Therapeutic systems, devices, and compositions with wound healing and tissue regenerative properties, uses thereof, and corresponding methods

Abstract

Presented herein are compositions that can be administered to a subject having damaged tissue, for example a wound. The compositions are often administered in combination with administration of energy (e.g., laser energy, light from a light emitting diode, radiofrequency (RF) energy, audio frequency energy, etc.) from an energy generating device and/or system to the affected site. The compositions, systems, devices, and methods herein were found to induce wound healing and tissue regeneration.

We claim: 
     
         1 . A composition with wound healing and tissue regenerative properties, the composition comprising two or more of, or three or more of:
 a. collagen   b. hyaluronic acid   c. fucose,   d. copper, and   e. iron.   
     
     
         2 . The composition of  claim 1 , wherein the collagen comprises collagen fibers. 
     
     
         3 . The composition of  claim 1 , wherein the collagen comprises partially or completely hydrolyzed collagen. 
     
     
         4 . The composition of any one of  claim 1 , wherein the collagen is acid treated collagen. 
     
     
         5 . The composition of any one of  claim 1 , wherein the copper comprises a copper salt. 
     
     
         6 . The composition of  claim 5 , wherein the copper salt comprises CuCl 2  or CuCl 3 . 
     
     
         7 . The composition of any one of  claim 1 , wherein the iron comprises an iron salt. 
     
     
         8 . The composition of  claim 7 , wherein the iron salt comprises FeCl 3 . 
     
     
         9 . The composition of any one of  claim 1 , wherein the composition has a pH in a range of 1 to 4, or 2 to 3. 
     
     
         10 . The composition of any one of  claim 1 , wherein the composition comprises a water content in a range of 0% to 20%, or 0% to 10%, or 0% to 5% (wt/wt). 
     
     
         11 . A system configured to be used to treat and/or generate tissue, the system comprising:
 a device configured to generate one or more types of therapeutic energy for provision to the tissue, the one or more types of therapeutic energy comprising one or more of laser radiation, radio frequency (RF) waves, audio frequency waves, or light from a light emitting diode (LED); and   a composition with wound healing and/or tissue regenerative properties, the composition comprising two or more of, or three or more of:   a. collagen   b. hyaluronic acid   c. fucose,   d. copper, and   e. iron.   
     
     
         12 . The system of  claim 11 , wherein the collagen is present in the composition in a range of 0.01-0.5% (wt/wt), the hyaluronic acid is present in the composition in a range of 0.1-1.5% (wt/wt), the copper is present in the composition in a range of 0.01%-0.1% (wt/wt) and the iron is present in the composition in a range of 0.01%-0.1% (wt/wt). 
     
     
         13 . The system of  claim 11 , wherein the device comprises a laser configured to generate the laser radiation, the laser comprising one or more individual fibers configured to conduct the laser radiation, the laser radiation having a power of about 0.1-5 W per fiber. 
     
     
         14 . The system of  claim 11 , wherein the device comprises an LED configured to generate light comprising photons configured to be received by the tissue, the LED arranged on a board with a plurality of other LEDs configured to generate the same and/or similar light. 
     
     
         15 . The system of  claim 11 , wherein the device comprises an RF and/or an audio frequency function generator, the RF and/or audio frequency comprising a frequency of about 100 Hz-4 MHz. 
     
     
         16 . A device for imaging tissue, comprising:
 one or more light emitting diodes (LED) configured to emit light for illuminating the tissue, the light have a wavelength of about 790-860 nm (IR), and a power of about 0.5-10 W per LED, and   a camera configured to obtain images of the illuminated tissue;   wherein the one or more LEDs and the camera are configured to be moved back and forth over the tissue such that the camera acquires a plurality of images during the movement.   
     
     
         17 . The device of  claim 16 , wherein the one or more LEDs are configured to emit light in the green wavelength range of the visible spectrum or the infrared wavelength range. 
     
     
         18 . The device of  claim 16 , further comprising one or more processors configured to analyze images obtained by the camera by combining individual images into a common image, and identifying anatomical features in the tissue based on the common image. 
     
     
         19 . The device of  claim 16 , further comprising a handle or a stand coupled to the one or more LEDs and the camera, the handle or the stand configured to be manipulated by a user such that the light from the one or more LEDs is directed at the tissue. 
     
     
         20 . The device of  claim 18 , wherein the one or more processors are formed by a raspberry pi computing module.