Topical compositions

Abstract

Compositions for dermal delivery of a topical solution and methods for using such compositions are described herein.

1 . A composition, comprising:
 an extracellular matrix component or fragment thereof having a concentration of about 0.1 wt. % to about 5 wt. % based on the total weight composition; and   a therapeutic peptide having a concentration of about 0.1 wt. % to about 25 wt. % based on the total weight composition.   
     
     
         2 . The composition of  claim 1 , wherein the extracellular matrix component or fragment thereof is selected from the group consisting of hyaluronic acid, collagen, fibronectin, elastin, lectin, and combinations thereof. 
     
     
         3 . The composition of  claim 2 , wherein collagen is selected from the group consisting of collagen type I, collagen type II, collagen type III, collagen type IV, collagen type V, fibrillary collagen, non-fibrillary collagen, and combinations thereof. 
     
     
         4 . The composition of  claim 1 , wherein the therapeutic peptide is selected from the group consisting of palmitoyl oligopeptide, palmitoyl tripeptide-1, palmitoyl tetrapeptide-7, acetyl hexapeptide-3, and combinations thereof. 
     
     
         5 . The composition of  claim 1 , comprising about 1 mg to about 1000 mg of the extracellular matrix component or a fragment thereof. 
     
     
         6 . The composition of  claim 1 , comprising about 1 mg to about 1000 mg therapeutic peptide. 
     
     
         7 . The composition of  claim 1 , wherein the concentration of therapeutic peptide is about 5 wt. % to 20 wt. %. 
     
     
         8 . The composition of  claim 1 , further comprising one or more pharmaceutical additives selected from the group consisting of diluents, fillers, disintegrants, binders, lubricants, surfactants, hydrophobic vehicles, water soluble vehicles, emulsifiers, buffers, humectants, moisturizers, solubilizers, preservatives, colorants, plastizers, carriers, excipients, or combinations thereof. 
     
     
         9 . The composition of  claim 1 , wherein the therapeutic peptide is selected from the group consisting of dipeptides, tripeptides, tetrapeptides, pentapeptides, hexapeptides, dipeptide derivatives, tripeptides derivatives, tetrapeptides derivatives, pentapeptides derivatives, hexapeptides derivatives, and combinations thereof. 
     
     
         10 . The composition of  claim 1 , further comprising one or more cosmetic additives selected from the group consisting of vitamins, cosmetic peptides, oil control agents, other skin care agents, and hydrating compositions. 
     
     
         11 . The composition of  claim 1 , wherein the composition is formulated as a liquid, cream, ointment, or gel. 
     
     
         12 . A method for treating skin, comprising topically administering a composition comprising an extracellular matrix component or fragment thereof having a concentration of about 0.1 wt. % to about 5.0 wt. % based on the total weight composition and a therapeutic peptide having a concentration of about 0.1 wt. % to about 25 wt. % based on the total weight composition. 
     
     
         13 . The method of  claim 14 , wherein the extracellular matrix component or fragment thereof is selected from the group consisting of hyaluronic acid, collagen, fibronectin, elastin, lectin, and fragments and combinations thereof. 
     
     
         14 . The method of  claim 14 , wherein the composition comprises about 1 mg to about 1000 mg of the extracellular matrix component or a fragment thereof. 
     
     
         15 . The method of  claim 14 , comprising about 0.1 wt. % to about 25 wt. % of other components.