Antiseptic, antiseborrheic and exfoliating composition to remove or prevent acne

Abstract

The invention refers to an antimicrobial, exfoliating and seboregulating hydrosoluble composition comprising a combination of diallyl disulphide modified oxide (DDMO) and alpha hydroxyethanoic acid (glycolic acid), which acts removing bacteria affecting the skin including those caused by acne, said composition also provides deep cleansing, exfoliating action, reduces epidermal cohesion facilitating cellular change, preventing the occurrence of several forms of acne in the skin and additionally producing seboregulating effects by avoiding blockage of sebaceous glands.

1 - 9 . (canceled) 
     
     
         10 . A method for killing or preventing the growth of microorganisms on the skin of a subject, the method comprising administering a pharmaceutical composition to skin of the subject, wherein the composition comprises from 0.001 to 10% by weight of diallyl disulfide modified oxide, from 1 to 12% by weight of glycolic acid, from 0.3 to 24% by weight of one or more surfactants, from 0.3 to 10% by weight of a moisturizing agent, from 0.2 to 10% by weight of an aromatizing agent, and from 40 to 70% by weight of an aqueous solvent. 
     
     
         11 . The method according to  claim 10 , wherein the one or more surfactants are selected from the group consisting of linear alkylbenzensulfonates and ionic alkyl sulfates. 
     
     
         12 . The method according to  claim 10 , wherein the one or more surfactants are selected from the group consisting of sodium lauryl sulfate, sodium lauryl ether sulfate, and ammonium lauryl sulfate. 
     
     
         13 . The method according to  claim 10 , wherein the moisturizing agent is selected from the group consisting of ethylene glycol, propylene glycol, glycerin, sorbitol, low molecular weight polyethylenes, polyoxyethylated glycerols, and polyoxyethylated sugars. 
     
     
         14 . The method according to  claim 10 , wherein the aqueous solvent is selected from water and water-hydrosoluble alcohol mixtures. 
     
     
         15 . The method of  claim 10 , wherein the microorganism is a gram-negative bacteria or gram-positive bacteria. 
     
     
         16 . The method of  claim 10 , wherein the microorganism is  Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae, Proteus vulgaris, Staphylococcus aureus, Staphylococcus epidermidis, Propionibacterium acnes,  or a combination thereof. 
     
     
         17 . The method of  claim 10 , wherein the microorganism is a fungus. 
     
     
         18 . The method of  claim 17 , wherein the fungus is  Candida albicans.    
     
     
         19 . A method for killing or preventing the growth of microorganisms on the skin of a subject, the method comprising administering a pharmaceutical composition to skin of the subject, wherein the composition comprises:
 a) diallyl disulfide modified oxide;   b) glycolic acid;   c) a surfactant selected from the group consisting of (i) sodium lauryl sulfate, (ii) sodium lauryl ether sulfate, and (iii) sodium lauryl sulfate and sodium lauryl ether sulfate;   and   d) a moisturizing agent selected from the group consisting of glycerin, ethylene glycol, and sorbitol.   
     
     
         20 . The method of  claim 19 , wherein the diallyl disulfide modified oxide is 0.8% or 1.0% by weight of the composition. 
     
     
         21 . The method of  claim 19 , wherein the moisturizing agent is glycerin. 
     
     
         22 . The method of  claim 19 , wherein the surfactant is 20% by weight of the composition. 
     
     
         23 . The method of  claim 19 , wherein the moisturizing agent is 0.4% or 0.5% by weight of the composition. 
     
     
         24 . The method of  claim 19 , wherein the glycolic acid is 11.42% by weight or 11.6% by weight of the composition. 
     
     
         25 . A method for removing grease or oil from the skin of a subject, the method comprising administering a pharmaceutical composition to skin of the subject, wherein the composition comprises from 0.001 to 10% by weight of diallyl disulfide modified oxide, from 1 to 12% by weight of glycolic acid, from 0.3 to 24% by weight of one or more surfactants, from 0.3 to 10% by weight of a moisturizing agent, from 0.2 to 10% by weight of an aromatizing agent, and from 40 to 70% by weight of an aqueous solvent. 
     
     
         26 . The method of  claim 25 , wherein the method prevents obstruction of pores. 
     
     
         27 . The method of  claim 25 , wherein the method removes comedonal block. 
     
     
         28 . The method of  claim 25 , wherein the method avoids formation of new blackheads and pustules. 
     
     
         29 . A method for removing grease or oil from the skin of a subject, the method comprising administering a pharmaceutical composition to skin of the subject, wherein the composition comprises:
 a) diallyl disulfide modified oxide;   b) glycolic acid;   c) a surfactant selected from the group consisting of (i) sodium lauryl sulfate, (ii) sodium lauryl ether sulfate, and (iii) sodium lauryl sulfate and sodium lauryl ether sulfate;   and   d) a moisturizing agent selected from the group consisting of glycerin, ethylene glycol, and sorbitol.