Aqueous composition based on polyoxymethylene dialkyl ethers (pom) and their use for the preservation and/or embalming of the human or animal body

Abstract

It also relates to a non-therapeutic method of preserving and/or embalming a dead human or animal body using the composition, such as the use of this composition for anatomopathological purposes.

1 . Aqueous composition wherein it comprises the following components:
 a) a mixture of polyoxymethylene dialkyl ethers (POM) selected from a mixture of compounds of the general formula R—(OCH 2 ) n —OR′,
 with R,R′ being identical or different and chosen from methyl and/or ethyl for at least 90%, preferably at least 95 mol %, of the total R+R′ and the rest of R,R′ being identical or different alkyls chosen from among those having 3 to 8 carbons and representing less than 10%, preferably less than 5 mol % of the total R+R′, and provided that: 
 a1) when R═R′=methyl, the mixture comprises the 3 compounds with n=3 to 5 or both compounds with n=3 to 4, and the weight of the compounds (with n=3 to 5 or n=3 to 4) represents at least 95%, preferably at least 99% of the total weight of the mixture and 
 a2) when R═R′=ethyl, the mixture comprises the 3 compounds with n=2 to 4 or both compounds with n=2 to 3 
 and the weight of the compounds (with n=2 to 4 or n=2 to 3) is at least 95%, preferably at least 99% of the total weight of the mixture 
 a3) when R=methyl and R′=ethyl, the mixture comprises the 4 compounds with n=2 to 5 or the 3 compounds with n=2 to 4 and the weight of the compounds (with n=2 to 5 or n=2 to 4) represents at least 95%, preferably at least 99% of the total weight of the mixture, 
   b) at least one biocidal agent   (c) at least one pro-penetrating agent   d) at least one dye,   e) optionally, at least one other additive   and water as diluent.   
     
     
         2 . Composition according to  claim 1 , wherein the proportion by weight of components a)+b)+c)+d)+e) represents from 0.5 to 30%, preferably from 1 to 25% and more. preferably from 1 to 20%, of the total weight of the aqueous composition. 
     
     
         3 . Composition according to  claim 1 , wherein the component a) represents from 20 to 50%, preferably from 30 to 40% by weight with respect to a)+b)+c)+d)+e), and from 0.5 to 15%, preferably from 0.8 to 8%, of the total weight of the aqueous composition. 
     
     
         4 . Composition according to  claim 1 , wherein the component a) is a mixture according to a1) with R═R′=methyl with n=3 to 5 or n=3 to 4. 
     
     
         5 . Composition according to  claim 1 , wherein the component a) is the mixture according to a2) with R═R=ethyl and with n=2 to 4 or with n=2 to 3. 
     
     
         6 . Composition according to  claim 1 , wherein the mixture is according to a3), with R=methyl and R′=ethyl and with n=2 to 5 or n=2 to 4. 
     
     
         7 . Composition according to  claim 1 , wherein the biocidal component b) is selected from: iodine, polyvinylpyrrolidone iodine (polyvinylpyrrolidone-iodine complex), bronopol or 2-bromo-2-nitro-1,3 propylene glycol, alkyl chloride (C12-C18) dimethylbenzylammonium (ADBAC C12-18), alkyl chloride (C12-C16) dimethylbenzylammonium (ADBAC/BKC C12-16), alkyl chloride (C12-C14) dimethylbenzylammonium (ADBAC C12-14); alkyl chloride (C12-C14) dimethyl ethyl benzyl ammonium (ADEBAC C12-14), glutaraldehyde; ethanol, peracetic acid, methyl ethyl ketone peroxide, butanedial, diethylacetal, glyoxal, diethylene glycol, organic acids such as ascorbic acid or citric acid, phenolics such as vanilic aldehyde, guaiacol, eugenol, phenol, methylparaben, propylparaben 1-hexadecylpyridinium chloride, a compound of the formula (C 3 H 4 O)n.(C 3 H 4 O 2 )m where n>m. 
     
