Compositions of psilocybin and analogs

Abstract

Methods and compositions are disclosed for enhancing neurogenesis, resolving neuropathy and improving neurological health and functioning using fungal extracts and their active ingredients, including species of mushrooms and mycelia containing psilocybin and psilocin, combined with erinacines and hericenones or fungal extracts containing those active ingredients, with the addition of nicotinic acid. The compositions may optionally be combined with nervine plants.

What is claimed: 
     
         1 . A composition comprising:
 psilocybin, psilocin, baeocystin, norbaeocystin, salts thereof, or combinations thereof;   an erinacine, a hericenone, or a combination thereof.   
     
     
         2 . The composition of  claim 1 , further comprising: niacin. 
     
     
         3 . The composition of  claim 1 , further comprising one or more pharmaceutically acceptable excipients comprising selected from buffering agents, antimicrobial preservatives, antioxidants, suspension agents, a tablet or capsule diluent, or a tablet disintegrant. 
     
     
         4 . The composition of  claim 1 , further comprising one or more  Bacopa  species ( Bacopa monnien ), Gotu kola ( Centella asiatica ), Gingko ( Gingko biloba ), Ginger ( Zingiber officinale ), Holy Basil ( Ocimum sanctum ), Hu Zhang ( Polygonum cuspidatum ), Oregano ( Origanum vulgare, Origanum onites ), Rosemary ( Rosmarinus officinalis, Rosmarinus eriocalyx, Rosmarinus  species), Turmeric ( Curcuma longa ), Green Tea ( Camellia sinensis ), lavender ( Lavandula spica  and  Lavandula  species), skullcap ( Scutellaria lateriflora ), oat straw ( Avena sativa  and  Avena byzantine ), Diviner's Sage ( Salvia divinorum ), ayahuasca ( Banisteriopsis caapi  and  Psychotria  species),  Tabernanthe iboga, Voacanga africana, Tabernaemontana undulate , peyote ( Lophophora williamsii ), morning glory ( Ipomoea tricolor, Argyreia nervosa ),  Cannabis sativa, Cannabis indica  or  Cannabis ruderalis , extracts thereof, or combinations thereof. 
     
     
         5 . The composition of  claim 1 , wherein the composition further comprises: mycelia, fruitbodies, or extracts thereof of  Antrodia, Beauveria, Copelandia, Cordyceps, Ganoderma, Grifola, Hericium, Inonotus, Isaria, Panaeolus, Phellinus , or combinations thereof. 
     
     
         6 . A method for treating or improving neurological functioning or mental health in a subject in need thereof comprising administration of an effective amount of the composition of  claim 1  to the subject in need thereof. 
     
     
         7 . The method of  claim 6 , where the neurological or mental health conditions comprise depression, memory loss, dementia, cognitive dysfunction, hearing loss, vision loss, neurologic pain, or combinations thereof. 
     
     
         8 . A composition comprising:
 psilocybin, psilocin, baeocystin, norbaeocystin, salts thereof, or combinations thereof;   an erinacine, a hericenone, or a combination thereof; and   niacin.   
     
     
         9 . The composition of  claim 8 , further comprising one or more  Bacopa  species ( Bacopa monnien ), Gotu kola ( Centella asiatica ), Gingko ( Gingko biloba ), Ginger ( Zingiber officinale ), Holy Basil ( Ocimum sanctum ), Hu Zhang ( Polygonum cuspidatum ), Oregano ( Origanum vulgare, Origanum onites ), Rosemary ( Rosmarinus officinalis, Rosmarinus eriocalyx, Rosmarinus  species), Turmeric ( Curcuma longa ), Green Tea ( Camellia sinensis ), lavender ( Lavandula spica  and  Lavandula  species), skullcap ( Scutellaria lateriflora ), oat straw ( Avena sativa  and  Avena byzantine ), Diviner's Sage ( Salvia divinorum ), ayahuasca ( Banisteriopsis caapi  and  Psychotria  species),  Tabernanthe iboga, Voacanga africana, Tabernaemontana undulate , peyote ( Lophophora williamsii ), morning glory ( Ipomoea tricolor, Argyreia nervosa ),  Cannabis sativa, Cannabis indica  or  Cannabis ruderalis , extracts thereof, or combinations thereof. 
     
     
         10 . A method for treating or improving neurological functioning or mental health in a subject in need thereof comprising administration of an effective amount of the composition of  claim 8  to the subject in need thereof. 
     
     
         11 . The method of  claim 10 , wherein the neurological or mental health conditions comprise depression, memory loss, dementia, cognitive dysfunction, hearing loss, vision loss, neurologic pain, or combinations thereof. 
     
