Methods of treating age-related symptoms in mammals and compositions therefor

Abstract

A method of alleviating age-related symptoms in a mammal, which comprises a step of administering to a mammal in need thereof, an effective amount of a composition containing an effective amount of at least methylene blue.

1 . A method of alleviating age-related symptoms in a mammal, the method comprising administering to a mammal in need thereof an effective amount of a composition containing an effective amount of methylene blue. 
     
     
         2 . (canceled) 
     
     
         3 . (canceled) 
     
     
         4 . The method of  claim 1 , wherein the composition comprises a topical formulation and is applied to skin of the mammal in need thereof. 
     
     
         5 . (canceled) 
     
     
         6 . The method of  claim 1 , wherein the composition comprises an oral formulation and is administered orally to the mammal in need thereof. 
     
     
         7 . (canceled) 
     
     
         8 . The method of  claim 1 , wherein the age-related symptoms are caused by Hutchinson-Gilford progeria syndrome (HGPS). 
     
     
         9 . The method of  claim 1 , wherein the age-related symptoms are caused by normal aging. 
     
     
         10 . The method of  claim 1 , wherein said alleviating of age-related symptoms comprises inducing clearance of progerin from the cells of the mammal. 
     
     
         11 . The method of  claim 10 , wherein said clearance comprises release of said progerin from cellular nuclear membranes and solubilization of said released progerin from said cellular nuclear membranes. 
     
     
         12 . The method of  claim 1 , wherein the mammal is a human. 
     
     
         13 . The method of  claim 8 , wherein said age-related symptoms are alleviated by restoring perinuclear heterochromatin and correcting misregulated gene expression. 
     
     
         14 - 20 . (canceled) 
     
     
         21 . The method of  claim 1 , wherein the composition comprises no more than 1 micromolar (1 μM) of methylene blue. 
     
     
         22 . The method of  claim 1 , wherein the composition is in a form of lotion, cream, gel, spray, ointment, soap, drop or transdermal patch.