     
         8 . Composition according to  claim 1 , wherein the biocidal component b) is chosen from: iodine, polyvinylpyrrolidone iodine (polyvinylpyrrolidone-iodine complex), bronopol, alkyl chloride (C12-C18) dimethylbenzylammonium (ADBAC C12-18), alkyl chloride (C12-C16) dimethyl benzyl ammonium (ADBAC/BKC C12-16), alkyl chloride (C12-C14) dimethyl benzyl ammonium chloride (ADBAC C12-14), alkyl chloride (C12-C14) dimethyl ethyl benzyl ammonium (ADEBAC C12-14), glutaraldehyde, a compound of formula (C 3 H 4 O)n.(CH 4 O 2 )m where n>m. 
     
     
         9 . Composition according to  claim 1 , wherein the pro-penetrating component c) is chosen from: propylene glycol, monoethylene glycol, glycerol, propanol-2, dimethyl sulfoxide, polyethylene glycol, 2-ethoxyethanol, 2 phenoxyethanol, tetrahydrofurfuryl alcohol, linear or branched C 2 -C 6  monoalcohol; a glycol such as 1,3-propanediol, 1,4-butanediol, 1,3-butanediol, 2,3-butanediol, hexylene glycol; a C 8 -C 22  fatty acid; a cyclodextrin; a surfactant; C 1 -C 4  alkyl acetate; a mono- or polyester of fatty acid and glycerol or propylene glycol; a fatty alcohol ester of lactic acid or glycolic acid; an ester of fatty acid and isopropyl; a C 8 -C1 8  fatty alcohol; an azone; an alkyl N,N-dialkylaminoalkanoate; an amide, urea; a urea derivative; a terpene; a terpenoid; methyl or benzyl nicotinate; a sulfoxide; isosorbide. 
     
     
         10 . Composition according to  claim 1 , wherein the pro-penetrating component c) is selected from propylene glycol, monoethylene glycol, glycerol, propanol-2, dimethylsulfoxide. 
     
     
         11 . Composition according to  claim 1 , wherein it comprises:
 0.5 to 10%, preferably 0.8 to 8% by weight of component a) relative to the total weight of the aqueous composition,   from 0.1 to 3%, preferably from 0.15 to 2% by weight of component b) relative to the total weight of the aqueous composition   from 0.5 to 10%, preferably from 0.8 to 8% by weight of component c) relative to the total weight of the aqueous composition   from 0.1 to 8%, preferably from 0.2 to 5% by weight of component d) relative to the total weight of the aqueous composition.   
     
     
         12 . Composition according to  claim 1 , wherein it comprises in addition to at least one other additive selected from: perfume as flower extracts such as rose (rose oil), lilac, or perfumes synthetic (aromatic esters with rather fresh notes like eucalyptus), borax, potassium nitrate, boric acid, sodium citrate, sodium hexametaphosphate, sodium acetate, hydrochloric acid, bis(tributyltin) oxide, sodium phosphate dibasic, sodium phosphate monobasic, ethylenediamine tetracetic acid (EDTA), sodium alkylsulfonate, potassium carbonate, trichloroacetaldehyde. 
     
     
         13 . Non-therapeutic method for preserving a human or animal body and/or embalming a dead body, the method comprising administering to the body a composition according to any  claim 1 . 
     
     
         14 . Method according to  claim 13 , wherein the composition is injected intra-arterially into the body. 
     
     
         15 . Method according to  claim 13 , wherein the composition is infused into the body. 
     
     
         16 . Method according to  claim 13 , wherein the composition is applied topically on the body. 
     
     
         17 . A method of preservation of organs, tissues or cells of a living or dead, human or animal organism/body, comprising the step of immersion of said organs, tissues or cells in the composition of  claim 1 . 
     
     
         18 . The method of  claim 17 , wherein said preservation is for anatomopathology purposes.