US2020390722A1PendingUtilityA1

Compositions and methods for the removal of ear wax

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Assignee: SPECIALTY DRUG AND DEVICE LLCPriority: Nov 9, 2016Filed: Aug 24, 2020Published: Dec 17, 2020
Est. expiryNov 9, 2036(~10.3 yrs left)· nominal 20-yr term from priority
Inventors:Chris Cagle
B65B 7/28A61K 9/0046A61K 47/12A61K 9/107A61J 7/003A61K 47/02A61J 1/06A61J 1/1412A61M 11/00A61J 7/0053A61J 1/16A61K 47/26B32B 1/00B65B 3/003A61M 2210/0662A61K 31/02A61P 27/16A61K 47/10
38
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Claims

Abstract

The present invention includes compositions and methods for the treatment, softening and removal of ear wax by administering to the ear a solution of a semi-fluorinated alkane according to the formula: RFRH or RFRHRF, wherein RF is a perfluorinated hydrocarbon segment with 20 or less carbon atoms, and RH is a non-fluorinated hydrocarbon segment with 3 to 20 carbon atoms.

Claims

exact text as granted — not AI-modified
What is claimed is: 
     
         1 . A method for the treatment, softening and removal of ear wax by administering to the ear a solution of a semi-fluorinated alkane (SFA) according to the formula:
   RFRH or RFRHRF,   wherein RF is a perfluorinated hydrocarbon segment with 20 or less carbon atoms, and RH is a non-fluorinated hydrocarbon segment with 3 to 20 carbon atoms.   
     
     
         2 . The method of  claim 1 , wherein the semifluorinated alkane is a compound of formula
   RFRH,   wherein RF is a linear perfluorinated hydrocarbon segment with 4 to 12 carbon atoms, and wherein RH is a linear alkyl group with 4 to 8 carbon atoms.   
     
     
         3 . The method of  claim 1 , wherein the semifluorinated alkane is selected from at least one of F4H5; F4H6; F4H8; F6H6; or F6H8. 
     
     
         4 . The method of  claim 1 , wherein the composition is in the form of a solution, spray or suspension, emulsions, or microemulsions. 
     
     
         5 . The method of  claim 1 , wherein the composition comprises a cosolvent that is physiologically compatible, selected from glycerol, propylene glycol, polyethylene glycol, triglyceride oils, liquid mono or diglycerides and hydrofluorocarbons. 
     
     
         6 . The method of  claim 1 , wherein the composition further comprises a surfactant selected from at least one of polysorbates, 4-(1,1,3,3-tetramethylbutyl) phenol/poly(oxyethylene) polymers, poly(oxyethylene-poly(oxypropylene) block copolymers, polyethylene glycol esters of fatty acids, or polyoxypropylene ethers of higher alkanes (C12-C18). 
     
     
         7 . The method of  claim 1 , wherein the composition further comprises a compound selected from at least one of: sodium carbonate, sodium bicarbonate, or sodium perborate. 
     
     
         8 . The method of  claim 1 , wherein the composition further comprises a demulcent that is glycerin or mineral oil. 
     
     
         9 . The method of  claim 1 , wherein the composition further comprises a demulcent present in the amount of about 1 weight/volume percent to about 20 weight/volume percent. 
     
     
         10 . The method of  claim 1 , wherein the composition further comprises a preservative selected from at least one of: benzalkonium chloride or other quarternary ammonium preservative, stabilized oxychloro complexes (Purite), sodium perborate, or mixtures thereof. 
     
     
         11 . The method of  claim 1 , wherein the composition is packaged in an acceptable container coated internally with materials to prevent vapor permeation of the SFA through the packaging material or the package is overwrapped with polymer to prevent escape of the SFA. 
     
     
         12 . The method of  claim 1 , wherein the composition is packaged in a plastic container. 
     
     
         13 . The method of  claim 1 , wherein the composition is inserted in a package fitted with a cap-sprayer of a diameter from 0.2 cm to 0.4 cm such that it is capable of being inserted into the ear canal, and the cap-sprayer is cap is from 1.9 cm to 2.4 cm in length. 
     
     
         14 . The method of  claim 1 , wherein the composition is inserted in a package fitted with a cap-sprayer with an extension for fitting into the ear canal. 
     
     
         15 . The method of  claim 1 , wherein the composition is in cotton buds wetted with that composition. 
     
     
         16 . The method of  claim 1 , wherein the composition is in cotton buds wetted with that composition in individually sealed in an acceptable unit-of-use packaging material, wherein the packaging material is capable of preventing diffusion of the composition from the package. 
     
     
         17 . The method of  claim 1 , wherein the composition is adapted for administration to an animal. 
     
     
         18 . The method of  claim 1 , wherein the composition is an emulsion comprising about 40 wt-% SFA to 60 wt-% water, to SFA and 60 wt-% to 40 wt-% water. 
     
     
         19 . The method of  claim 1 , wherein the composition is an emulsion with a particle size of at least 5 nm and less than 200 nm. 
     
     
         20 . The method of  claim 1 , wherein the composition is a microemulsion in a liquid composed of 20 to 95 wt-% SFA. 
     
     
         21 . A composition for the treatment, softening and removal of ear wax by administering to the ear a solution of a semi-fluorinated alkane (SFA) according to the formula:
   RFRH or RFRHRF,   wherein RF is a perfluorinated hydrocarbon segment with 20 or less carbon atoms, and RH is a non-fluorinated hydrocarbon segment with 3 to 20 carbon atoms, and the composition is adapted for administration to the ear canal.   
     
     
         22 . The composition of  claim 21 , wherein the semifluorinated alkane is selected from F4H5; F4H6; F4H8; F6H6 and F6H8. 
     
     
         23 . The composition of  claim 21 , wherein the composition is in the form of a solution, spray or suspension, emulsions, or microemulsions. 
     
     
         24 . The composition of  claim 21 , wherein the composition further comprises a cosolvent that is physiologically compatible, selected from glycerol, propylene glycol, polyethylene glycol, triglyceride oils, liquid mono or diglycerides and hydrofluorocarbons. 
     
     
         25 . The composition of  claim 21 , wherein the composition further comprises a surfactant selected from at least one of polysorbates, 4-(1,1,3,3-tetramethylbutyl) phenol/poly(oxyethylene) polymers, poly(oxyethylene-poly(oxypropylene) block copolymers, polyethylene glycol esters of fatty acids, or polyoxypropylene ethers of higher alkanes (C 12 -C 18 ). 
     
     
         26 . The composition of  claim 21 , wherein the composition is an emulsion comprising about 40 wt-% SFA to 60 wt-% water, to SFA and 60 wt-% to 40 wt-% water. 
     
     
         27 . The composition of  claim 21 , wherein the composition is an emulsion with a particle size of at least 5 nm and less than 200 nm. 
     
     
         28 . The composition of  claim 21 , wherein the composition is a microemulsion in a liquid composed of 20 to 95 wt-% SFA.

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