Immunity-boosting agent, immuno-therapeutic anti-cancer agent, and anti-cancer therapy adverse effect mitigating agent containing anthocyanin-fucoidan complex as active ingredient

Abstract

The present invention relates to a composition including an anthocyanin-fucoidan complex formed by ionic bond between anthocyanin and fucoidan as an active ingredient, and more particularly, it is confirmed that the anthocyanin-fucoidan complex in which anion of the fucoidan, which is a natural extract having high biocompatibility and biodegradability, is ionically bonded with a cation of the anthocyanin improves the stability and the solubility of the anthocyanin even in acidic conditions in vivo, thereby increasing the immune activity in vivo and therefore it is intended to provide the anthocyanin-fucoidan complex as an immune enhancer, an immune-cancer agent and an anticancer adjuvant composition for alleviating side effects of anti-cancer agents.

1 - 3 . (canceled) 
     
     
         4 . An immune enhancer comprising an aronia extract-fucoidan complex composed of an aronia extract and a fucoidan, wherein an ionic bond is formed between a cation of a cyanidine of the aronia extract and an anion of the fucoidan, and π-π bonds are formed between the cyanidine molecules, as an active ingredient. 
     
     
         5 . The immune enhancer of  claim 4 , wherein the aronia extract-fucoidan complex induces an expression of immune factors to increase an activity of immune cells. 
     
     
         6 . A method of inhibiting carcinogenesis in a subject in need thereof, comprising:
 providing a pharmaceutical composition comprising an aronia extract-fucoidan complex composed of an aronia extract and a fucoidan, wherein an ionic bond is formed between a cation of a cyanidine of the aronia extract and an anion of the fucoidan, and π-π bonds are formed between the cyanidine molecules, as an active ingredient; and   administering the pharmaceutical composition to the subject, wherein the carcinogenesis is inhibited.   
     
     
         7 . The method of  claim 6 , wherein the aronia extract-fucoidan complex induces an expression of immune factors to increase an activity of immune cells and kill cancer cells. 
     
     
         8 . The method of  claim 7 , wherein the cancer cells are cancer cells of solid cancers. 
     
     
         9 . (canceled) 
     
     
         10 . An anticancer adjuvant comprising an aronia extract-fucoidan complex composed of an aronia extract and a fucoidan, wherein an ionic bond is formed between a cation of a cyanidine of the aronia extract and an anion of the fucoidan, and π-π bonds are formed between the cyanidine molecules, as an active ingredient. 
     
     
         11 . The anticancer adjuvant of  claim 10 , wherein the anticancer adjuvant relieves side effects caused by administration of an anticancer agent. 
     
     
         12 . The anticancer adjuvant of  claim 11 , wherein the side effects caused by administration of the anticancer agent are selected from the group consisting of weight loss, immune factor reduction and cachexia.