Methods and Compositions for Treating a Renal Disease Condition in a Subject

Abstract

Methods for treating a renal associated disease condition in a subject are provided. The subject methods are characterized by modulating at least one portion of the subject's autonomic nervous system in a manner effective to treat a renal condition in the subject. Specifically, the methods may include modulating, e.g., increasing, a parasympathetic/sympathetic activity ratio in the subject. Also provided are compositions, kits and systems for practicing the subject methods.

1 . A method of treating a renal associated condition in a subject, said method comprising:
 modulating at least one portion of the autonomic nervous system in said subject, whereby said modulating is in a manner effective to treat said subject for said renal condition, wherein said modulating comprising increasing a parasympathetic/sympathetic activity ratio in said subject.   
     
     
         2 . The method of  claim 1 , wherein said modulating comprises administering an effective amount of a pharmacological agent to said subject. 
     
     
         3 . The method of  claim 2 , wherein said pharmacological agent is an autonomic nervous system modulator. 
     
     
         4 . The method of  claim 1 , wherein said method comprises increasing parasympathetic activity. 
     
     
         5 . The method of  claim 1 , wherein said method comprises decreasing sympathetic activity. 
     
     
         6 . The method of  claim 1 , wherein said method comprises increasing parasympathetic activity and decreasing sympathetic activity. 
     
     
         7 . The method of  claim 1 , wherein said modulation is accomplished by at least applying electrical energy from an electrical energy applying device to said at least one portion of said autonomic nervous system. 
     
     
         8 . The method of  claim 7 , wherein said application of electrical energy comprises electrically increasing activity in at least one portion of said autonomic nervous system. 
     
     
         9 . The method of  claim 8 , wherein said application of electrical energy comprises electrically inhibiting activity in at least one portion of said autonomic nervous system. 
     
     
         10 . The method of  claim 7 , wherein said method comprises increasing parasympathetic activity. 
     
     
         11 . The method of  claim 7 , wherein said method comprises decreasing sympathetic activity. 
     
     
         12 . The method of  claim 7 , wherein said method comprises increasing parasympathetic activity and decreasing sympathetic activity. 
     
     
         13 . The method of  claim 7 , wherein said method further comprises administering an effective amount of a pharmacological agent to said subject. 
     
     
         14 . The method of  claim 13 , wherein said method comprises increasing parasympathetic activity. 
     
     
         15 . The method of  claim 13 , wherein said method comprises decreasing sympathetic activity. 
     
     
         16 . The method of  claim 13 , wherein said method comprises increasing parasympathetic activity and decreasing sympathetic activity. 
     
     
         17 . The method of  claim 1 , wherein said renal associated condition comprises a member selected from the group consisting of acute renal failure, chronic renal failure, contrast nephropathy, and cardiorenal syndrome. 
     
     
         18 . The method of  claim 17 , wherein said renal condition is cardiorenal syndrome. 
     
     
         19 . The method of  claim 17 , wherein said renal condition is contrast nephropathy. 
     
     
         20 . The method of  claim 17 , wherein said contrast nephropathy is iodine-based contrast nephropathy. 
     
     
         21 - 27 . (canceled)