Component analysis device, drug component analysis device, component analysis method, and drug component analysis method

Abstract

Provided is a component analysis device, which comprises an analysis unit for measuring a component fed to the plurality of containers and analyzing the component thus measured, wherein the plurality of containers are at least a first container and a second container, wherein the first container retains a first solution containing a substance that releases adhesion between multiple cells forming the liver cell tissue, and the second container retains a buffer solution, and wherein the analysis unit measures an amount of the component discharged from the liver cell tissue in the first container into the first solution and an amount of the component discharged from the liver cell tissue in the second container into the buffer solution in the second container, and analyzes an amount of the component to be discharged via a bile duct in the liver cell tissue.

1 . A component analysis device, comprising
 a retention unit for retaining a plurality of containers for retaining a liver cell tissue, and   an analysis unit for measuring a component fed to the plurality of containers and analyzing the component thus measured,   wherein the plurality of containers are at least a first container and a second container,   wherein the first container retains a first solution containing a substance that releases adhesion between multiple cells forming the liver cell tissue,   wherein the second container retains a buffer solution, and   wherein the analysis unit:   measures an amount of the component discharged from the liver cell tissue in the first container into the first solution and an amount of the component discharged from the liver cell tissue in the second container into the buffer solution in the second container, and   analyzes an amount of the component to be discharged via a bile duct in the liver cell tissue.   
     
     
         2 . The component analysis device according to  claim 1 , further comprising a temperature regulation unit for regulating a temperature of a liquid in the plurality of containers,
 wherein the plurality of containers are at least the first container, the second container, and a third container,   wherein the third container retains the buffer solution,   wherein the temperature regulation unit makes regulation so that a second temperature inside the third container is lower than a first temperature inside the first container and inside the second container, and   wherein the analysis unit measures:   an amount of the component discharged from the liver cell tissue in the third container into the buffer solution in the third container, and analyzes   an amount of the component to be discharged via a transporter in the liver cell tissue, and   an amount of the component to be discharged from other paths than the transporter and the bile duct in the liver cell tissue.   
     
     
         3 . A component analysis device, comprising
 a retention unit for retaining a plurality of containers for retaining a liver cell tissue having a drug absorbed therein,   a liquid feeding unit for feeding a liquid in the plurality of containers,   a temperature regulation unit for regulating a temperature of a liquid inside the plurality of containers, and   an analysis unit for measuring an amount of the drug in the plurality of containers and analyzing the drug thus measured,   wherein the plurality of containers are a first container, a second container, a third container, and a fourth container,   wherein the liquid feeding unit:   feeds a first solution containing a substance that releases adhesion between multiple cells forming the liver cell tissue into the fourth container,   feeds the first solution into the first container, and   feeds a buffer solution into the second container and the third container,   wherein the temperature regulation unit regulates an temperature so that a temperature inside the third container is lower than a temperature inside the first container and inside the second container, and   wherein the analysis unit analyzes:   an amount of the drug discharged from the liver cell tissue in the first container into the first solution,   an amount of the drug discharged from the liver cell tissue in the second container into the buffer solution in the second container,   an amount of the drug discharged from the liver cell tissue in the third container into the buffer solution in the third container,   an amount of the drug discharged from the liver cell tissue in the fourth container into the buffer solution in the fourth container,   an amount of the drug to be discharged from a transporter in the liver cell tissue,   an amount of the drug to be discharged from a bile duct in the liver cell tissue, and   an amount of the component to be discharged from other paths than the transporter and the bile duct in the liver cell tissue.