Composition, A Treatment Method and An Application Thereof

Abstract

The present invention relates to the field of treatment of tumor, and especially to a composition comprising a plasmodium, a treatment method and an application thereof. The composition of the present invention has therapeutic effects on colorectal carcinoma, lung carcinoma, breast carcinoma, gastric carcinoma and hepatic carcinoma etc., can inhibit the growth of tumor and prolong the life of the tumor patients, whereas has no therapeutic effect on melanoma and lymphoma; meanwhile, the present invention describes that the long-term plasmodium infection has better therapeutic effect on tumors, and the plasmodium immunotherapy of the present invention does not take the fever time as a course standard when treating tumors, but should be used to extend the duration of plasmodium infection as much as possible until the progression of tumors can be controlled under the premise of protecting the organ functions and life safety of the patients.

What is claimed is: 
     
         1 . A method for treating a solid tumor, comprising
 a) administering to a patient in need thereof a therapeutically effective amount of a composition comprising a plasmodium, wherein the plasmodium is any one or a mixture of at least two of  Plasmodium falciparum, Plasmodium vivax, Plasmodium malariae, Plasmodium ovale  or  Plasmodium knowlesi ; and   b) allowing a long-term plasmodium infection to establish in the patient, wherein the long-term plasmodium infection is a chronic malarial infection with an infection time course of more than 6-8 weeks,   wherein the solid tumor is selected from the group consisting of gastric carcinoma, colon carcinoma and breast carcinoma.   
     
     
         2 . The method according to  claim 1 , wherein the plasmodium is P vivax. 
     
     
         3 . The method according to  claim 1 , wherein the plasmodium is administrated at an amount of not less than 100 plasmodium infected red blood cells or not less than 5 plasmodium sporozoites. 
     
     
         4 . The method according to  claim 1 , wherein the method further comprises administering to the patient a pharmaceutically acceptable adjuvant. 
     
     
         5 . The method according to  claim 4 , wherein the adjuvant is any one or a combination of at least two of an excipient, a diluent, a carrier, a flavoring agent, a binder and a filler.