Method for preventing and/or treating aging-associated cognitive impairment and neuroinflammation

Abstract

The present invention is directed to a method for preventing and/or treating aging-related cognitive impairment in the central nervous system. The method comprises administering to a subject in need thereof a Ppargc1a activator 2-(4-tert-butylphenyl)-1H-benzimidazole, 2-[4-(1,1-dimethylethyl)phenyl]-1H-benzimidazole, in an effective amount. A preferred route of administration is oral administration.

1 . A method of suppressing neuroinflammation or systemic inflammation and metabolic abnormalities of microglia in the brain comprising the step of:
 administering to a subject in need thereof an effective mount of a compound 2-[4-(1,1-dimethylethyl)phenyl]-1H-benzimidazole, or a pharmaceutically acceptable salt thereof.   
     
     
         2 . The method according to  claim 1 , wherein said method reverses or alleviates cognitive behavioral dysfunction of the subject. 
     
     
         3 . The method according to  claim 1 , wherein said method suppresses neuroinflammation and/or systemic inflammation of the subject. 
     
     
         4 . The method according to  claim 1 , wherein said method suppresses metabolic abnormalities of microglia in the brain of the subject. 
     
     
         5 . The method according to  claim 1 , wherein said compound is administered by systemic administration. 
     
     
         6 . The method according to  claim 1 , wherein said compound is administered by oral administration.