Methods and compositions for treating aging-associated conditions

Abstract

Methods and compositions are provided for treating a subject for aging-associated conditions, e.g., cognitive impairment conditions. Aspects of the methods include administering a young plasma-comprising blood product to an individual in need thereof, e.g., an individual suffering from or at risk of developing the aging-associated condition, e.g., aging-associated cognitive impairment. Also provided are compositions and kits thereof that find use in practicing methods of the invention.

1 - 19 . (canceled) 
     
     
         20 . A kit comprising:
 two or more containers, wherein each container comprises:
 a young plasma product; and 
 identifying information comprising age related data of the young plasma product donor. 
   
     
     
         21 . The kit according to  claim 20 , wherein the age related data comprises the age of the young plasma product donor at the time of harvest. 
     
     
         22 . The kit according to  claim 20 , wherein the young plasma product lacks erythrocytes. 
     
     
         23 . The kit according to  claim 20 , wherein the young plasma product lacks leukocytes. 
     
     
         24 . The kit according to  claim 20 , wherein the young plasma product is acellular. 
     
     
         25 . The kit according to  claim 20 , wherein the young plasma product lacks proteins having an average molecular weight that is below a predetermined threshold. 
     
     
         26 . The kit according to  claim 20 , wherein the young plasma product is obtained from a donor that is 40 years old or less. 
     
     
         27 . The kit according to  claim 26 , wherein the young plasma product is obtained from an umbilical cord of a newborn. 
     
     
         28 . A method of producing a blood product for use in treating an aging-associated cognitive impairment in a subject, the method comprising:
 removing proteins having an average molecular weight that is below a predetermined threshold from a plasma-comprising blood product from a young donor to produce a blood product for use in treating aging-associated cognitive impairment.   
     
     
         29 . The method according to  claim 28 , wherein the removing comprises size exclusion chromatography. 
     
     
         30 . The method according to  claim 28 , wherein the plasma-comprising blood product is harvested from a young donor by plasmapheresis. 
     
     
         31 . The method according to any of  claims 28  to  30   claim 28 , wherein the plasma-comprising blood product is prepared by a method comprising:
 adding anticoagulant to whole blood harvested from a young donor, 
 centrifuging the anticoagulant-treated blood at a rate effective to pellet cells in the blood, and 
 collecting the supernatant, wherein the supernatant is the plasma-comprising blood product. 
 
     
     
         32 . The method according to  claim 31 , wherein the method further comprises cryopreserving the blood product prior to or after removing proteins having an average molecular weight that is below a predetermined threshold. 
     
     
         33 . The method according to any of  claim 28 , wherein the donor is a human. 
     
     
         34 . The method according to  claim 33 , wherein the donor is 40 years old or younger. 
     
     
         35 . A blood product for use in treating a subject for an aging-associated condition, the blood product prepared according to  claim 28 .