Hydrophobic highly branched carbohydrate polymers

Abstract

A material comprising a highly branched carbohydrate polymer, a polyalkylene glycol (or polyalkylene oxide) linked to the highly branched carbohydrate polymer, and a hydrophobic or amphiphilic group linked to the highly branched carbohydrate polymer and/or the polyalkylene glycol (or polyalkylene oxide), is described. Methods of making and using the material, as well as a soluble composition that contains the material and a hydrophobic solute compound, are also described.

1 . A material comprising:
 a highly branched carbohydrate polymer;   a polyalkylene glycol, linked to the highly branched carbohydrate polymer; and   a hydrophobic or amphiphilic group linked to the highly branched carbohydrate polymer and/or the polyalkylene glycol.   
     
     
         2 . The material of  claim 1 , wherein the material is a solubilizing agent. 
     
     
         3 . The material of  claim 1 , wherein the hydrophobic or amphiphilic group is linked to polyalkylene glycol. 
     
     
         4 . The material of  claim 1 , wherein the highly branched carbohydrate polymer has a dendritic or dendrimer-like structure. 
     
     
         5 . The material of  claim 1 , wherein the highly branched carbohydrate polymer is a highly branched alpha-D-glucan. 
     
     
         6 . The material of  claim 1 , wherein the highly branched carbohydrate polymer is glycogen, phytoglycogen, or a modified form thereof. 
     
     
         7 . The material of  claim 1 , wherein the polyalkylene glycol is polyethylene glycol or polypropylene glycol. 
     
     
         8 . The material of  claim 1 , wherein the hydrophobic or amphiphilic group is selected from the group consisting of acetate group, propionate group, butyrate group, octenyl succinate group, and combinations thereof. 
     
     
         9 . The material of  claim 1  is octenylsuccinate hydroxypropyl phytoglycogen (OHPP). 
     
     
         10 . A composition comprising:
 niclosamide; and   the material of  claim 1 .   
     
     
         11 . A pharmaceutical formulation comprising the composition of  claim 10 , and with or without other pharmaceutically acceptable component. 
     
     
         12 . The pharmaceutical formulation of  claim 11  in which the formulation is in dosage form. 
     
     
         13 . A method of making a composition of  claim 10  comprising:
 combining niclosamide with the material of  claim 1 , with or without other pharmaceutically acceptable material. 
 
     
     
         14 . The method of  claim 13  in which the niclosamide is combined with the material of  claim 1 , with or without other pharmaceutically acceptable material, using a method selected from the group consisting of extrusion, mixing, spray drying, vacuum drying, kneading, rolling, ultra-sonication, vibration, milling, and combinations thereof. 
     
     
         15 . A composition comprising:
 niclosamide; and   octenylsuccinate hydroxypropyl phytoglycogen (OHPP).   
     
     
         16 . A pharmaceutical formulation comprising the composition of  claim 15 , and with or without other a pharmaceutically acceptable component. 
     
     
         17 . The pharmaceutical formulation of  claim 16  in which the formulation is in dosage form. 
     
     
         18 . A method of making a composition of  claim 15  comprising:
 combining niclosamide with OHPP, with or without other pharmaceutically acceptable material. 
 
     
     
         19 . The method of  claim 18  in which the niclosamide is combined with OHPP, with or without another pharmaceutically acceptable material, using a method selected from the group consisting of extrusion, mixing, spray drying, vacuum drying, kneading, rolling, ultra-sonication, vibration, milling, and combinations thereof. 
     
     
         20 . A method for administering niclosamide to a subject comprising:
 administering to the subject a pharmaceutical formulation or dosage form of  claim 11  using pharmaceutical acceptable routes.   
     
     
         21 . A method for administering niclosamide to a subject comprising:
 administering to the subject a pharmaceutical formulation or dosage form of  claim 16  using pharmaceutical acceptable routes.