US2020405713A1PendingUtilityA1

Methods and compositions for sleep disorders and other disorders

Assignee: INTRA CELLULAR THERAPIES INCPriority: May 27, 2008Filed: Jul 6, 2020Published: Dec 31, 2020
Est. expiryMay 27, 2028(~1.8 yrs left)· nominal 20-yr term from priority
A61K 31/198A61P 25/24A61P 25/18C07D 471/14A61K 31/4985C07D 498/14A61K 9/0053A61K 31/5383A61K 31/44A61P 25/14A61P 5/06A61P 25/00A01N 43/42A61K 31/437A61P 25/20A61P 25/16A61K 45/06A61P 43/00
75
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Claims

Abstract

Use of particular substituted heterocycle fused gamma-carboline compounds as pharmaceuticals and pharmaceutical compositions comprising them for the treatment of one or more disorders involving the 5-HT2A, SERT and/or dopamine D2 pathways are disclosed. In addition, the compounds may be combined with other therapeutic agents for the treatment of one or more sleep disorders, depression, psychosis, dyskinesias, and/or Parkinson's disease or any combinations.

Claims

exact text as granted — not AI-modified
1 - 17 . (canceled) 
     
     
         18 . A method for the treatment of one or more sleep disorders comprising administering to a patient in need thereof a Compound of Formula I: 
       
         
           
           
               
               
           
         
       
       wherein X is O, —NH or —N(CH 3 ); and Y is —O— or —C(O)—, in free or pharmaceutically acceptable salt form. 
     
     
         19 - 39 . (canceled)

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