the compound is selected from the group consisting of 
       
         
           
           
               
               
           
         
       
       and pharmaceutically salts thereof. 
     
     
         6 . A pharmaceutical composition comprising as active ingredient a therapeutically effective amount of a compound according to  claim 1  and a pharmaceutically acceptable adjuvant, diluent or carrier.