Nasal administration

Abstract

A delivery device for and method of providing for delivery of substance to the central nervous system (CNS) of a subject, the delivery device comprising: a nosepiece unit (17) for insertion into a nasal airway (1) of a subject and comprising an outlet unit (21) which includes a nozzle (25) for delivering substance into the nasal airway of the subject; and a substance supply unit which is operable to deliver a dose of substance to the nozzle: wherein the delivery device is configured such that at least 30% of the dose as initially deposited in the nasal airway is deposited in an upper posterior region of the nasal airway, thereby providing a CNS concentration of the substance, and hence CNS effect, which is significantly greater than that which would be predicted from a counterpart blood plasma concentration of the substance.

1 - 85 . (canceled) 
     
     
         86 . A liquid substance delivery device, comprising:
 a housing;   a nosepiece attached to the housing via a snap-fit connection, the nosepiece including an outlet and a cuff member, the cuff member configured to block a nasal valve of a subject when at least a portion of the nosepiece is fitted in a nasal passage of the subject;   a mouthpiece attached to the housing and comprising an inlet, the inlet of the mouthpiece being fluidly connected via the housing to the outlet of the nosepiece;   a liquid delivery pump configured to expel a metered amount of pharmaceutical substance through the outlet of the nosepiece upon actuation of the pump;   a gas supply unit configured to deliver an amount of gas through the outlet of the nosepiece, the delivered gas being a pharmaceutically acceptable gas other than an exhaled air flow;   wherein the liquid delivery pump contains a plurality of metered amounts of the pharmaceutical substance.