Kaempferol analog-containing composition

Abstract

The present application provides a composition for improvement in physical activity efficiency, a composition for reducing fatigue, and a composition for improving dynamic/kinetic visual acuity, comprising a kaempferol analog.

1 . A composition for improvement in physical activity efficiency, comprising a kaempferol analog of Formula I: 
       
         
           
           
               
               
           
         
         or a glycoside thereof, wherein:
 R 1  is —OH, or —OCH 3 ; 
 R 2  is H, or —OH; 
 R 3  is H, —OH, or —OCH 3 ; 
 R 4  is —OH, or —OCH 3 ; 
 R 5  is H, or —OH; and 
 R 6  is H, —OH, or —OCH 3 ; 
 
         excluding the following compound: 
       
       
         
           
           
               
               
           
         
       
     
     
         2 . The composition according to  claim 1 , wherein the improvement in physical activity efficiency is improvement in endurance. 
     
     
         3 . The composition according to  claim 1 , wherein the improvement in physical activity efficiency is reduction of breathlessness. 
     
     
         4 . A composition for reducing fatigue, comprising a kaempferol analog of Formula I: 
       
         
           
           
               
               
           
         
         or a glycoside thereof, wherein:
 R 1  is —OH, or —OCH 3 ; 
 R 2  is H, or —OH; 
 R 3  is H, —OH, or —OCH 3 ; 
 R 4  is —OH, or —OCH 3 ; 
 R 5  is H, or —OH; and 
 R 6  is H, —OH, or —OCH 3 ; 
 
         excluding the following compound: 
       
       
         
           
           
               
               
           
         
       
     
     
         5 . A composition for improving dynamic/kinetic visual acuity, comprising a kaempferol analog of Formula I: 
       
         
           
           
               
               
           
         
         or a glycoside thereof, wherein:
 R 1  is —OH, or —OCH 3 ; 
 R 2  is H, or —OH; 
 R 3  is H, —OH, or —OCH 3 ; 
 R 4  is —OH, or —OCH 3 ; 
 R 5  is H, or —OH; and 
 R 6  is H, —OH, or —OCH 3 ; 
 
         excluding the following compound: 
       
       
         
           
           
               
               
           
         
       
     
     
         6 . The composition according to  claim 1 , wherein the glycoside of kaempferol analog is represented by Formula I, wherein:
 at least one selected from R 1 , R 2 , R 4 , and R 6  is independently selected from —OR 7 , —OR 7 R 8 , and —OR 7 R 8 R 9 ;   R 7  is a glucose residue; and   R 8  and R 9  are independently selected from a glucose residue, a mannose residue, a galactose residue, a fucose residue, a rhamnose residue, an arabinose residue, a xylose residue, a fructose residue, a glucuronic acid residue, and an apiose residue.   
     
     
         7 . The composition according to  claim 1 , wherein the kaempferol analog or a glycoside thereof is selected from the group consisting of the following: 
       
         
           
           
               
               
           
         
         
           
           
               
               
           
         
         and a glycoside thereof. 
       
     
     
         8 . The composition according to  claim 1 , wherein the kaempferol analog or a glycoside thereof is kaempferol or kaempferol 3-O-glucoside. 
     
     
         9 . The composition according to  claim 1 , comprising 0.1 to 200 mg (kaempferol analog equivalent value) of the kaempferol analog or a glycoside thereof. 
     
     
         10 . The composition according to  claim 1 , comprising 0.5 mg to 100 mg (kaempferol analog equivalent value) of the kaempferol analog or a glycoside thereof. 
     
     
         11 . The composition according to  claim 1 , wherein said composition is for administration at a dose of 0.1 mg to 200 mg (kaempferol analog equivalent value) of the kaempferol analog or a glycoside thereof per administration. 
     
     
         12 . The composition according to  claim 1 , wherein said composition is for administration at a dose of 0.5 mg to 100 mg (kaempferol analog equivalent value) of the kaempferol analog or a glycoside thereof per administration. 
     
     
         13 . The composition according to  claim 1 , wherein said composition is for administration at a dose of 0.1 mg to 600 mg (kaempferol analog equivalent value) of the kaempferol analog or a glycoside thereof per day. 
     
     
         14 . The composition according to  claim 1 , wherein said composition is for administration at a dose of 0.5 mg to 200 mg (kaempferol analog equivalent value) of the kaempferol analog or a glycoside thereof per day. 
     
     
         15 . The composition of  claim 1 , wherein said composition is for administration to a subject who is hypoxic. 
     
     
         16 . The composition according to  claim 1 , wherein said composition is a food and drink. 
     
     
         17 . The composition according to  claim 1 , wherein said composition is a pharmaceutical composition.