Pain Medicine Combination and Uses Thereof

Abstract

Embodiments disclosed herein describe, amongst other things, dosage forms, compounds, compositions, pharmaceutical compositions that can be used in the treatment of, for example, pain and pain related disorders or to produce analgesia.

1 - 51 . (canceled) 
     
     
         52 . A dosage form formulated for simultaneous administration comprising active ingredients, wherein the active ingredients consist of:
 dextromethorphan, or a pharmaceutically acceptable salt thereof;   quinidine, or a pharmaceutically acceptable salt thereof, and   an opioid agonist, or a pharmaceutically acceptable salt thereof.   
     
     
         53 . The dosage form of  claim 52 , wherein the ratio of the opioid agonist, or a pharmaceutically acceptable salt thereof, to dextromethorphan, or a pharmaceutically acceptable salt thereof, to quinidine, or a pharmaceutically acceptable salt thereof, is about 1:1:1 (wt:wt:wt). 
     
     
         54 . The dosage form of  claim 52 , wherein the opioid agonist is morphine, or a pharmaceutically acceptable salt thereof, oxycodone, or a pharmaceutically acceptable salt thereof, or hydromorphone, or a pharmaceutically acceptable salt thereof. 
     
     
         55 . The dosage form of  claim 52 , wherein the opioid agonist is morphine, or a pharmaceutically acceptable salt thereof. 
     
     
         56 . The dosage form of  claim 52 , wherein the opioid agonist is oxycodone, or a pharmaceutically acceptable salt thereof. 
     
     
         57 . The dosage form of  claim 52 , wherein the opioid agonist is hydromorphone, or a pharmaceutically acceptable salt thereof. 
     
     
         58 . The dosage form of  claim 53 , wherein the opioid agonist is morphine, or a pharmaceutically acceptable salt thereof, oxycodone, or a pharmaceutically acceptable salt thereof, or hydromorphone, or a pharmaceutically acceptable salt thereof. 
     
     
         59 . The dosage form of  claim 53 , wherein the opioid agonist is morphine, or a pharmaceutically acceptable salt thereof. 
     
     
         60 . The dosage form of  claim 53 , wherein the opioid agonist is oxycodone, or a pharmaceutically acceptable salt thereof. 
     
     
         61 . The dosage form of  claim 53 , wherein the opioid agonist is hydromorphone, or a pharmaceutically acceptable salt thereof. 
     
     
         62 . The pharmaceutical composition of  claim 52 , wherein the dextromethorphan is dextromethorphan hydrobromide monohydrate. 
     
     
         63 . The pharmaceutical composition of  claim 52 , wherein the quinidine is quinidine gluconate or quinidine sulfate. 
     
     
         64 . The pharmaceutical composition of  claim 54 , wherein the morphine is morphine sulfate. 
     
     
         65 . The pharmaceutical composition of  claim 55 , wherein the morphine is morphine sulfate. 
     
     
         66 . The pharmaceutical composition of  claim 58 , wherein the morphine is morphine sulfate. 
     
     
         67 . The pharmaceutical composition of  claim 59 , wherein the morphine is morphine sulfate. 
     
     
         68 . The pharmaceutical composition of  claim 52 , wherein the composition does not have a sequestered opioid antagonist. 
     
     
         69 . A method of treating pain in a subject in need thereof, the method comprising administering to the subject the pharmaceutical composition of  claim 52 .