US2020376073A1PendingUtilityA1

Method of treating low blood pressure

79
Assignee: THE GEORGE WASHINGTON UNIV A CONGRESSIONALLY CHARTERED NOT FOR PROFIT CORPORATIONPriority: Dec 16, 2009Filed: Dec 23, 2019Published: Dec 3, 2020
Est. expiryDec 16, 2029(~3.4 yrs left)· nominal 20-yr term from priority
Inventors:Lakhmir Chawla
A61K 38/085A61P 9/00
79
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Claims

Abstract

A method for treating a patient suffering from one of septic shock, acute kidney injury, severe hypotension, cardiac arrest, and refractory hypotension, but not from myocardial infarction, is provided. The method includes administering a therapeutically effective dose of Angiotensin II, or Ang II, to the patient.

Claims

exact text as granted — not AI-modified
1 .- 29 . (canceled) 
     
     
         30 . A method of treating severe hypotension in a human subject, comprising administering Angiotensin II to the human subject by intravenous infusion at an initial rate of about 20 ng/kg/min. 
     
     
         31 . The method of  claim 30 , further comprising titrating the rate up to about 30 ng/kg/min. 
     
     
         32 . The method of  claim 30 , further comprising titrating the rate up to about 40 ng/kg/min. 
     
     
         33 . The method of  claim 30 , wherein the rate is titrated up one or more times by about 10 ng/kg/min. 
     
     
         34 . The method of  claim 30 , wherein the Angiotensin II is administered to the human subject over a period of about 0.25 hours to about 120 hours. 
     
     
         35 . The method of  claim 34 , wherein the Angiotensin II is administered to the human subject over a period of about 1 hour to about 7 hours. 
     
     
         36 . The method of  claim 30 , wherein the rate of administration of Angiotensin II is titrated to achieve a mean arterial pressure of about 65 mmHg. 
     
     
         37 . The method of  claim 30 , wherein the rate of administration of Angiotensin II is titrated to achieve a mean arterial pressure of 65 mmHg. 
     
     
         38 . The method of  claim 36 , wherein the mean arterial pressure is maintained at about 65 mmHg for about 0.25 hours to about 120 hours. 
     
     
         39 . The method of  claim 38 , wherein the mean arterial pressure is maintained at about 65 mmHg for about 1 hour to about 7 hours. 
     
     
         40 . The method of  claim 30 , wherein the subject has septic shock. 
     
     
         41 . The method of  claim 30 , wherein the severe hypotension is refractory hypotension. 
     
     
         42 . The method of  claim 30 , wherein the human subject is undergoing treatment with one or more vasopressors. 
     
     
         43 . The method of  claim 42 , wherein the one or more vasopressors is selected from the group consisting of norepinephrine, vasopressin, epinephrine, and dopamine. 
     
     
         44 . The method of  claim 43 , wherein the one or more vasopressors is norepinephrine. 
     
     
         45 . The method of  claim 43 , wherein the one or more vasopressors is vasopressin. 
     
     
         46 . The method of  claim 42 , further comprising titrating the rate up to about 30 ng/kg/min. 
     
     
         47 . The method of  claim 42 , further comprising titrating the rate up to about 40 ng/kg/min. 
     
     
         48 . The method of  claim 42 , wherein the rate is titrated up one or more times by about 10 ng/kg/min. 
     
     
         49 . The method of  claim 42 , wherein the Angiotensin II is administered to the human subject over a period of about 0.25 hours to about 120 hours. 
     
     
         50 . The method of  claim 49 , wherein the Angiotensin II is administered to the human subject over a period of about 1 hour to about 7 hours. 
     
     
         51 . The method of  claim 42 , wherein the rate of administration of Angiotensin II is titrated to achieve a mean arterial pressure of about 65 mmHg. 
     
     
         52 . The method of  claim 42 , wherein the rate of administration of Angiotensin II is titrated to achieve a mean arterial pressure of 65 mmHg. 
     
     
         53 . The method of  claim 51 , wherein the mean arterial pressure is maintained at about 65 mmHg for about 0.25 hours to about 120 hours. 
     
     
         54 . The method of  claim 53 , wherein the mean arterial pressure is maintained at about 65 mmHg for about 1 hour to about 7 hours. 
     
     
         55 . A method of treating severe hypotension in a human subject, comprising administering Angiotensin II to the human subject by intravenous infusion at a rate of from about 20 ng/kg/min to about 40 ng/kg/min. 
     
     
         56 . The method of  claim 55 , wherein the Angiotensin II is administered at a rate of about 30 ng/kg/min. 
     
     
         57 . The method of  claim 55 , wherein the Angiotensin II is administered at a rate of about 40 ng/kg/min. 
     
     
         58 . The method of  claim 55 , wherein the subject has septic shock. 
     
     
         59 . The method of  claim 55 , wherein the severe hypotension is refractory hypotension.

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