Optimizing Mifepristone Absorption

Abstract

The present invention provides a method for altering the pharmacokinetics of mifepristone upon oral administration. Mifepristone absorption into the blood is increased upon administration with meals. The method of the invention can benefit patients suffering from conditions including psychiatric illnesses and hormonal disorders.

What is claimed is: 
     
         1 . A method of improving absorption of mifepristone in a patient suffering from Cushing's Syndrome, comprising administering to the patient for at least 7 days an oral dose of mifepristone of 900 mg per day within about 30 minutes after consuming a meal, such that the pharmacokinetics of mifepristone absorption are altered by increasing the maximum plasma concentration (C max ) and increasing the area under the curve (AUC) as compared to the C max  and AUC that would result from administering mifepristone without food in the fasted state in the absence of the meal, said increase in AUC being at least 44%, and thereby improving mifepristone absorption in the patient. 
     
     
         2 . The method of  claim 1 , wherein the patient suffers from Cushing's disease. 
     
     
         3 . The method of  claim 1 , wherein the daily oral dose of mifepristone is administered for at least 28 days. 
     
     
         4 . The method of  claim 1 , wherein the mifepristone is administered as a single dose. 
     
     
         5 . The method of  claim 1 , wherein the increase in AUC is at least 65%. 
     
     
         6 . The method of  claim 1 , wherein the increase in C max  is at least 34%. 
     
     
         7 . The method of  claim 1 , wherein the increase in C max  is at least 56%. 
     
     
         8 . The method of  claim 5 , wherein the increase in C max  is at least 34%. 
     
     
         9 . The method of  claim 5 , wherein the increase in C max  is at least 56%. 
     
     
         10 . The method of  claim 1 , wherein the patient is a male. 
     
     
         11 . The method of  claim 1 , wherein the patient is a female.