     
         12 . A composition comprising:
 4-phospho-N,N-dimethyltryptamine (4-PO-DMT; psilocybin), 4-hydroxy-N,N-dimethyltryptamine (4-HO-DMT; psilocin), 4-phospho-N-methyl tryptamine (baeocystin), 4-phospho-tryptamine (4-PO-T, norbaeocystin), 1-methylpsilocin, N,N-dimethyltryptamine (DMT), 5-hydroxytryptamine (5-HT; serotonin), 5-hydroxytryptophan (5-HTP), 4-acetoxy-N,N-dimethyltryptamine (4-AcO-DMT), 4-acetoxy-N-methyl-N-ethyltryptamine (4-AcO-MET), 4-acetoxy-N,N-diethyltryptamine (4-AcO-DET), 4-acetoxy-N-methyl-N-propyltryptamine (4-AcO-M PT), 4-acetoxy-N-methyl-N-isopropyltryptamine (4-AcO-MIPT), 4-acetoxy-N,N-dipropyltryptamine (4-AcO-DPT), 4-acetoxy-N,N-diisopropyltryptamine (4-AcO-DI PT), 4-hydroxy-N-methyl-N-ethyltryptamine (4-OH-MET), 4-hydroxy-N-methyl-N-propyltryptamine (4-OH-MPT), 4-hydroxy-N-methyl-N-isopropyltryptamine (4-OH-MI PT), 4-hydroxy-N,N-diethyltryptamine (4-OH-DET), 4-hydroxy-N,N-dipropyltryptamine (4-OH-DPT), 4-hydroxy-N,N-diisopropyltryptamine (4-OH-DI PT), 4-hydroxy-N,N-diallyltryptamine (4-OH-DALT), N-dimethyltryptamine (DMT), N-methyl-N-ethyltryptamine (MET), N-methyl-N-propyltryptamine (MPT), N,N-diethyltryptamine (DET), N,N-dipropyltryptamine (DPT), N,N-isopropyltryptamine (DIPT), N-methyl-N-isopropyltryptamine (MIPT), α-methyltryptamine (AMT), N-ethyl-N-isopropyltryptamine (EIPT), N-methyl-N-butyl-tryptamine (MBT), N,N-dimethyl-5-hydroxytryptamine (5-OH-DMT), 5-methoxy-α-methyltryptamine (5-MeO-αMT), 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT; bufotenin), 5-methoxy-N,N-diethyltryptamine (5-MeO-DET), 5-methoxy-N,N-dipropyltryptamine (5-MeO-DPT), 5-methoxy-N,N-diisopropyltryptamine (5-MeO-DIPT), 5-methoxy-N-ethyl-N-isopropyltryptamine (5-MeO-EIPT), 2,α-dimethyltryptamine (2,α-DMT), α,N-dimethyltryptamine (α,N-DMT), α-ethyltryptamine (α-ET), 2-methyl-N,N-dimethyltryptamine (2-Me-DMT), 2-methyl-N,N-diethyltryptamine (2-Me-DET), 12-methoxyibogamine (ibogaine), salts thereof, or combinations thereof; and   an erinacine, a hericenone, or a combination thereof.   
     
     
         13 . The composition of  claim 12 , further comprising: niacin. 
     
     
         14 . The composition of  claim 12 , comprising one or more  Bacopa  species ( Bacopa monnien ), Gotu kola ( Centella asiatica ), Gingko ( Gingko biloba ), Ginger ( Zingiber officinale ), Holy Basil ( Ocimum sanctum ), Hu Zhang ( Polygonum cuspidatum ), Oregano ( Origanum vulgare, Origanum onites ), Rosemary ( Rosmarinus officinalis, Rosmarinus eriocalyx, Rosmarinus  species), Turmeric ( Curcuma longa ), Green Tea ( Camellia sinensis ), lavender ( Lavandula spica  and  Lavandula  species), skullcap ( Scutellaria lateriflora ), oat straw ( Avena sativa  and  Avena byzantine ), Diviner's Sage ( Salvia divinorum ), ayahuasca ( Banisteriopsis caapi  and  Psychotria  species),  Tabernanthe iboga, Voacanga africana, Tabernaemontana undulate , peyote ( Lophophora williamsii ), morning glory ( Ipomoea tricolor, Argyreia nervosa ),  Cannabis sativa, Cannabis indica  or  Cannabis ruderalis , extracts thereof, or combinations thereof. 
     
     
         15 . A method for treating or improving neurological functioning or mental health in a subject in need thereof comprising administration of an effective amount of the composition of  claim 12  to the subject in need thereof. 
     
     
         16 . The method of  claim 15  wherein the neurological or mental health conditions comprise depression, memory loss, dementia, cognitive dysfunction, hearing loss, vision loss, neurologic pain, or combinations thereof.