US2021000761A1PendingUtilityA1

Topical co-enzyme q10 formulations and treatment of pain, fatigue and wounds

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Assignee: UNIV MIAMIPriority: May 2, 2006Filed: Feb 3, 2020Published: Jan 7, 2021
Est. expiryMay 2, 2026(expired)· nominal 20-yr term from priority
Inventors:Sung Lan HsiaNiven Rajin NarainIndushekhar Persaud
A61P 3/00A61K 9/10A61P 25/04A61K 9/127A61P 29/00A61K 31/122A61K 9/122A61P 21/00A61P 3/02A61P 25/00A61P 17/02A61P 19/02A61K 9/0014A61P 43/00
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Claims

Abstract

CoQ10 has a stimulatory effect on fibroblasts and keratinocytes, increases ATP production, decreases pain. The formulations are useful for promoting acute wound healing, fatigue and treatment of acute and chronic pain.

Claims

exact text as granted — not AI-modified
What is claimed is: 
     
         1 . A topical composition for the treatment of pain, fatigue and wound healing comprising CoQ10, liposomes and a pharmaceutically acceptable carrier. 
     
     
         2 . The topical composition of  claim 1 , wherein the composition comprises between about 0.001% to about 60% (w/w) of Coenzyme Q10. 
     
     
         3 . The topical composition of  claim 1 , wherein the composition is in the form of a gel. 
     
     
         4 . The topical composition of  claim 1 , wherein the composition is in the form of an ointment. 
     
     
         5 . The topical composition of  claim 1 , wherein the composition is in the form of a cream. 
     
     
         6 . The topical composition of  claim 1 , wherein the composition is in the form of a salve. 
     
     
         7 . The topical composition of  claim 1 , wherein the composition is in the form of a lotion. 
     
     
         8 . The topical composition of  claim 1 , wherein the composition is in the form of a spray. 
     
     
         9 . The topical composition of  claim 1 , wherein the composition is in the form of an aerosol. 
     
     
         10 . The topical composition of  claim 1 , wherein the composition is in the form of a mousse. 
     
     
         11 . The topical composition of  claim 1 , wherein the composition is in the form of a foam. 
     
     
         12 . A method of treating pain associated with cancer comprising topically administering to a patient in need thereof, a topical composition comprising a therapeutically effective amount of the composition of  claim 1  to the area of pain. 
     
     
         13 . A method of treating pain associated with muscle pain comprising topically administering to a patient in need thereof, a topical composition comprising a therapeutically effective amount of the composition of  claim 1  to the area of pain. 
     
     
         14 . A method of treating pain associated with joint pain comprising topically administering to a patient in need thereof, a topical composition comprising a therapeutically effective amount of the composition of  claim 1  to the area of pain. 
     
     
         15 . A method of treating pain comprising topically administering to a patient in need thereof, a topical composition comprising a therapeutically effective amount of the composition of  claim 1  to the area of pain. 
     
     
         16 . A method of treating muscle fatigue comprising topically administering to a patient in need thereof, a topical composition comprising a therapeutically effective amount of the composition of  claim 1  to the muscle. 
     
     
         17 . A method of increasing ATP production in cells or tissues, comprising administering to a patient in need thereof, a topical composition comprising a therapeutically effective amount of the composition of  claim 1  to the cells or tissues. 
     
     
         18 . A method of accelerating wound healing, comprising administering to a patient in need thereof, a topical composition comprising a therapeutically effective amount of the composition of  claim 1  to a wound. 
     
     
         19 . A method of treating burns, comprising administering to a patient in need thereof, a topical composition comprising a therapeutically effective amount of the composition of  claim 1  to a wound. 
     
     
         20 . A composition for the treatment of pain, fatigue and wound healing comprising CoQ10, liposomes, and a pharmaceutically acceptable carrier. 
     
     
         21 . The composition of  claim 20 , wherein the composition comprises between about 0.001% to about 60% (w/w) of Coenzyme Q10. 
     
     
         22 . The composition of  claim 20 , wherein said composition further comprises cytokines, growth factors, differentiation factors, hormones, analgesics and pain-killers. 
     
     
         23 . The composition of  claim 22 , wherein the cytokines are growth factors, migratory factors, monokines, lymphokines.

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