Saliva glucose measurement devices and methods

Abstract

Devices and methods capable of detecting glucose in saliva (FIG. 12). The devices feature a sensor having a substrate containing electrodes and one or more reagents on the electrodes. A detection device is operably coupled with the sensor to detect glucose based on measurement of an electrical parameter when electricity is applied to the electrodes.

1 . A device configured to detect glucose in saliva, comprising:
 a sensor having a substrate containing electrodes and one or more glucose-detection reagents on said electrodes, wherein said one or more reagents comprises GDH and ferricyanide in 1×PBS buffer;   a sulfonated tetrafluoroethylene-based fluoropolymer-copolymer coating or mesoporous carbon coating on one or more of the electrodes; and   a detection device operably coupled with said sensor to detect said glucose based on measurement of an electrical parameter when electricity is applied to said electrodes.   
     
     
         2 . (canceled) 
     
     
         3 . (canceled) 
     
     
         4 . The sensor device of  claim 1 , wherein said reagents are in dry form. 
     
     
         5 . The sensor of  claim 1 , wherein said one or more reagents further comprise glucose dehydrogenase flavine-adenine dinucleotide (GDH-FAD). 
     
     
         6 .- 14 . (canceled) 
     
     
         15 . A device configured to detect glucose in saliva, comprising:
 a sensor having a substrate containing electrodes and one or more glucose-detection reagents on said electrodes, wherein said one or more reagents comprises GDH-FAD and ferricyanide in 1×PBS buffer;   a sulfonated tetrafluoroethylene-based fluoropolymer-copolymer coating or mesoporous carbon coating on one or more of the electrodes; and   a detection device operably coupled with said sensor to detect said glucose based on measurement of an electrical parameter when electricity is applied to said electrodes.   
     
     
         16 . The sensor device of  claim 15 , wherein said reagents are in dry form.