US2020324002A1PendingUtilityA1

Radiopharmaceutical synthesis methods

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Assignee: LANTHEUS MEDICAL IMAGING INCPriority: Apr 10, 2012Filed: Jan 17, 2020Published: Oct 15, 2020
Est. expiryApr 10, 2032(~5.7 yrs left)· nominal 20-yr term from priority
Inventors:Richard R. CesatiJames F. Castner
A61K 51/04A61K 51/0491A61K 51/0406A61K 51/0459A61K 51/0453A61K 51/0455C07B 59/00A61K 51/0402A61K 51/121
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Claims

Abstract

The invention relates to products and methods that provide increased yields of certain radiopharmaceuticals.

Claims

exact text as granted — not AI-modified
1 - 14 . (canceled) 
     
     
         15 . A method comprising:
 passing a composition comprising an  18 F-bearing radiopharmaceutical through a hydrophilic polytetrafluoroethylene filter to achieve a filtered composition, wherein recovery of the  18 F-bearing radiopharmaceutical after passage through the filter is greater than about 90%, wherein the  18 F-bearing radiopharmaceutical is:   
       
         
           
           
               
               
           
         
       
     
     
         16 . The method of  claim 15 , wherein the composition comprising the  18 F-bearing radiopharmaceutical is a composition of the  18 F-bearing radiopharmaceutical in an aqueous solution comprising 3-5 wt % ethanol. 
     
     
         17 . The method of  claim 15 , wherein the composition comprises ascorbic acid. 
     
     
         18 . The method of  claim 17 , wherein the concentration of ascorbic acid is about 50 mg/mL. 
     
     
         19 . The method of  claim 15 , wherein the composition has a pH of about 5.8. 
     
     
         20 . The method of  claim 15 , wherein the composition further comprises about 50 mg/mL ascorbic acid and has a pH of about 5.8. 
     
     
         21 . The method of  claim 15 , wherein recovery of the  18 F-bearing radiopharmaceutical after passage through the filter is greater than 95%. 
     
     
         22 . A method comprising:
 passing a composition comprising an  18 F-bearing radiopharmaceutical through a hydrophilic polytetrafluoroethylene filter to achieve a filtered composition, wherein retention of the  18 F-bearing radiopharmaceutical after passage through the filter is less than 5% wherein the  18 F-bearing radiopharmaceutical is:   
       
         
           
           
               
               
           
         
       
     
     
         23 . The method of  claim 22 , wherein the composition comprising the  18 F-bearing radiopharmaceutical is a composition of the  18 F-bearing radiopharmaceutical in an aqueous solution comprising 3-5 wt % ethanol. 
     
     
         24 . The method of  claim 22 , wherein the composition comprises ascorbic acid. 
     
     
         25 . The method of  claim 24 , wherein the concentration of ascorbic acid is about 50 mg/mL. 
     
     
         26 . The method of  claim 22 , wherein the composition has a pH of about 5.8. 
     
     
         27 . The method of  claim 22 , wherein the composition further comprises about 50 mg/mL ascorbic acid and has a pH of about 5.8. 
     
     
         28 . The method of  claim 22 , wherein retention of the  18 F-bearing radiopharmaceutical after passage through the filter is less than 4%. 
     
     
         29 . The method of  claim 22 , wherein retention of the  18 F-bearing radiopharmaceutical after passage through the filter is less than 3%.

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