Food or feed composition for improving cognitive function or memory comprising extract of desalted salicornia europaea

Abstract

The present invention relates to a pharmaceutical composition comprising an acanthoside B compound as an effective ingredient for preventing or treating dementia or for improving a cognitive function. In the present invention, a desalted glasswort extract, and acanthoside B, which is isolated from the extract and acts as an effective ingredient inhibitory of acetylcholine esterase, were found to have an excellent neuroprotective activity through the inhibition of neuroinflammation and to improve memory retention and remarkably enhance spatial cognitive ability as measured by passive avoidance test and Y-maze test in a scopolamine-induced amnesic animal model. The acanthoside B or glasswort extract of the present invention can be applied to a pharmaceutical composition for preventing or treating dementia, a pharmaceutical composition for improving a cognitive function, or a health functional food or feed for improving memory retention and cognitive function.

1 - 10 . (canceled) 
     
     
         11 . A method for the treatment of dementia comprising the step of:
 administering, to a subject, a composition comprising a desalted  Salicornia  spp. extract, wherein the desalted  Salicornia  spp. extract comprises acanthoside B represented by chemical formula 1 below.   
       
         
           
           
               
               
           
         
       
     
     
         12 . The method of  claim 11 , wherein the dementia is Alzheimer-type dementia, cerebrovascular dementia, neuroinflammatory dementia, dementia with Lewy bodies (DLB), multi-infarct dementia (MID), frontotemporal lobar degeneration (FTLD), Pick's disease, corticobasal degeneration (CBD), progressive supranuclear palsy (PSP), Parkinson's disease, or Huntington's disease. 
     
     
         13 . The method of  claim 11 , wherein the desalted  Salicornia  spp. extract is obtained by subjecting desalted  Salicornia  spp. to extraction using water or 50-100 (v/v) % of a C1 to C4 lower alcohol. 
     
     
         14 . The method of  claim 11 , wherein the desalted  Salicornia  spp. extract obtained by subjecting a desalted  Salicornia  spp. enzymatic hydrolysate to extraction using water or 50-100 (v/v) % of a C1 to C4 lower alcohol. 
     
     
         15 . A method for improvement or amelioration of cognitive ability or memory, comprising the step of:
 administering, to a subject, a composition comprising a desalted  Salicornia  spp. extract, wherein the desalted  Salicornia  spp. extract comprises acanthoside B represented by chemical formula 1 below.   
       
         
           
           
               
               
           
         
       
     
     
         16 . The method of  claim 15 , wherein the desalted  Salicornia  spp. extract is obtained by subjecting desalted  Salicornia  spp. to extraction using water or 50-100 (v/v) % of a C1 to C4 lower alcohol. 
     
     
         17 . The method of  claim 15 , wherein the desalted  Salicornia  spp. extract is obtained by subjecting a desalted  Salicornia  spp. enzymatic hydrolysate to extraction using water or 50-100 (v/v) % of a C1 to C4 lower alcohol.