Transdermal patch providing improved permeability and composition

Abstract

A transdermal patch contains a water-based solution containing electrolytes, vitamins, and at least one permeation enhancer. The water-based solution also acts as an adhesive matrix which binds the patch together. The solution is transferred to the body via an embossed release liner. In use, the permeation of electrolytes into the bloodstream improves the body's ability to manage hydration. The permeation enhancer increases the porosity of the skin in contact with the transdermal patch to make possible the permeation of the solution into the body. Critical proportions of solvent, solutes, and permeation enhancers are disclosed which have been found to make permeation of otherwise non-absorbable ingredients possible.

What is claimed is new and desired to be protected by Letters Patent is set forth in the appended claims: 
     
         1 . A transdermal patch comprising:
 a backer;   an embossed release liner able to contact skin; and   an adhesive matrix binding the embossed release liner to the backer, the adhesive matrix containing
 water, 
 electrolytes, 
 vitamins, 
 an adhesive agent, and 
 a permeation enhancer comprising menthol. 
   
     
     
         2 . The transdermal patch of  claim 1 , wherein the permeation enhancer further comprises dimethyl sulfoxide. 
     
     
         3 . The transdermal patch of  claim 1 , wherein the permeation enhancer comprises peppermint oil. 
     
     
         4 . The transdermal patch of  claim 1 , wherein the adhesive matrix comprises between ten percent and thirty percent water. 
     
     
         5 . The transdermal patch of  claim 1 , wherein the adhesive matrix comprises polysorbate 80. 
     
     
         6 . The transdermal patch of  claim 1 , wherein the adhesive agent comprises one or more of
 sodium polyacrylate;   polyacrylic acid;   carboxymethylcellulose; and   povidone.   
     
     
         7 . The transdermal patch of  claim 1 , wherein the backer, the embossed liner, and the adhesive matrix in combination comprise a perimeter forming a water-drop shape. 
     
     
         8 . The transdermal patch of  claim 1 , wherein the adhesive matrix further comprises an external analgesic. 
     
     
         9 . The transdermal patch of  claim 1 , wherein the transdermal patch comprises a thickness of between 0.28 and 2.97 millimeters. 
     
     
         10 . The transdermal patch of  claim 1 , wherein the backer comprises a non-woven polyester. 
     
     
         11 . The transdermal patch of  claim 1 , wherein the embossed release liner comprises a silicone coating. 
     
     
         12 . The transdermal patch of  claim 1 , wherein the adhesive matrix further comprises glycerin. 
     
     
         13 . The transdermal patch of  claim 1 , wherein the electrolytes comprise one or more of potassium;
 calcium;   magnesium;   chloride;   phosphorus; and   sodium.   
     
     
         14 . The transdermal patch of  claim 1 , wherein the electrolytes comprise one or more of
 potassium gluconate;   calcium lactate;   magnesium chloride;   sodium chloride; and   monosodium phosphate monobasic.   
     
     
         15 . The transdermal patch of  claim 1 , wherein the adhesive matrix contains a proportion of menthol between 0.01 and 16 percent of a total weight of the transdermal patch. 
     
     
         16 . The transdermal patch of  claim 1 , wherein the adhesive matrix comprises between 30 and 35 milligrams of menthol. 
     
     
         17 . The transdermal patch of  claim 1 , wherein the adhesive matrix further comprises Leucine. 
     
     
         18 . The transdermal patch of  claim 1 , further comprising microneedles embedded within the embossed release liner to convey contents of the adhesive matrix to the skin. 
     
     
         19 . The transdermal patch of  claim 1 , wherein the adhesive matrix and the embossed release liner each comprise an area smaller than that of the backer, the backer further comprising
 an adhesive able to adhere the backer to the skin about the embossed release liner, the adhesive comprising a solvent and a mineral oil; and   a water-proof plastic layer.   
     
     
         20 . A transdermal patch, the transdermal patch comprising:
 a backer comprising a non-woven polyester;   an embossed release liner comprising a silicone coating; and   an adhesive matrix binding the embossed release liner to the backer, the adhesive matrix containing
 hydrogen monoxide, 
 one or more vitamins, 
 menthol, 
 dimethyl sulfoxide, 
 polysorbate 80, 
 glycerin, 
 potassium gluconate, 
 calcium lactate, 
 magnesium chloride, 
 sodium chloride, and 
 monosodium phosphate monobasic, and 
 an adhesive agent.