Antibodies against phosphorylcholine in combination therapy with biologic agents

Abstract

Antibodies against PC, PC conjugate or bioactive components and/or fragments thereof for use in combination therapy with one or more biologic agents and/or stem cells are disclosed, as well as compositions comprising the antibodies in combination with one or more biologic agents and/or stem cells. Also disclosed are PC conjugates, PC or bioactive components and/or parts/fragments thereof for use in activation immunotherapy prior to or in combination with treatment with biologic agents and/or stem cells for curing, treating, preventing, and/or reducing the risk of developing auto-immune diseases, chronic inflammatory diseases, and cancer diseases, as well as compositions comprising them in combination with biologic agents and/or stem cells.

1 . A method for increasing the efficacy of rituximab in a non-responder mammal to rituximab for curing, treating, preventing, and/or reducing the risk of developing rheumatoid arthritis, said method comprising:
 identifying an individual that is a non-responder to rituximab; and   administering rituximab in combination with antibodies or derivatives thereof against PC or PC conjugate thereof to the non-responder,   wherein said antibodies or derivatives thereof against PC or PC conjugate is selected from the group comprising a monoclonal, polyclonal or chimeric antibody of isotype IgA, IgD, IgE, IgG, IgM, optionally in combination with any suitable excipients or adjuvants; and   wherein said mammal is selected from the group comprising rabbits, dogs, cats, horses and humans.   
     
     
         2 . The method of  claim 1 , wherein administering the rituximab comprises co-administering rituximab simultaneously with the antibodies or derivatives thereof against PC or PC conjugate thereof.