Composition for enhanced absorption of supplements

Abstract

A composition that includes at least one target supplement and at least one rehydration formulation is described. When the at least one target supplement is ingested as part of the composition, the bioavailability of at least one target supplement is enhanced as compared to when it is ingested separate from the composition. The at least one target supplement is absorbed more quickly and in a greater amount when it is ingested as part of the composition than when it is ingested separate from the composition. The composition also hydrates a subject more quickly.

What is claimed is: 
     
         1 . A composition comprising:
 at least one target supplement having a first absorption rate when ingested separately from the composition; and   at least one rehydration formulation, wherein, when the at least one target supplement is ingested as part of the composition, the at least one target supplement has a second absorption rate measured after ingestion that is greater than the first absorption rate.   
     
     
         2 . The composition of  claim 1 , wherein the at least one hydration formulation comprises sodium, chloride, glucose-containing saccharide, potassium, and citrate. 
     
     
         3 . The composition of  claim 2 , wherein the glucose osmolarity is greater than the sodium osmolarity in the composition 
     
     
         4 . The composition of  claim 2 , wherein the osmolarity of sodium in the composition is at least 50 mmol/L, and wherein the osmolarity of the glucose is at least 50 mmol/L. 
     
     
         5 . The composition of  claim 1 , wherein the at least one target supplement comprises at least one of melatonin, L-theanine, valerian root, 5-hydroxytryptophan, or passionflower. 
     
     
         6 . The composition of  claim 1 , wherein the at least one rehydration formulation includes at least:
 about 9.0 to about 12.6 grams of glucose per liter solvent;   about 12.9 to about 14.8 grams of sucrose per liter solvent;   about 2.0 to about 2.3 grams of sodium chloride per liter solvent;   about 0.98 to about 1.5 grams of sodium citrate per liter solvent;   about 1.4 to about 1.6 grams of potassium citrate per liter solvent; and   about 0.50 to about 0.65 grams of dipotassium phosphate per liter solvent.   
     
     
         7 . The composition of  claim 1 , wherein the at least one rehydration formulation includes at least:
 about 9.0 to about 10.8 grams of glucose per liter solvent;   about 12.6 to about 15.7 grams of sucrose per liter solvent;   about 2.0 to about 2.5 grams of sodium chloride per liter solvent;   about 0.68 to about 1.3 grams of sodium citrate per liter solvent;   about 1.4 to about 1.6 grams of potassium citrate per liter solvent; and   about 0.50 to about 0.65 grams of dipotassium phosphate per liter solvent.   
     
     
         8 . The composition of  claim 1 , wherein the at least one rehydration formulation includes at least:
 about 14.0 to about 15.6 grams of dextrose per liter solvent;   about 2.1 to about 2.5 grams of sodium chloride per liter solvent;   about 2.30 to about 2.76 grams of sodium citrate per liter solvent; and   about 1.28 to about 1.88 grams of potassium chloride per liter solvent.   
     
     
         9 . The composition of  claim 1 , wherein the composition has a total osmolarity of about 200 mmol/L to about 310 mmol/L. 
     
     
         10 . The composition of  claim 1 , wherein the composition has a total osmolarity of about 255 mmol/L to about 275 mmol/L. 
     
     
         11 . A method of orally delivering a target supplement to a subject in need thereof, comprising administering to the subject the composition of  claim 1 . 
     
     
         12 . The method of  claim 11 , wherein the at least one rehydration formulation includes at least:
 about 9.0 to about 12.6 grams of glucose per liter solvent;   about 12.9 to about 14.8 grams of sucrose per liter solvent;   about 2.0 to about 2.3 grams of sodium chloride per liter solvent;   about 0.98 to about 1.5 grams of sodium citrate per liter solvent;   about 1.4 to about 1.6 grams of potassium citrate per liter solvent; and   about 0.50 to about 0.65 grams of dipotassium phosphate per liter solvent.   
     
     
         13 . The method of  claim 11 , wherein the at least one rehydration formulation includes at least:
 about 9.0 to about 10.8 grams of glucose per liter solvent;   about 12.6 to about 15.7 grams of sucrose per liter solvent;   about 2.0 to about 2.5 grams of sodium chloride per liter solvent;   about 0.68 to about 1.3 grams of sodium citrate per liter solvent;   about 1.4 to about 1.6 grams of potassium citrate per liter solvent; and   about 0.50 to about 0.65 grams of dipotassium phosphate per liter solvent.   
     
     
         14 . The method of  claim 11 , wherein the at least one rehydration formulation includes at least:
 about 14.0 to about 15.6 grams of dextrose per liter solvent;   about 2.1 to about 2.5 grams of sodium chloride per liter solvent;   about 2.30 to about 2.76 grams of sodium citrate per liter solvent; and   about 1.28 to about 1.88 grams of potassium chloride per liter solvent.   
     
     
         15 . A method for making a composition, the method comprising mixing at least one rehydration formulation and at least one target supplement having a first absorption rate when ingested separately from the composition,
 wherein, when the target supplement is ingested as part of the composition, the at least one target supplement has at least one of a second absorption rate that is greater than the first absorption rate.   
     
     
         16 . The method of  claim 15 , wherein the at least one hydration formulation comprises sodium, chloride, glucose-containing saccharide, potassium, and citrate. 
     
     
         17 . The method of  claim 16 , wherein the glucose osmolarity is greater than the sodium osmolarity in the composition 
     
     
         18 . The method of  claim 15 , wherein the at least one target supplement comprises at least one of: melatonin, 5-hydroxytryptophan, valerian root, L-theanine, or passionflower. 
     
     
         19 . The method of  claim 15 , wherein the at least one rehydration formulation includes at least:
 about 9.0 to about 12.6 grams of glucose per liter solvent;   about 12.9 to about 14.8 grams of sucrose per liter solvent;   about 2.0 to about 2.3 grams of sodium chloride per liter solvent;   about 0.98 to about 1.5 grams of sodium citrate per liter solvent;   about 1.4 to about 1.6 grams of potassium citrate per liter solvent; and   about 0.50 to about 0.65 grams of dipotassium phosphate per liter solvent.   
     
     
         20 . The method of  claim 15 , wherein the at least one rehydration formulation includes at least:
 about 9.0 to about 10.8 grams of glucose per liter solvent;   about 12.6 to about 15.7 grams of sucrose per liter solvent;   about 2.0 to about 2.5 grams of sodium chloride per liter solvent;   about 0.68 to about 1.3 grams of sodium citrate per liter solvent;   about 1.4 to about 1.6 grams of potassium citrate per liter solvent; and   about 0.50 to about 0.65 grams of dipotassium phosphate per liter solvent.   
     
     
         21 . The method of  claim 15 , wherein the at least one rehydration formulation includes at least:
 about 14.0 to about 15.6 grams of dextrose per liter solvent;   about 2.1 to about 2.5 grams of sodium chloride per liter solvent;   about 2.30 to about 2.76 grams of sodium citrate per liter solvent; and   about 1.28 to about 1.88 grams of potassium chloride per liter solvent.