US2021038725A1PendingUtilityA1

Statin-containing nanoparticle preparation for enhancing function of stem cells for treating inflammatory disease, and functionally enhanced stem cells containing same for treating inflammatory disease

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Assignee: EDUCATIONAL FOUNDATION OF OSAKA MEDICAL AND PHARMACEUTICAL UNIVPriority: May 6, 2016Filed: Oct 21, 2020Published: Feb 11, 2021
Est. expiryMay 6, 2036(~9.8 yrs left)· nominal 20-yr term from priority
Inventors:Masaaki IiYasuhiko Tabata
A61K 9/0014A61K 9/0019A61K 45/00A61K 9/5153B82Y 5/00A61K 35/28A61K 9/51A61P 29/00A61K 9/5068A61K 31/366A61K 47/34C08L 67/04C08L 2203/02
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Claims

Abstract

A statin-encapsulated nanoparticle contains a bioabsorbable polymer and statin encapsulated in the nanoparticle. Suitable bioabsorbable polymers include a polylactic acid (PLA) polymer or a polylactic acid-glycolic acid (PLGA) copolymer. The statin-encapsulated nanoparticle can be used to enhance the function of a stem cell. The stem cell can be a stem cell for treating an inflammatory disease.

Claims

exact text as granted — not AI-modified
What is claimed is: 
     
         1 . A method for treating an inflammatory disease in a subject in need thereof, comprising administering a functionally enhanced stem cell or a cell preparation comprising the functionally enhanced adipose-derived stem cell the subject,
 wherein the functionally-enhanced adipose-derived stem cell comprises a statin-included nanoparticle comprising:
 a nanoparticle containing a bioabsorbable polymer; and 
 a statin included in the nanoparticle, and 
   wherein the statin-included nanoparticle is internalized within the adipose-derived stem cell.

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