US2021032345A1PendingUtilityA1

Anti-pd-l1 antibodies, compositions and articles of manufacture

73
Assignee: GENENTECH INCPriority: Dec 9, 2008Filed: Apr 21, 2020Published: Feb 4, 2021
Est. expiryDec 9, 2028(~2.4 yrs left)· nominal 20-yr term from priority
Inventors:Bryan IrvingHenry ChiuHeather MaeckerSanjeev MariathasanSophie M. LeharYan WuJeanne Cheung
C07K 16/1145A61K 39/00C07K 2317/73C07K 16/2827A61P 35/00A61K 2039/505C07K 2317/92C07K 2317/76A61P 31/04A61P 31/10A61K 2039/507C07K 16/22C07K 16/30A61K 39/3955C07K 2317/74C07K 2317/565A61P 37/02C07K 2317/56A61K 39/39558A61P 37/04C07K 2317/71C07K 16/3046C07K 2317/24A61P 31/00C07K 16/28C07K 2317/52Y02A50/30A61P 43/00A61K 45/06A61P 33/02A61K 31/7068A61P 31/12C07K 2317/567A61P 37/00A61P 33/00C07K 2317/14C07K 16/1063A61K 2300/00
73
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Claims

Abstract

The present application relates to anti-PD-L1 antibodies, nucleic acid encoding the same, therapeutic compositions thereof, and their use enhance T-cell function to upregulate cell-mediated immune responses and for the treatment of T cell dysfunctional disorders, including infection (e.g., acute and chronic) and tumor immunity.

Claims

exact text as granted — not AI-modified
1 . An isolated heavy chain variable region polypeptide comprising an HVR-H1, HVR-H2 and HVR-H3 sequence, wherein: 
       
         
           
                 
                 
               
                     
                   (a) the HVR-H1 sequence is 
                 
                     
                   (SEQ ID NO: 1) 
                 
                     
                   GFTFSX,SWIH; 
                 
                     
                     
                 
                     
                   (b) the HVR-H2 sequence is 
                 
                     
                   (SEQ NO: 2) 
                 
                     
                   AWIX 2 PYGGSX 3 YYADSVKG; 
                 
                     
                     
                 
                     
                   (c) the HVR-H3 sequence is 
                 
                     
                   (SEQ ID NO: 3) 
                 
                     
                   RHWPGGFDY 
                 
             
                
                
                
                
                
                
                
                
                
                
                
               
            
           
         
         further wherein: X 1  is D or G; X 2  is S or L; X 3  is T or S. 
       
     
     
         2 - 95 . (canceled)

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