Compositions of citrulline

Abstract

The present disclosure relates generally to supplement compositions containing citrulline and taurine at a weight ratio of 4.56:1 to 2.57:1 which have been demonstrated to have a pleasant flavor and can enhance the exercise endurance in individuals in a synergistic manner.

1 . A solid composition comprising citrulline and taurine, wherein the citrulline and the taurine have a weight ratio of 5:1 to 1:5 and together constitute at least 55% w/w of the solid composition. 
     
     
         2 . The solid composition of  claim 1 , wherein the citrulline and the taurine have a weight ratio of 5:1 to 1:1. 
     
     
         3 . The solid composition of  claim 2 , which does not include more than 20% w/w of the combination of any other amino acid, vitamins, peptides, proteins, herb extracts, fatty acids, fibers, probiotics, glucosamine, chondroitin, and CoQ10. 
     
     
         4 . The solid composition of  claim 3 , wherein the citrulline and the taurine have a weight ratio of 4:1 to 2.85:1. 
     
     
         5 . The solid composition of  claim 3 , wherein the citrulline and the taurine have a weight ratio of 3.55:1 to 3:1. 
     
     
         6 . The solid composition of  claim 3 , wherein the citrulline and the taurine have a weight ratio of 3.35:1 to 3.08:1. 
     
     
         7 . The solid composition of  claim 3 , wherein the citrulline and the taurine together constitute at least 60% w/w of the solid composition. 
     
     
         8 . The solid composition of  claim 3 , wherein the citrulline and the taurine together constitute at least 75% w/w of the solid composition. 
     
     
         9 . The solid composition of  claim 1 , which is provided in the form of powders, tablets, granules, or capsules. 
     
     
         10 . The solid composition of  claim 9 , wherein the tablets or granules are effervescent tablets or granules. 
     
     
         11 . A drink comprising citrulline and taurine, wherein the citrulline and the taurine have a weight ratio of 5:1 to 1:5 and together constitute at least 55% w/w of total solid ingredients dissolved in the drink. 
     
     
         12 . The drink of  claim 11 , wherein the citrulline and the taurine have a weight ratio of 5:1 to 1:1. 
     
     
         13 . The drink of  claim 11 , wherein the citrulline and the taurine have a weight ratio of 4:1 to 2.85:1. 
     
     
         14 . The drink of  claim 11 , wherein the citrulline and the taurine have a weight ratio of 3.55:1 to 3:1. 
     
     
         15 . The drink of  claim 11 , wherein the citrulline and the taurine have a weight ratio of 3.35:1 to 3.08:1. 
     
     
         16 . The drink of  claim 12 , wherein the citrulline and the taurine together constitute at least 60% w/w of the total solid ingredients dissolved in the drink. 
     
     
         17 . The drink of  claim 12 , wherein the citrulline and the taurine together constitute at least 75% w/w of the total solid ingredients dissolved in the drink. 
     
     
         18 . A method for treating hypertension or prehypertension in a mammalian subject, comprising orally administering to the subject the drink of  claim 11 . 
     
     
         19 . The method of  claim 18 , wherein about 0.1 g to about 100 g of the combination of citrulline and the taurine are administered daily. 
     
     
         20 . The method of  claim 18 , wherein about 1 g to 10 g of the combination of citrulline and the taurine are administered daily.