US2020384155A1PendingUtilityA1

Cardiovascular Prostheses

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Assignee: CORMATRIX CARDIOVASCULAR INCPriority: Dec 16, 2011Filed: Aug 11, 2020Published: Dec 10, 2020
Est. expiryDec 16, 2031(~5.4 yrs left)· nominal 20-yr term from priority
Inventors:Robert G. Matheny
A61F 2250/0067A61K 31/4418A61L 27/58A61L 27/54A61L 27/3834A61L 27/34A61L 27/3633A61F 2210/0004A61L 2300/414A61F 2/0095A61F 2/06A61L 27/507A61L 2430/20A61F 2/00
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Claims

Abstract

Cardiovascular prostheses for treating, reconstructing and replacing damaged or diseased cardiovascular tissue that are formed from acellular extracellular matrix (ECM). The cardiovascular prostheses comprise an ECM-mimicking composition comprising poly(glycerol sebacate) (PGS) and a cytokine.

Claims

exact text as granted — not AI-modified
What is claimed is: 
     
         1 . A cardiovascular prosthesis, comprising:
 an ECM-mimicking composition comprising poly(glycerol sebacate) (PGS) and a cytokine,   said ECM-mimicking composition, when disposed proximate damaged biological tissue, being adapted to modulate inflammation of said damaged biological tissue.   
     
     
         2 . The cardiovascular prosthesis of  claim 1 , wherein said cytokine comprises an interleukin. 
     
     
         3 . The cardiovascular prosthesis of  claim 2 , wherein said interleukin is selected from the group consisting of interleukin-8 (IL-8) and interleukin-10 (IL-10).

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