Multi-layer oral thin film

Abstract

Described are: a multi-layer oral thin film, comprising at least two layers arranged one on top of the other, which each comprise at least one water-soluble polymer, these at least two layers being connected to one another by at least one sealing, characterised in that the at least one sealing is not provided over the entire surface; a method for producing same; and use thereof as a medicament.

1 . A multi-layer oral thin filmy comprising at least two layers arranged one on top of the other, wherein each layer comprises at least one water-soluble polymer, the at least two layers being connected to one another by at least one sealing, wherein the at least one sealing is not provided over an entire surface. 
     
     
         2 . The multi-layer oral thin film according to  claim 1 , wherein the at least one sealing is applied in such a way that at least one overlapping edge of the at least two layers arranged one on top of the other is not closed by a sealing. 
     
     
         3 . The multi-layer oral thin film according to  claim 1 , wherein the at least one water-soluble polymer comprises a heat-sealable polymer. 
     
     
         4 . The multi-layer oral thin film according to  claim 3 , wherein the at least one sealing not provided over the entire surface comprises a heat sealing not provided over the entire surface. 
     
     
         5 . The multi-layer oral thin film according to  claim 1 , wherein the at least one water-soluble polymer comprises polyvinyl alcohol, pullulan, polyethylene oxide, polyethylene glycol and/or copolymers thereof. 
     
     
         6 . The multi-layer oral thin film according to  claim 1 , wherein at least one layer of the multi-layer oral thin film comprises at least one pharmaceutical active ingredient. 
     
     
         7 . The multi-layer oral thin film according to  claim 1 , wherein the at least two layers are connected to one another by precisely one sealing not provided over the entire surface. 
     
     
         8 . The multi-layer oral thin film according to  claim 1 , wherein the at least two layers are connected to one another by two sealings not provided over the entire surface. 
     
     
         9 . The multi-layer oral thin film according to  claim 1 , wherein the at least one sealing covers no more than 66% of the total area of a surface of the multi-layer oral thin film. 
     
     
         10 . A method for producing a multi-layer oral thin film , comprising the steps of
 a) providing a first layer comprising at least one water-soluble polymer;   b) providing a further layer comprising at least one water-soluble polymer;   c) arranging the first layer on the further layer; and   d) performing at least one sealing, which is not provided over the entire surface, in order to connect the first layer and the further layer to one another.   
     
     
         11 . The method for producing a multi-layer oral thin film according to  claim 10 , wherein at least one of the layers provided in step a) and/or step b) additionally comprises at least one pharmaceutical active ingredient. 
     
     
         12 . The method for producing a multi-layer oral thin film according to  claim 10 , wherein the at least one sealing performed in step d), not provided over the entire surface, is a heat-sealing not provided over the entire surface. 
     
     
         13 . A multi-layer oral thin film obtained by the method of  claim 10 . 
     
     
         14 . A method of administering a medicament comprised of he multi-layer oral thin film  claim 1 , the method comprising oral administration.