Metal oxide and polymer controlled delivery systems, sunscreens, treatments and topical coating applicators

Abstract

Systems and methods for keeping various compounds stable in different ampoules in an applicator. Upon breaking open the ampoules, the compounds are mixed and applied. In one embodiment, the resulting mixture is a long lasting waterproof sunscreen for use on skin. In another embodiment, the resulting mixture applied one or more coatings to an article and may subsequently accomplish sustained release and/or transdermal delivery of a therapeutic.

What is claimed is: 
     
         1 . An applicator for coating an article comprising:
 a first container having a reservoir coating material to be supported directly on a surface of the article;   a second container having a diffusion barrier coating material to be applied on top of the reservoir coating material, the reservoir coating material containing a higher concentration of active ingredients and the diffusion barrier coating material containing a lower concentration of active ingredients to enable the diffusion barrier coating material to act as a rate controlling diffusion barrier;   a mixing tube, the first and second containers housed within the mixing tube; and   the applicator tip attached to the mixing tube.   
     
     
         2 . The applicator as recited in  claim 1 , wherein the diffusion barrier coating material becomes a dried diffusion barrier including a metal oxide after application. 
     
     
         3 . The applicator as recited in  claim 2 , wherein the metal oxide is a transition metal oxide. 
     
     
         4 . The applicator as recited in  claim 1 , wherein the reservoir coating material includes at least one active ingredient for delivery, the first container includes a solvent, and the second container contains a liquid. 
     
     
         5 . The applicator as recited in  claim 2 , wherein the metal oxide is selected from the group consisting of titanium oxides, vanadium oxides, zinc oxides, zirconium oxides, silver oxides, tantalum oxides, or combinations thereof. 
     
     
         6 . The applicator as recited in  claim 1 , wherein each of the first and second containers are ampoules. 
     
     
         7 . The applicator as recited in  claim 1 , wherein the article is human skin for transepithelial pharmacological delivery for delivery of a bioactive agent in the reservoir coating material. 
     
     
         8 . The applicator as recited in  claim 1 , wherein the second container includes an additive selected from a group consisting of:
 Aminobenzoic acid (PABA) up to 15 percent;   Avobenzone up to 3 percent;   Cinoxate up to 3 percent;   Dioxybenzone up to 3 percent;   Homosalate up to 15 percent;   Menthyl anthranilate up to 5 percent;   Octocrylene up to 10 percent;   Octyl methoxycinnamate up to 7.5 percent;   Octyl salicylate up to 5 percent;   Oxybenzone up to 6 percent;   Phenylbenzimidazole sulfonic acid up to 4 percent;   Sulisobenzone up to 10 percent;   Titanium dioxide up to 25 percent;   Trolamine salicylate up to 12 percent;   Zinc oxide up to 25 percent;   Ensulizole up to 4 percent;   Meradimate up to 5 percent;   Octinoxate up to 7.5 percent;   Octisalate up to 5 percent; and   Padimate O up to 8 percent.   
     
     
         9 . The applicator as recited in  claim 1 , wherein the second container contains 95% titanium isopropoxide and 5% meth-oxy functionalized polydimethylsiloxane, which is diluted to about a 1.25% solution with alcohol or a mixture of alcohol and non-polar solvent. 
     
     
         10 . An applicator for coating for an article comprising:
 a first ampoule having a reservoir coating to be supported directly on a surface of the article;   a second ampoule having a diffusion barrier coating to be applied on top of the reservoir coating, the diffusion barrier coating including a metal oxide, the reservoir coating containing a higher concentration of active ingredients and the diffusion barrier coating containing a lower concentration of active ingredients to enable the diffusion barrier coating to act as a rate controlling diffusion barrier; a mixing tube, the first and second ampoules housed within the mixing tube; and   the applicator tip attached to the mixing tube.   
     
     
         11 . The applicator as recited in  claim 10 , wherein the first ampoule includes a solvent. 
     
     
         12 . The applicator as recited in  claim 10 , wherein the reservoir coating including at least one active ingredient for delivery. 
     
     
         13 . The applicator as recited in  claim 10 , wherein the first and second ampoules are in a form of first and second distinct containers. 
     
     
         14 . The applicator as recited in  claim 13 , wherein the first and second distinct containers are first and second tubes. 
     
     
         15 . An applicator for coating for an article comprising:
 a first container having a reservoir coating material to be supported directly on a surface of the article; and   a second container having a diffusion barrier coating material to be applied on top of the reservoir coating material, the diffusion barrier coating including a polymer.   
     
     
         16 . The applicator as recited in  claim 15  wherein the diffusion barrier coating material becomes a dried diffusion barrier including a metal oxide after application. 
     
     
         17 . The applicator as recited in  claim 16  wherein the metal oxide is a transition metal oxide and the polymer is functionalized. 
     
     
         18 . The applicator as recited in  claim 16  wherein the reservoir coating material includes at least one active ingredient for delivery, the first container includes a solvent, and the containers contain a liquid. 
     
     
         19 . The applicator as recited in  claim 16  wherein the metal oxide is selected from the group consisting of titanium oxides, vanadium oxides, zinc oxides, zirconium oxides, silver oxides, tantalum oxides, or combinations thereof. 
     
     
         20 . The applicator as recited in  claim 1 , wherein the second container includes at least one active ingredient selected from the group consisting of an antimicrobial, antibiotic, antifungal, and a sun screen ingredient.