Catheter with omni-directional optical tip having isolated optical paths

Abstract

A catheter enables real-time light measurements, for example, without limitation, diffuse reflectance, fluorescence, etc., from biological materials, such as tissue (including blood), while performing RF ablation. The catheter tip design isolates illumination and collection paths within the tip electrode such that light for illuminating the tissue of interest (e.g., cardiac tissue or blood) is isolated within the tip electrode from light that returns from the tissue to the catheter tip, and vice versa. Such a design advantageously avoids saturation of the optical detector, and ensures diffusion of the illumination light within the medium of interest. The catheter has a catheter body and a tip electrode with a shell wall and a hollow cavity. The shell wall has at least an illumination opening and a collection opening. The catheter further includes a first fiber optic cable in communication with the illumination opening, and a second fiber optic cable in communication with the hollow cavity, wherein light emitted from the first fiber optic cable exits the tip electrode to reach tissue through the illumination opening in defining a first path and returns to the tip electrode from the tissue into the hollow cavity through the collection opening in defining a second path, the first and second paths being optically isolated from each other within the tip electrode. The invention also includes a method of making an ablation electrode tip defining isolated optical paths with in the tip electrode for light exiting the tip electrode and light returning to the tip electrode.

We claim: 
     
         1 . A catheter, comprising:
 a catheter body;   a tip electrode distal the catheter body, the tip electrode having a shell wall, a hollow cavity and a plug, the shell wall having at least an illumination opening and a collection opening, and the plug sealing the hollow cavity at a proximal end of the shell wall;   a first fiber optic cable in communication with the illumination opening and optically isolated from the hollow cavity;   a second fiber optic cable in communication with the hollow cavity and optically isolated from the first fiber optic cable; and   an irrigation tubing configured to deliver irrigation fluid to the hollow cavity;   wherein the first and second fiber optic cables and the irrigation tubing extend in passages in the plug.   
     
     
         2 . The catheter of  claim 1 , wherein the irrigation tubing is anchored in its passage in the plug. 
     
     
         3 . The catheter of  claim 1 , wherein the first fiber optic cable extends through the hollow cavity. 
     
     
         4 . The catheter of  claim 3 , wherein the first fiber optic cable is optically isolated by a coating of reflective buffer material thereon. 
     
     
         5 . The catheter of  claim 1 , wherein the illumination opening has a semi-spherical cross section. 
     
     
         6 . The catheter of  claim 1 , wherein the illumination opening is filled with an optically scattering material. 
     
     
         7 . The catheter of  claim 1 , wherein the shell has a longitudinal axis and first, second and third sections, the first section being generally perpendicular to the longitudinal axis, the second section being generally at an angle between about zero and 90 degrees to the longitudinal axis, and the third section being generally parallel to the longitudinal axis. 
     
     
         8 . The catheter of  claim 7 , wherein the first section has the collection opening and the second section has the illumination opening and the third section has another collection opening. 
     
     
         9 . The catheter of  claim 7 , wherein the first section is distal of the second section which is distal of the third section. 
     
     
         10 . The catheter of  claim 7 , wherein the first section has the collection opening, and the second section has the illumination opening. 
     
     
         11 . The catheter of  claim 7 , wherein the second section has multiple illumination openings, and the third section has multiple collection openings, and wherein the openings within each section are equi-angular from each other about the longitudinal axis. 
     
     
         12 . The catheter of  claim 7 , wherein the angle of the second section is about 45 degrees. 
     
     
         13 . The catheter of  claim 7 , wherein the angle of the second section is about 30 to about 60 degrees. 
     
     
         14 . The catheter of  claim 1 , wherein the hollow cavity includes a distal dome cavity. 
     
     
         15 . The catheter of  claim 1 , wherein the first and second fiber optic cables are fixed to the plug within their respective passages. 
     
     
         16 . The catheter of  claim 1 , wherein the tip electrode is adapted for RF ablation. 
     
     
         17 . The catheter of  claim 16 , further comprising an electrode lead wire attached at its distal end within a blind hole in the plug. 
     
     
         18 . The catheter of  claim 1 , further comprising a deflectable intermediate section between the catheter body and the tip electrode. 
     
     
         19 . The catheter of  claim 1 , further comprising a temperature sensor. 
     
     
         20 . The catheter of  claim 19 , wherein the temperature sensor is located within a blind hole in the plug. 
     
     
         21 . The catheter of  claim 1 , further comprising a location sensor. 
     
     
         22 . A catheter according to  claim 21 , wherein the location sensor is located within a blind hole in the plug. 
     
     
         23 . A catheter, comprising: a catheter body;
 a tip electrode distal the catheter body, the tip electrode having a shell wall, a hollow cavity and a plug, the shell wall having illumination openings and collection openings, and the plug sealing the hollow cavity at a proximal end of the shell wall;   at least one emitting fiber optic cable in communication with at least one of the illumination openings, the at least one emitting fiber optic cable being optically isolated from the hollow cavity;   at least one receiving fiber optic cable in communication with the hollow cavity and optically isolated from the at least one emitting fiber optic cable;   and an irrigation tubing configured to deliver irrigation fluid to the hollow cavity;   wherein the at least one emitting fiber optic cable, the at least one receiving fiber optic cable, and the irrigation tubing extend in passages in the plug.   
     
     
         24 . The catheter of  claim 23 , wherein a distal end of the at least one emitting fiber optic cable extends substantially into the at least one of the illumination openings. 
     
     
         25 . The catheter of  claim 23 , wherein the at least one receiving fiber optic cable is configured to receive light in the hollow cavity. 
     
     
         26 . The catheter of  claim 23 , wherein at least one of the collection openings is at a distal end of the tip electrode along a longitudinal axis of the tip electrode. 
     
     
         27 . The catheter of  claim 23 , wherein the at least one emitting fiber optic cable comprises a respective emitting fiber optic cable for each of the illumination openings. 
     
     
         28 . The catheter of  claim 23 , wherein the tip electrode is configured with at least four collection openings and three illumination openings. 
     
     
         29 . The catheter of  claim 23 , wherein the irrigation tubing is anchored in its passage in the plug. 
     
     
         30 . The catheter of  claim 23 , wherein the at least one emitting fiber optic cable extends through the hollow cavity and is optically isolated from the hollow cavity. 
     
     
         31 . The catheter of  claim 30 , wherein the at least one emitting fiber optic cable is optically isolated by a coating of reflective buffer material thereon. 
     
     
         32 . The catheter of  claim 23 , wherein the shell has a longitudinal axis and first, second and third sections, the first section being generally perpendicular to the longitudinal axis, the second section being generally at an angle between about zero and 90 degrees to the longitudinal axis, and the third section being generally parallel to the longitudinal axis. 
     
     
         33 . The catheter of  claim 32 , wherein the first section and the third section have the collection openings and the second section has the illumination openings. 
     
     
         34 . The catheter of  claim 23 , further comprising a deflectable intermediate section between the catheter body and the tip electrode. 
     
     
         35 . The catheter of  claim 23 , wherein the tip electrode is configured for ablation, and the catheter further comprises an electrode lead wire attached at its distal end within a blind hole in the plug.